Skip to main content
SpringerLink
Log in

Bcl-2 Family Members and Lymphocyte Homeostasis

  • Reference work entry
  • First Online:
Encyclopedia of Medical Immunology

  • 419 Accesses

Synonyms

A1, Bcl-2-related protein A1, BCL2L5, BFL1; Bad, BCL2-associated agonist of cell death, BBC2, BCL2L8; Bak, BCL2-antagonist/killer, BCL2L7; Bax, BCL2-associated X protein, BCL2L4; Bcl-2, B cell lymphoma 2, PPP1R50; Bcl-xL, BCL2L1, Bcl-X, PPP1R52; Bid, BH3 interacting domain death agonist; Bik, BCL2-interacting killer; Bim, BCL2L11; Bok, BCL2-related ovarian killer, BCL2L9, BOKL; Hrk, harakiri Bcl-2 interacting protein; Mcl-1, myeloid cell leukemia sequence 1, BCL2L3; Noxa; Puma

Definition

Regulating T and B cell development and peripheral homeostasis is critical to prevent aberrant immune responses. Apoptosis is a form of programmed cell death crucial for maintaining homeostasis of T and B cells. During T and B cell development, apoptosis is involved in eliminating self-reactive cells, which is necessary to prevent autoimmunity. In the case of an infection, activated T and B cells undergo expansion in response to antigen stimulation and subsequently develop effector functions....

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 799.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 949.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Akashi K, Kondo M, von Freeden-Jeffry U, Murray R, Weissman IL. Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Cell. 1997;89:1033–41.

    CAS  PubMed  Google Scholar 

  • Batten M, Groom J, Cachero TG, Qian F, Schneider P, Tschopp J, Browning JL, Mackay F. BAFF mediates survival of peripheral immature B lymphocytes. J Exp Med. 2000;192:1453–66.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Berard M, Brandt K, Bulfone-Paus S, Tough DF. IL-15 promotes the survival of naive and memory phenotype CD8+ T cells. J Immunol. 2003;170:5018–26.

    CAS  PubMed  Google Scholar 

  • Blattman JN, Grayson JM, Wherry EJ, Kaech SM, Smith KA, Ahmed R. Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo. Nat Med. 2003;9:540–7.

    CAS  PubMed  Google Scholar 

  • Bouillet P, Metcalf D, Huang DC, Tarlinton DM, Kay TW, Kontgen F, Adams JM, Strasser A. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science. 1999;286:1735–8.

    CAS  PubMed  Google Scholar 

  • Bouillet P, Cory S, Zhang LC, Strasser A, Adams JM. Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim. Dev Cell. 2001;1:645–53.

    CAS  PubMed  Google Scholar 

  • Bouillet P, Purton JF, Godfrey DI, Zhang LC, Coultas L, Puthalakath H, Pellegrini M, Cory S, Adams JM, Strasser A. BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature. 2002;415:922–6.

    CAS  PubMed  Google Scholar 

  • Brunner T, Mogil RJ, LaFace D, Yoo NJ, Mahboubi A, Echeverri F, Martin SJ, Force WR, Lynch DH, Ware CF, et al. Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas. Nature. 1995;373:441–4.

    CAS  PubMed  Google Scholar 

  • Carrington EM, Vikstrom IB, Light A, Sutherland RM, Londrigan SL, Mason KD, Huang DC, Lew AM, Tarlinton DM. BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs. Proc Natl Acad Sci USA. 2010;107:10967–71.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Chao DT, Korsmeyer SJ. BCL-XL-regulated apoptosis in T cell development. Int Immunol. 1997;9:1375–84.

    CAS  PubMed  Google Scholar 

  • Corcoran AE, Riddell A, Krooshoop D, Venkitaraman AR. Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor. Nature. 1998;391:904–7.

    CAS  PubMed  Google Scholar 

  • Craxton A, Draves KE, Gruppi A, Clark EA. BAFF regulates B cell survival by downregulating the BH3-only family member Bim via the ERK pathway. J Exp Med. 2005;202:1363–74.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Dhein J, Walczak H, Baumler C, Debatin KM, Krammer PH. Autocrine T-cell suicide mediated by APO-1/(Fas/CD95). Nature. 1995;373:438–41.

