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Discoid SLE

  • Reference work entry
  • First Online:
Encyclopedia of Medical Immunology

  • 471 Accesses

Synonyms

Chronic cutaneous lupus erythematosus; Discoid lupus erythematosus; Lupus erythematosus chronicus discoides

Definition

Discoid lupus erythematosus (DLE) is a chronic, autoimmune, inflammatory disease of the skin characterized by coin-shaped (discoid) lesions that give rise to scarring, atrophy, alopecia, and pigment changes as they heal. These lesions often occur on sun-exposed areas such as the face, ears, and hands although any cutaneous region as well as some mucosa can be affected.

Classification

The disease can present as localized, generalized, or childhood DLE (William et al. 2011)

  1. 1.

    Localized DLE: Lesions are found above the neck, with favored sites including the malar areas, bridge of nose, scalp (leading to alopecia), ears, and lower lip. This form of DLE may rarely involve the mucosa of the mouth, nose, eye, or vulva.

  2. 2.

    Generalized DLE: Less common than the localized form, generalized DLE often affects the thorax and upper extremities in addition to the head and...

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Authors and Affiliations

  1. Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, #139 Renmin Middle Road, The 2nd Xiangya Hospital, Changsha, Hunan, 410011, People’s Republic of China

    Qianjin Lu

Authors
  1. Qianjin Lu
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Correspondence to Qianjin Lu .

Editor information

Editors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia

    Ian R. Mackay

  2. Center for Autoimmune Disease Research, Department of Molecular Microbiology and Immunology, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA

    Noel R. Rose

  3. The Feinstein Institute for Medical Research, Manhasset, NY, USA

    Betty Diamond

  4. The Feinstein Institute for Medical Research, Manhasset, NY, USA

    Anne Davidson

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Lu, Q. (2014). Discoid SLE. In: Mackay, I.R., Rose, N.R., Diamond, B., Davidson, A. (eds) Encyclopedia of Medical Immunology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-84828-0_379

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  • DOI: https://doi.org/10.1007/978-0-387-84828-0_379

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-84827-3

  • Online ISBN: 978-0-387-84828-0

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