Abstract
Approximately, 200,000 people in the United States have spinal cord injuries (SCI), and some 10,000 new injuries occur annually. Most new victims are between 18 and 30 years old. The lifetime costs of paraplegia for such patients can exceed several million dollars in medical support and lost wages. The potential mechanisms of injury include compression, distraction, acceleration–deceleration, and shearing forces, as well as direct section from penetrating injuries.
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References
Allen AR. Surgery of experimental lesion of spinal cord equivalent to crush injury of fracture dislocation of spinal column. A preliminary report. JAMA. 1911;57:878–880.
Hung TK, Albin MS, Brown TD, Bunegin L, Albin R, Jannetta PJ. Biomechanical responses to open experimental spinal cord injury. Surg Neurol. 1975;4:271–276.
Wallace MC, Tator CH, Lewis AJ. Chronic regenerative changes in the spinal cord after cord compression injury in rats. Surg Neurol. 1987;27:209–219.
Young W. The post-injury responses in trauma and ischemia: secondary injury or protective mechanisms? Cent Nerv Syst Trauma. 1987;4:27–51.
Young W. Secondary CNS injury. J Neurotrauma. 1988;5:219–221.
Tator CH, Fehlings MG. Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms. J Neuorsurg. 1991;75:15–26.
Tator CH. Ischemia as a secondary neuronal injury. New York: Oxford University Press; 1994.
Tator CH. Experimental and clinical studies of the pathophysioÂlogy and management of acute spinal cord injury. J Spinal Cord Med. 1996;19:206–214.
Geisler F, editor. Past and current human spinal cord injury drug trials: American Association of Neurological Surgeons Publication Committee; 1995.
Geisler FH. Clinical trials of pharmacotherapy for spinal cord injury. Ann N Y Acad Sci. 1998;845:374–381.
Bracken M. Pharmacological interventions for acute spinal cord injury. Cochrane Database Syst Rev. 2000;2:CD001046.
Tator CH, Fehlings MG. Review of clinical trials of neuroprotection in acute spinal cord injury. Neurosurg Focus. 1999;6(1):e8.
Steeves JD, Lammertse D, Curt A, Fawcett JW. Experimental treatments for spinal cord injury: what you should know. International Campaign for Cures of spinal cord injury Paralysis (ICCP). Vancouver, Ca. 2007. ISBN 978-0-9782959-0-5.
Bracken MB. Methylprednisolone in the management of acute spinal cord injuries. Med J Aust. 1990;153:368.
Steroids after spinal cord injury. Lancet 1990;336:279–280.
Bracken MB, Shepard MJ, Collins WF, et al. A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study. N Engl J Med. 1990;322:1405–1411.
Bracken MB. Treatment of acute spinal cord injury with methylprednisolone: results of a multicenter, randomized clinical trial. J Neurotrauma. 1991;8(Suppl 1):S47–S50. discussion S51–S52.
Bracken MB, Shepard MJ, Collins WF Jr, et al. Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study. J Neurosurg. 1992;76:23–31.
Bracken MB, Holford TR. Effects of timing of methylprednisolone or naloxone administration on recovery of segmental and long-tract neurological function in NASCIS 2. J Neurosurg. 1993;79:500–507.
Otani K, Kadoya S, et al. Beneficial effect of methylprednisolone sodium succinate in the treatment of acute spinal cord injury. Sekitsui Sekizui J. 1994;7:633–647.
Bracken MB, Shepard MJ, Holford TR, et al. Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study. JAMA. 1997;277:1597–1604.
Bracken MB, Shepard MJ, Holford TR, et al. Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the third National Acute Spinal Cord Injury randomized controlled trial. J Neurosurg. 1998;89:699–706.
Geisler FH, Dorsey FC, Coleman WP. Correction: recovery of motor function after spinal-cord injury – a randomized, placebo-controlled trial with GM-1 ganglioside. N Engl J Med. 1991;325:1659–1660.
Geisler FH, Dorsey FC, Coleman WP. Recovery of motor function after spinal-cord injury – a randomized, placebo-controlled trial with GM-1 ganglioside. N Engl J Med. 1991;324:1829–1838.
Geisler FH, Dorsey FC, Coleman WP. GM-1 ganglioside in human spinal cord injury. J Neurotrauma. 1992;9(suppl 1):S407–S416.
Geisler FH. GM-1 ganglioside and motor recovery following human spinal cord injury. J Emerg Med. 1993;11(Suppl 1):49–55.
Geisler FH, Dorsey FC, Coleman WP. Past and current clinical studies with GM-1 ganglioside in acute spinal cord injury. Ann Emerg Med. 1993;22:1041–1047.
