Skip to main content

Abstract:

Crohn’s disease is a chronic, relapsing disease with an often early age of onset that can affect the entire gastrointestinal tract. Crohn’s disease can have a debilitating effect on a patient’s social, educational, professional, and familial activities; thus having a profound effect on their health related quality of life (HRQOL). Only recently has an effort been made to determine the impact Crohn’s disease has on health related quality of life. Health related quality of life is a patient’s understanding of and relating to their illness within the scope of their lifestyle and in the process of doing so uses physical, psychological, cultural, educational, professional, and disease associated factors. Two types of instruments can be used to measure health related quality of life, general and disease specific, both of which look at various domains of a person’s life and must be validated, reproducible, and reliable. The health related quality of life of Crohn’s patients has been found to be significantly worse when compared to the healthy population. It is affected by various factors like disease activity, gender, medical and surgical treatment. It significantly affects the health related quality of life of adolescents in addition to the educational, familial, and professional aspirations of patients. Data on health related quality of life could provide valuable information on how to develop research protocols and alter treatment algorithms with the resolve of not only improving patient outcomes but also possibly improving utilization of resources.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 3,000.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 549.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

HRQOL:

Health related quality of life

IBD:

Inflammatory bowel disease

References

  • Afzal N, Van Der Zaag-Loonen H, Arnaud-Battandier F, Davies S, Murch S, Derkx B, Heuschkel R, Fell J. (2004). Aliment Pharmacol Ther. 20: 167–172.

    Article  PubMed  CAS  Google Scholar 

  • Andersson P, Olaison G, Bendtsen P, Myrelid P, Sjodahl R. (2003). Colorectal Dis. 5: 56–62.

    Article  PubMed  CAS  Google Scholar 

  • Bernkley T, Jahnsen J, Schulz T, Sauar J, Lygren I, Henriksen M, Stray N, Kjellevold O, Aadland E, Vatn M, Moum B. (2005). Eur J Gastroenterol Hepatol. 17: 1037–1045.

    Article  Google Scholar 

  • Binder V, Hendriksen C, Kreiner S. (1985). Gut. 26: 146–150.

    Article  PubMed  CAS  Google Scholar 

  • Blondel-Kucharski F, Chircop C, Marquis P, Cortot A, Baron F, Gendre JP, Colombel JF. (2001). Am J Gastroenterol. 96: 2915–2920.

    Article  PubMed  CAS  Google Scholar 

  • Calvet X, Gallardo O, Coronas R, Casellas F, Montserrat A, Torrejon A, Vergara M, Campo R, Brullet E. (2006). Inflamm Bowel Dis. 12: 692–696.

    Article  PubMed  Google Scholar 

  • Campieri M, Ferguson A, Doe W, Persson T, Nilsson LG. (1997). Gut. 41: 209–214.

    Article  PubMed  CAS  Google Scholar 

  • Canavan C, Abrams KR, Hawthorne B, Drossman D, Mayberry JF. (2006). Aliment Pharmacol Ther. 23: 377–385.

    Article  PubMed  CAS  Google Scholar 

  • Casellas F, Lopez-Vivancos J, Badia X, Vilaseca J, Malagelada JR. (2000). Am J Gastroenterol. 95: 177–182.

    Article  PubMed  CAS  Google Scholar 

  • Clemett D, Markham A. (2000). Drugs. 59: 929–956.

    Article  PubMed  CAS  Google Scholar 

  • Cohen RD. (2002). Aliment Pharmacol Ther. 16: 1603–1609.

    Article  PubMed  CAS  Google Scholar 

  • Delaney C, Kiran R, Senagore A, O’brien-Ermlich B, Church J, Hull T, Remzi F, Fazio V. (2003). J Am Coll Surg. 196: 714–721.

    Article  PubMed  Google Scholar 

  • Drossman D. (1993). In: Sleisenger MH, Fordtran JS (eds.) Gastrointestinal Disease: Pathophysiology, Diagnosis, and Management. WB Saunders, New York.

    Google Scholar 

  • Drossman DA, Patrick DL, Mitchell CM, Zagami EA, Appelbaum MI. (1989). Dig Dis Sci. 34: 1379–1386.

    Article  PubMed  CAS  Google Scholar 

  • Drossman DA, Leserman J, Li ZM, Mitchell CM, Zagami EA, Patrick DL. (1991). Psychosom Med. 53: 701–712.

    PubMed  CAS  Google Scholar 

  • Farmer RG, Easley KA, Farmer JM. (1992). Cleve Clini J Med. 59: 35–42.

    CAS  Google Scholar 

  • Feagan BG. (1999). Aliment Pharmacol Ther. 13(suppl. 4): 29–37.

    Article  PubMed  Google Scholar 

  • Ferguson A, Sedgwick DM, Drummond J. (1994). Gut. 35: 665–668.

    Article  PubMed  CAS  Google Scholar 

  • Griffiths AM, Nicholas D, Smith C, Munk M, Stephens D, Dumo C, Sherman PM. (1999). J Pediatr Gastroenterol Nutr. 28: S46–S52.

    Article  PubMed  CAS  Google Scholar 

  • Guthrie E, Jackson J, Shaffer J, Thompson D, Tomenson B, Creed F. (2002). Am J Gastroenterol. 97: 1994–1999.