    CAS  PubMed  Google Scholar 

  • Dias S, Silva Jr H, Cumano A, Vieira P. Interleukin-7 is necessary to maintain the B cell potential in common lymphoid progenitors. J Exp Med. 2005;201:971–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Dunkle A, Dzhagalov I, He YW. Mcl-1 promotes survival of thymocytes by inhibition of Bak in a pathway separate from Bcl-2. Cell Death Differ. 2010;17:994–1002.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Dzhagalov I, Dunkle A, He YW. The anti-apoptotic Bcl-2 family member Mcl-1 promotes T lymphocyte survival at multiple stages. J Immunol. 2008;181:521–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Ekland EH, Forster R, Lipp M, Cyster JG. Requirements for follicular exclusion and competitive elimination of autoantigen-binding B cells. J Immunol. 2004;172:4700–8.

    CAS  PubMed  Google Scholar 

  • Enders A, Bouillet P, Puthalakath H, Xu Y, Tarlinton DM, Strasser A. Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells. J Exp Med. 2003;198:1119–26.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Erlacher M, Labi V, Manzl C, Bock G, Tzankov A, Hacker G, Michalak E, Strasser A, Villunger A. Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction. J Exp Med. 2006;203:2939–51.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Fang W, Mueller DL, Pennell CA, Rivard JJ, Li YS, Hardy RR, Schlissel MS, Behrens TW. Frequent aberrant immunoglobulin gene rearrangements in pro-B cells revealed by a bcl-xL transgene. Immunity. 1996;4:291–9.

    CAS  PubMed  Google Scholar 

  • Fischer SF, Belz GT, Strasser A. BH3-only protein Puma contributes to death of antigen-specific T cells during shutdown of an immune response to acute viral infection. Proc Natl Acad Sci USA. 2008;105:3035–40.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Goodyear CS, Corr M, Sugiyama F, Boyle DL, Silverman GJ. Cutting edge: Bim is required for superantigen-mediated B cell death. J Immunol. 2007;178:2636–40.

    CAS  PubMed  Google Scholar 

  • Grillot DA, Merino R, Nunez G. Bcl-XL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice. J Exp Med. 1995;182:1973–83.

    CAS  PubMed  Google Scholar 

  • Hao Z, Duncan GS, Seagal J, Su YW, Hong C, Haight J, Chen NJ, Elia A, Wakeham A, Li WY, Liepa J, Wood GA, Casola S, Rajewsky K, Mak TW. Fas receptor expression in germinal-center B cells is essential for T and B lymphocyte homeostasis. Immunity. 2008;29:615–27.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Harada H, Quearry B, Ruiz-Vela A, Korsmeyer SJ. Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity. Proc Natl Acad Sci USA. 2004;101:15313–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Hartley SB, Cooke MP, Fulcher DA, Harris AW, Cory S, Basten A, Goodnow CC. Elimination of self-reactive B lymphocytes proceeds in two stages: arrested development and cell death. Cell. 1993;72:325–35.

    CAS  PubMed  Google Scholar 

  • Hatada EN, Do RK, Orlofsky A, Liou HC, Prystowsky M, MacLennan IC, Caamano J, Chen-Kiang S. NF-kappa B1 p50 is required for BLyS attenuation of apoptosis but dispensable for processing of NF-kappa B2 p100 to p52 in quiescent mature B cells. J Immunol. 2003;171:761–8.

    CAS  PubMed  Google Scholar 

  • Hildeman DA, Zhu Y, Mitchell TC, Bouillet P, Strasser A, Kappler J, Marrack P. Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim. Immunity. 2002;16:759–67.

    CAS  PubMed  Google Scholar 

  • Hildeman D, Jorgensen T, Kappler J, Marrack P. Apoptosis and the homeostatic control of immune responses. Curr Opin Immunol. 2007;19:516–21.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Hsu BL, Harless SM, Lindsley RC, Hilbert DM, Cancro MP. Cutting edge: BLyS enables survival of transitional and mature B cells through distinct mediators. J Immunol. 2002;168:5993–6.

    CAS  PubMed  Google Scholar 

  • Hughes PD, Belz GT, Fortner KA, Budd RC, Strasser A, Bouillet P. Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity. Immunity. 2008;28:197–205.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Huntington ND, Labi V, Cumano A, Vieira P, Strasser A, Villunger A, Di Santo JP, Alves NL. Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim sustains B lymphopoiesis in the absence of IL-7. Int Immunol. 2009;21:715–25.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Hutcheson J, Scatizzi JC, Bickel E, Brown NJ, Bouillet P, Strasser A, Perlman H. Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis. J Exp Med. 2005;201:1949–60.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Hutcheson J, Scatizzi JC, Siddiqui AM, Haines 3rd GK, Wu T, Li QZ, Davis LS, Mohan C, Perlman H. Combined deficiency of proapoptotic regulators Bim and Fas results in the early onset of systemic autoimmunity. Immunity. 2008;28:206–17.

    CAS  PubMed  Google Scholar 

  • Jorgensen TN, McKee A, Wang M, Kushnir E, White J, Refaeli Y, Kappler JW, Marrack P. Bim and Bcl-2 mutually affect the expression of the other in T cells. J Immunol. 2007;179:3417–24.

    CAS  PubMed  Google Scholar 

  • Kawabe Y, Ochi A. Programmed cell death and extrathymic reduction of Vbeta8+ CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin B. Nature. 1991;349:245–8.

    CAS  PubMed  Google Scholar 

  • Khaled AR, Kim K, Hofmeister R, Muegge K, Durum SK. Withdrawal of IL-7 induces Bax translocation from cytosol to mitochondria through a rise in intracellular pH. Proc Natl Acad Sci USA. 1999;96:14476–81.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Khaled AR, Li WQ, Huang J, Fry TJ, Khaled AS, Mackall CL, Muegge K, Young HA, Durum SK. Bax deficiency partially corrects interleukin-7 receptor alpha deficiency. Immunity. 2002;17:561–73.

    CAS  PubMed  Google Scholar 

  • Kim K, Lee CK, Sayers TJ, Muegge K, Durum SK. The trophic action of IL-7 on pro-T cells: inhibition of apoptosis of pro-T1, -T2, and -T3 cells correlates with Bcl-2 and Bax levels and is independent of Fas and p53 pathways. J Immunol. 1998;160:5735–41.

    CAS  PubMed  Google Scholar 

  • Kondrack RM, Harbertson J, Tan JT, McBreen ME, Surh CD, Bradley LM. Interleukin 7 regulates the survival and generation of memory CD4 cells. J Exp Med. 2003;198:1797–806.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Kurtulus S, Tripathi P, Opferman JT, Hildeman DA. Contracting the ‘mus cells’–does down-sizing suit us for diving into the memory pool? Immunol Rev. 2010;236:54–67.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Kurtulus S, Tripathi P, Moreno-Fernandez ME, Sholl A, Katz JD, Grimes HL, Hildeman DA. Bcl-2 allows effector and memory CD8+ T cells to tolerate higher expression of Bim. J Immunol. 2011;186:5729–37.

    CAS  PubMed  Google Scholar 

  • Lenschow DJ, Sperling AI, Cooke MP, Freeman G, Rhee L, Decker DC, Gray G, Nadler LM, Goodnow CC, Bluestone JA. Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen. J Immunol. 1994;153:1990–7.

    CAS  PubMed  Google Scholar 

  • Li WQ, Jiang Q, Khaled AR, Keller JR, Durum SK. Interleukin-7 inactivates the pro-apoptotic protein Bad promoting T cell survival. J Biol Chem. 2004;279:29160–6.

    CAS  PubMed  Google Scholar 

  • Lindsten T, Ross AJ, King A, Zong WX, Rathmell JC, Shiels HA, Ulrich E, Waymire KG, Mahar P, Frauwirth K, Chen Y, Wei M, Eng VM, Adelman DM, Simon MC, Ma A, Golden JA, Evan G, Korsmeyer SJ, MacGregor GR, Thompson CB. The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell. 2000;6:1389–99.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Liston A, Lesage S, Gray DH, O'Reilly LA, Strasser A, Fahrer AM, Boyd RL, Wilson J, Baxter AG, Gallo EM, Crabtree GR, Peng K, Wilson SR, Goodnow CC. Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim. Immunity. 2004;21:817–30.

    CAS  PubMed  Google Scholar 

  • Liu X, Zhu Y, Dai S, White J, Peyerl F, Kappler JW, Marrack P. Bcl-xl does not have to bind Bax to protect T cells from death. J Exp Med. 2006;203:2953–61.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Ma A, Pena JC, Chang B, Margosian E, Davidson L, Alt FW, Thompson CB. Bclx regulates the survival of double-positive thymocytes. Proc Natl Acad Sci USA. 1995;92:4763–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Mackay F, Browning JL. BAFF: a fundamental survival factor for B cells. Nat Rev Immunol. 2002;2:465–75.

    CAS  PubMed  Google Scholar 

  • Mandal M, Borowski C, Palomero T, Ferrando AA, Oberdoerffer P, Meng F, Ruiz-Vela A, Ciofani M, Zuniga-Pflucker JC, Screpanti I, Look AT, Korsmeyer SJ, Rajewsky K, von Boehmer H, Aifantis I. The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J Exp Med. 2005;201:603–14.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Maraskovsky E, O'Reilly LA, Teepe M, Corcoran LM, Peschon JJ, Strasser A. Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1−/− mice. Cell. 1997;89:1011–9.

    CAS  PubMed  Google Scholar 

  • Maraskovsky E, Peschon JJ, McKenna H, Teepe M, Strasser A. Overexpression of Bcl-2 does not rescue impaired B lymphopoiesis in IL-7 receptor-deficient mice but can enhance survival of mature B cells. Int Immunol. 1998;10:1367–75.

    CAS  PubMed  Google Scholar 

  • Marsden VS, Strasser A. Control of apoptosis in the immune system: Bcl-2, BH3-only proteins and more. Annu Rev Immunol. 2003;21:71–105.

    CAS  PubMed  Google Scholar 

  • Merino D, Giam M, Hughes PD, Siggs OM, Heger K, O'Reilly LA, Adams JM, Strasser A, Lee EF, Fairlie WD, Bouillet P. The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins. J Cell Biol. 2009;186:355–62.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Miller JP, Izon D, DeMuth W, Gerstein R, Bhandoola A, Allman D. The earliest step in B lineage differentiation from common lymphoid progenitors is critically dependent upon interleukin 7. J Exp Med. 2002;196:705–11.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Motoyama N, Wang F, Roth KA, Sawa H, Nakayama K, Negishi I, Senju S, Zhang Q, Fujii S, et al. Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice. Science. 1995;267:1506–10.

    CAS  PubMed  Google Scholar 

  • Obar JJ, Molloy MJ, Jellison ER, Stoklasek TA, Zhang W, Usherwood EJ, Lefrancois L. CD4+ T cell regulation of CD25 expression controls development of short-lived effector CD8+ T cells in primary and secondary responses. Proc Natl Acad Sci USA. 2010;107:193–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Oliver PM, Wang M, Zhu Y, White J, Kappler J, Marrack P. Loss of Bim allows precursor B cell survival but not precursor B cell differentiation in the absence of interleukin 7. J Exp Med. 2004;200:1179–87.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Oliver PM, Vass T, Kappler J, Marrack P. Loss of the proapoptotic protein, Bim, breaks B cell anergy. J Exp Med. 2006;203:731–41.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Opferman JT. Apoptosis in the development of the immune system. Cell Death Differ. 2008;15:234–42.

    CAS  PubMed  Google Scholar 

  • Opferman JT, Letai A, Beard C, Sorcinelli MD, Ong CC, Korsmeyer SJ. Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature. 2003;426:671–6.

    CAS  PubMed  Google Scholar 

  • Osborne LC, Dhanji S, Snow JW, Priatel JJ, Ma MC, Miners MJ, Teh HS, Goldsmith MA, Abraham N. Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7R alpha mutant mice. J Exp Med. 2007;204:619–31.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Pellegrini M, Bouillet P, Robati M, Belz GT, Davey GM, Strasser A. Loss of Bim increases T cell production and function in interleukin 7 receptor-deficient mice. J Exp Med. 2004;200:1189–95.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Peschon JJ, Morrissey PJ, Grabstein KH, Ramsdell FJ, Maraskovsky E, Gliniak BC, Park LS, Ziegler SF, Williams DE, Ware CB, Meyer JD, Davison BL. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J Exp Med. 1994;180:1955–60.

    CAS  PubMed  Google Scholar 

  • Petschner F, Zimmerman C, Strasser A, Grillot D, Nunez G, Pircher H. Constitutive expression of Bcl-xL or Bcl-2 prevents peptide antigen-induced T cell deletion but does not influence T cell homeostasis after a viral infection. Eur J Immunol. 1998;28:560–9.

    CAS  PubMed  Google Scholar 

  • Pipkin ME, Sacks JA, Cruz-Guilloty F, Lichtenheld MG, Bevan MJ, Rao A. Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells. Immunity. 2010;32:79–90.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Rathmell JC, Cooke MP, Ho WY, Grein J, Townsend SE, Davis MM, Goodnow CC. CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+ T cells. Nature. 1995;376:181–4.

    CAS  PubMed  Google Scholar 

  • Rathmell JC, Lindsten T, Zong WX, Cinalli RM, Thompson CB. Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis. Nat Immunol. 2002;3:932–9.

    CAS  PubMed  Google Scholar 

  • Rubinstein MP, Lind NA, Purton JF, Filippou P, Best JA, McGhee PA, Surh CD, Goldrath AW. IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response. Blood. 2008;112:3704–12.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Steimer DA, Boyd K, Takeuchi O, Fisher JK, Zambetti GP, Opferman JT. Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function. Blood. 2009;113:2805–15.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Strasser A. The role of BH3-only proteins in the immune system. Nat Rev Immunol. 2005;5:189–200.

