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Juvenile Diseases: SLE in Children

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Encyclopedia of Medical Immunology

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Synonyms

Juvenile-onset SLE; Pediatric SLE

Definition

Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder that can affect any organ of the human body. Presentation and clinical courses are highly variable which is why 11 diagnostic criteria were introduced and 4 must be fulfilled to make a diagnosis of SLE (Tsokos 2011; Hochberg 1997).

The pathophysiology of SLE is not completely understood; genetic, hormonal, and environmental factors, all contribute to the development of the disease (Hedrich et al. 2011). Women are affected more frequently with an overall female to male ratio of 10:1 (Tsokos 2011). Approximately 10–20 % of all SLE manifestations occur in the pediatric age group (before 16 years of age) and are classified as pediatric SLE (or juvenile-onset SLE) (Ardoin and Schanberg 2012; Brunner et al. 2011). Cases with a disease onset before 5 years of age, referred to as early-onset SLE, are extremely uncommon and appear to be more severe when compared to other...

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Author information

Authors and Affiliations

  1. Department of Medicine, Division of Rheumatology, Beth Israel Deaconess Medical Center, Boston, MA, USA

    Christian Michael Hedrich

  2. Children’s Hospital Dresden, Pediatric Rheumatology and Immunology Section, University Medical Center “Carl Gustav Carus” Technical University Dresden, Fetscherstr. 74, 01307, Dresden, Germany

    Christian Michael Hedrich

Authors
  1. Christian Michael Hedrich
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Corresponding author

Correspondence to Christian Michael Hedrich .

Editor information

Editors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia

    Ian R. Mackay

  2. Center for Autoimmune Disease Research, Department of Molecular Microbiology and Immunology, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA

    Noel R. Rose

  3. The Feinstein Institute for Medical Research, Manhasset, NY, USA

    Betty Diamond

  4. The Feinstein Institute for Medical Research, Manhasset, NY, USA

    Anne Davidson

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Hedrich, C.M. (2014). Juvenile Diseases: SLE in Children. In: Mackay, I.R., Rose, N.R., Diamond, B., Davidson, A. (eds) Encyclopedia of Medical Immunology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-84828-0_395

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  • DOI: https://doi.org/10.1007/978-0-387-84828-0_395

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-84827-3

  • Online ISBN: 978-0-387-84828-0

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