    Article  PubMed  Google Scholar 

  • Guyatt G, Mitchell A, Irvine EJ, Singer J, Williams N, Goodacre R, Tompkins C. (1989). Gastroenterology. 96: 804–810.

    PubMed  CAS  Google Scholar 

  • Hay AR, Hay JW. (1992). J Clin Gastroenterol. 14: 318–327.

    Article  PubMed  CAS  Google Scholar 

  • Koelewijn C, Schrijvers A, Oldenburg B. (2006). Netherlands J Med. 64: 212–218.

    CAS  Google Scholar 

  • Lichtenstein GR, Yan S, Bala M, Hanauer S. (2004). Am J Gastroenterol. 99: 91–96.

    Article  PubMed  Google Scholar 

  • Lopez Blanco B, Moreno-Jimenez B, Devesa Mugica JM, Rodriguez Munoz A. (2005). Rev Esp Enferm Dig. 97: 887–898.

    Article  PubMed  CAS  Google Scholar 

  • Love JR, Irvine EJ, Fedorak RN. (1992). J Clini Gastroenterol. 14: 15–19.

    Article  CAS  Google Scholar 

  • Maunder RG, Cohen Z, McLeod RS, Greenberg GR. (1995). Dis. Colon Rectum. 38: 1147–1161.

    Article  PubMed  CAS  Google Scholar 

  • Mittermaier C, Dejaco C, Waldhoer T, Oefferlbauer-Ernst A, Miehsler W, Beier M, Tillinger W, Gangi A, Moser G. (2004). Psychosom Med. 66: 79–84.

    Article  PubMed  Google Scholar 

  • Moskovitz DN, Maunder RG, Cohen Z, McLeod RS, MacRae H. (2000). Dis Colon Rectum. 43: 517–521.

    Article  PubMed  CAS  Google Scholar 

  • Nicholas D, Otley A, Smith C, Avolio J, Munk M, Griffiths A. (2007). Health Qual Life Outcomes. 5L: 28.

    Article  Google Scholar 

  • Otley A, Smith C, Nicholas D, Munk M, Avolio J, Sherman PM, Griffiths AM. (2002). J Pediatr Gastroenterol Nutr. 35: 557–563.

    Article  PubMed  Google Scholar 

  • Otley A, Griffiths A, Hale S, Kugathasan S, Pfefferkorn M, Mezoff A, Rosh J, Tolia V, Markowitz J, Mack D, Oliva-Hemker M Wyllie R, Rothbaum R, Bousvaros A, Fernando Del Rosario J, Evans J, Blanchard W, Hyams J. (2006). Inflamm Bowel Dis. 12: 684–691.

    Article  PubMed  Google Scholar 

  • Prantera C, Cottone M, Pallone F, Annese V, Franze A, Cerutti R, Bianchi Porro G. (1999). Gastroenterol. 116: 521–526.

    Article  CAS  Google Scholar 

  • Rutgeerts P, Lofberg R, Malchow H, Lamers C, Olaison G, Jewell D, Danielsson A, Goebell H, Thomsen OO, Lorenz-Meyer H. (1994). N Engl J Med. 331: 842–845.

    Article  PubMed  CAS  Google Scholar 

  • Shorb PE. (1989). Gastroenerol Clin North Am. 18: 111–128.

    Google Scholar 

  • Sorensen VZ, Olsen BG, Binder V. (1987). Gut. 28: 382–385.

    Article  PubMed  CAS  Google Scholar 

  • Thirlby R, Land J, Fenster F, Lonborg R. (1998). Arch Surg. 133: 826–832.

    Article  PubMed  CAS  Google Scholar 

  • Thomsen OO, Cortot A, Jewell D, Wright JP, Winter T, Veloso FT, Vatn M, Persson T, Pettersson E. (1998). N Engl J Med. 339: 370–374.

    Article  PubMed  CAS  Google Scholar 

  • Thomsen OO, Cortot A, Jewell D, Wright JP, Winter T, Veloso FT, Vatn M, Persson T, Pettersson E. (2002). Am J Gastroenterol. 97: 649–653.

    Article  PubMed  CAS  Google Scholar 

  • Tillinger W, Mittermaier C, Lochs H, Moser G. (1999). Dig Dis Sci. 44: 932–938.

    Article  PubMed  CAS  Google Scholar 

  • WHO. (1998). WHOQOL User Manual. Geneva: World Health Organization.

    Google Scholar 

  • Yazdanpanah Y, Klein O, Gambiez L, Baron P, Desreumaux P, Marquis P, Cortot A, Quandalle P, Colombel JF. (1997). Am J Gastroenterol. 92: 1897–1900.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer Science+Business Media LLC

About this entry

Cite this entry

Wexner, S.D., Frattini, J.C. (2010). Quality of Life in Crohn’s Disease. In: Preedy, V.R., Watson, R.R. (eds) Handbook of Disease Burdens and Quality of Life Measures. Springer, New York, NY. https://doi.org/10.1007/978-0-387-78665-0_127

Download citation

  • DOI: https://doi.org/10.1007/978-0-387-78665-0_127

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-78664-3

  • Online ISBN: 978-0-387-78665-0

  • eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics