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CD40

  • Reference work entry
  • First Online:
Encyclopedia of Medical Immunology

  • 499 Accesses

Synonyms

BP50; CDW40; P50; TNFR superfamily member 5 (TNFR5)

Definition

Historical Background

CD40 is a type I integral membrane protein and a member of the tumor necrosis factor receptor (TNFR) family of molecules that functions as a major communication link between antigen-presenting cells (APCs) (B cells, macrophage, and dendritic cells (DCs)) and CD4 T cells. In the years prior to the discovery of CD40, there was widespread appreciation that antigen-specific activation of naïve B cells required contact-dependent interactions with activated T cells. However, only subsequent to demonstrating that contact was independent of cognate MHC interactions did it become clear that B-T cell contact required interactions with membrane-associated factors and not just cytokines (Banchereau et al. 1994; Lederman et al. 1993). CD40 was initially discovered as a B cell surface protein that could drive the proliferation and enhance the differentiation of B cells following stimulation with anti-CD40...

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References

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Author information

Authors and Affiliations

  1. Department of Cell Biology and Neuroscience, Rutgers University, The State University of New Jersey, 604 Allison Road, Piscataway, NJ, 08854, USA

    Lori R. Covey

Authors
  1. Lori R. Covey
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Corresponding author

Correspondence to Lori R. Covey .

Editor information

Editors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia

    Ian R. Mackay

  2. Center for Autoimmune Disease Research, Department of Molecular Microbiology and Immunology, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA

    Noel R. Rose

  3. The Feinstein Institute for Medical Research, Manhasset, NY, USA

    Betty Diamond

  4. The Feinstein Institute for Medical Research, Manhasset, NY, USA

    Anne Davidson

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© 2014 Springer Science+Business Media New York

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Covey, L.R. (2014). CD40. In: Mackay, I.R., Rose, N.R., Diamond, B., Davidson, A. (eds) Encyclopedia of Medical Immunology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-84828-0_32

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  • DOI: https://doi.org/10.1007/978-0-387-84828-0_32

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-84827-3

  • Online ISBN: 978-0-387-84828-0

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