    CAS  PubMed  Google Scholar 

  • Strasser A, Harris AW, Cory S. bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell. 1991a;67:889–99.

    CAS  PubMed  Google Scholar 

  • Strasser A, Whittingham S, Vaux DL, Bath ML, Adams JM, Cory S, Harris AW. Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proc Natl Acad Sci USA. 1991b;88:8661–5.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Strasser A, Harris AW, Corcoran LM, Cory S. Bcl-2 expression promotes B- but not T-lymphoid development in scid mice. Nature. 1994a;368:457–60.

    CAS  PubMed  Google Scholar 

  • Strasser A, Harris AW, von Boehmer H, Cory S. Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgene. Proc Natl Acad Sci USA. 1994b;91:1376–80.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Surh CD, Sprent J. Homeostasis of naive and memory T cells. Immunity. 2008;29:848–62.

    CAS  PubMed  Google Scholar 

  • Tarlinton DM, Corcoran LM, Strasser A. Continued differentiation during B lymphopoiesis requires signals in addition to cell survival. Int Immunol. 1997;9:1481–94.

    CAS  PubMed  Google Scholar 

  • Tomayko MM, Punt JA, Bolcavage JM, Levy SL, Allman DM, Cancro MP. Expression of the Bcl-2 family member A1 is developmentally regulated in T cells. Int Immunol. 1999;11:1753–61.

    CAS  PubMed  Google Scholar 

  • Tripathi P, Mitchell TC, Finkelman F, Hildeman DA. Cutting edge: limiting amounts of IL-7 do not control contraction of CD4+ T cell responses. J Immunol. 2007;178:4027–31.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Tripathi P, Kurtulus S, Wojciechowski S, Sholl A, Hoebe K, Morris SC, Finkelman FD, Grimes HL, Hildeman DA. STAT5 is critical to maintain effector CD8+ T cell responses. J Immunol. 2010;185:2116–24.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Williams MA, Tyznik AJ, Bevan MJ. Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells. Nature. 2006;441:890–3.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Wojciechowski S, Jordan MB, Zhu Y, White J, Zajac AJ, Hildeman DA. Bim mediates apoptosis of CD127(lo) effector T cells and limits T cell memory. Eur J Immunol. 2006;36:1694–706.

    CAS  PubMed  Google Scholar 

  • Wojciechowski S, Tripathi P, Bourdeau T, Acero L, Grimes HL, Katz JD, Finkelman FD, Hildeman DA. Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis. J Exp Med. 2007;204:1665–75.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Youle RJ, Strasser A. The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol. 2008;9:47–59.

    CAS  PubMed  Google Scholar 

  • Zhang N, He YW. The antiapoptotic protein Bcl-xL is dispensable for the development of effector and memory T lymphocytes. J Immunol. 2005;174:6967–73.

    CAS  PubMed  Google Scholar 

  • Zong WX, Lindsten T, Ross AJ, MacGregor GR, Thompson CB. BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak. Genes Dev. 2001;15:1481–6.

    CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, Division of Cellular and Molecular Immunology, Cincinnati Children’s Hospital Medical Center, S5. Rm 214 MLC 7038, 3333 Burnet Ave., Cincinnati, OH, 45229-3039, USA

    David Hildeman

  2. Division of Cellular and Molecular Immunology in the Department of Pediatrics, University of Cincinnati and Children’s Hospital Medical Center, Cincinnati, OH, 45229, USA

    David Hildeman, Jana Raynor & Sema Kurtulus

Authors
  1. David Hildeman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jana Raynor
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sema Kurtulus
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to David Hildeman .

Editor information

Editors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia

    Ian R. Mackay

  2. Center for Autoimmune Disease Research, Department of Molecular Microbiology and Immunology, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA

    Noel R. Rose

  3. The Feinstein Institute for Medical Research, Manhasset, NY, USA

    Betty Diamond

  4. The Feinstein Institute for Medical Research, Manhasset, NY, USA

    Anne Davidson

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Science+Business Media New York

About this entry

Cite this entry

Hildeman, D., Raynor, J., Kurtulus, S. (2014). Bcl-2 Family Members and Lymphocyte Homeostasis. In: Mackay, I.R., Rose, N.R., Diamond, B., Davidson, A. (eds) Encyclopedia of Medical Immunology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-84828-0_31

Download citation

  • DOI: https://doi.org/10.1007/978-0-387-84828-0_31

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-84827-3

  • Online ISBN: 978-0-387-84828-0

  • eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation