Synonyms
Lymphoid phosphatase, LYP; Lymphoid-specific protein tyrosine phosphatase; PEST-domain phosphatase; PEST-enriched phosphatase, Pep; Protein tyrosine phosphatase, non-receptor type 8; Tyrosine-protein phosphatase non-receptor type 22
Definition
PTPN22 – a gene encoding the lymphoid phosphatase, a classical non-receptor protein tyrosine phosphatase expressed in hematopoietic cells.
Discovery of PTPN22
The human PTPN22 gene is located on chromosome 1p13.3–13.1 and encodes the lymphoid phosphatase (LYP), a protein tyrosine phosphatase (PTP) cloned in 1999 by Chaim Roifman’s laboratory (Stanford et al. 2010; Veillette et al. 2009). LYP shares 70 % sequence identity with the orthologous murine phosphatase Pep (PEST-enriched phosphatase), which had been cloned in 1992 by Matthew Thomas’ laboratory and originally identified under the gene name Ptpn8. LYP/Pep belong to the PEST-enriched subfamily of non-receptor classical PTPs, which includes PTP-PEST (encoded by the PTPN12gene) and...
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Stanford, S.M., Bottini, M., Bottini, N. (2014). PTPN22. In: Mackay, I.R., Rose, N.R., Diamond, B., Davidson, A. (eds) Encyclopedia of Medical Immunology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-84828-0_46
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