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Regulatory B Cells

  • Reference work entry
  • First Online:
Encyclopedia of Medical Immunology

  • 523 Accesses

Synonyms

B10 B cells; Bregs; Killer B cells; Suppressor B cells; T2-like Bregs

Definition

Regulatory B cells are CD19+ lymphocytes that can inhibit inflammation in vivo or suppress the activation of immune cells in vitro or in vivo.

Introduction

The primary function of B cells is to participate in adaptive immune responses, acting as the precursor cells for immunoglobulin-producing plasma cells, presenting antigen to T cells and iNKT cells, and producing Th1 and Th2 cytokines that support the activation and differentiation of other lymphocytes. In certain circumstances, a particular subset, or subsets, of B cells, or a temporally/experimentally induced functional group of B cells, can play a role in controlling inflammation both in vivo and in vitro. These B cells have been named regulatory B cells (Bregs) (DiLillo et al. 2010; Mauri and Bosma 2012).

B cells with a regulatory function have been identified in a number of mouse models, primarily of autoimmunity but also infection,...

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Author information

Authors and Affiliations

  1. Division of Medicine, University College London, London, UK

    Claudia Mauri

  2. Division of Medicine, Centre for Rheumatology Research, University College London, London, UK

    Paul Blair

Authors
  1. Claudia Mauri
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  2. Paul Blair
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Corresponding author

Correspondence to Claudia Mauri .

Editor information

Editors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia

    Ian R. Mackay

  2. Center for Autoimmune Disease Research, Department of Molecular Microbiology and Immunology, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA

    Noel R. Rose

  3. The Feinstein Institute for Medical Research, Manhasset, NY, USA

    Betty Diamond

  4. The Feinstein Institute for Medical Research, Manhasset, NY, USA

    Anne Davidson

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Mauri, C., Blair, P. (2014). Regulatory B Cells. In: Mackay, I.R., Rose, N.R., Diamond, B., Davidson, A. (eds) Encyclopedia of Medical Immunology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-84828-0_551

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  • DOI: https://doi.org/10.1007/978-0-387-84828-0_551

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-84827-3

  • Online ISBN: 978-0-387-84828-0

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