Definition
A systemic inflammatory disease characterized by necrotizing medium-vessel vasculitis.
History
Polyarteritis nodosa (PAN) was the first vasculitis to be described in the medical literature (Kussmaul and Maier 1866). While the initial descriptions of this illness included clinical manifestations and consequences of necrotizing small- and medium-vessel inflammation, microscopic polyangiitis was described as an independent disease in 1949, and the Chapel Hill Consensus Conference defined PAN strictly as a medium-vessel vasculitis (Jennette et al. 1994).
Epidemiology
The annual incidence of PAN has been reported to be 9.0 per million in Olmsted County, Minnesota (Kurland et al. 1984). Overall, PAN is a rare illness when carefully defined, and successful immunization against hepatitis B has led to a decline in cases associated with this infection. It tends to affect both genders equally and can involve patients of all ages.
Etiology
The etiology of PAN is unknown. It may occur as...
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References
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Khasnis, A., Calabrese, L.H. (2014). Polyarteritis Nodosa. In: Mackay, I.R., Rose, N.R., Diamond, B., Davidson, A. (eds) Encyclopedia of Medical Immunology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-84828-0_484
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DOI: https://doi.org/10.1007/978-0-387-84828-0_484
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