Geisler FH, Dorsey FC, Patarnello F, Grieco G, Poonian D, Fiorentini R. SYGEN acute spinal cord injury study (abstract). J Neurotrauma. 1998;15:868.
Bracken MB, Collins WF, Freeman DF, et al. Efficacy of methylprednisolone in acute spinal cord injury. JAMA. 1984;251:45–52.
Bracken MB, Shepard MJ, Hellenbrand KG, et al. Methylprednisolone and neurological function 1 year after spinal cord injury. Results of the National Acute Spinal Cord Injury Study. J Neurosurg. 1985;63:704–713.
Bracken MB. Pharmacological treatment of acute spinal cord injury: current status and future projects. J Emerg Med. 1993;11(Suppl 1):43–48.
Eck JC, Nachtigall D, Humphreys SC, Hodges SD. Questionnaire survey of spine surgeons on the use of methylprednisolone for acute spinal cord injury. Spine. 2006;31:E250–E253.
Taylor TK, Ryan MD. Methylprednisolone in the management of acute spinal cord injuries. Med J Aust. 1990;153:307–308.
Rosner MJ. National acute spinal cord injury study of methylprednisolone or naloxone. Neurosurgery. 1991;28:628–629.
Rosner MJ. Methylprednisolone for spinal cord injury. J Neurosurg. 1992;77:324–325. discussion 325–327.
Shapiro SA. Methylprednisolone for spinal cord injury. J Neurosurg. 1992;77:324. discussion 325–327.
Rosner MJ. Treatment of spinal cord injury. J Neurosurg. 1994;80:954–955.
Ducker TB. Medical treatment in spinal cord injuries. J Spinal Disord. 1996;9:381.
Hardy R. Commentary on spinal cord injury: role of steroid therapy. Neurosurg Quart. 1996;6:71–72.
Hanigan WC, Anderson RJ. Commentary on NASCIS-2. J Spinal Disord. 1992;5:125–131. discussion 132–133.
Ducker TB, Zeidman SM. Spinal cord injury. Role of steroid therapy. Spine. 1994;19:2281–2287.
Nesathurai S. Steroids and spinal cord injury: revisiting the NASCIS 2 and NASCIS 3 trials. J Trauma. 1998;45:1088–1093.
Coleman WP, Benzel E, Cahill DW, et al. A critical appraisal of the reporting of the NASCIS II and III studies of MPSS in acute spinal cord injury. J Spinal Disord. 2000;13(3):185–199.
Hurlbert RJ. Methylprednisolone for acute spinal cord injury: an inappropriate standard of care. J Neurosurg. 2000;93:1–7.
Nesathurai S. Steroids and spinal cord injury: revisiting the NASCIS 2 and NASCIS 3 trials. J Trauma. 1998;45:1088–1093.
Short DJ, El Masry WS, Jones PW. High dose methylprednisolone in the management of acute spinal cord injury: a systematic review from a clinical perspective. Spinal Cord. 2000;38:273–286.
Hurlbert RJ. The role of steroids in acute spinal cord injury: an evidence-based analysis. Spine. 2001;26(24S):S39–S46.
Hadley MN, Walters BC. “Pharmacological therapy after acute cervical spinal cord injury” in Guidelines for the management of acute cervical spine and spinal cord injuries. Neurosurgery. 2002;50:S63–S72.
Hugenholtz H. Methylprednisolone for acute spinal cord injury: not a standard of care. CMAJ. 2003;168:1145–1146.
Hurlbert RJ. Strategies of medical intervention in the management of acute spinal cord injury. Spine. 2006;31:S16–S21.
Sayer FT, Kronvall E, Nilsson OG. Methylprednisolone treatment in acute spinal cord injury: the myth challenged through a structured analysis of published literature. Spine J. 2006;6:335–343.
Edwards P, Arango M, Balica L, et al. Final results of MRC CRASH, a randomised placebo-controlled trial of intravenous corticosteroid in adults with head injury-outcomes at 6 months. Lancet. 2005;365:1957–1959.
Geisler FH, Dorsey FC, Coleman WP. GM-1 ganglioside in human spinal cord injury. J Neurotrauma. 1992;9(suppl 2):S517–S530.
Geisler FH, Coleman WP, Dorsey FC, Grieco G, Poonian D. Recruitment and early care after acute spinal cord injury. Spine. 2001;26(24S):58–67.
Geisler FH, Coleman WP, Dorsey FC, Grieco G, Poonian D. Measurement and recovery after acute spinal cord injury. Spine. 2001;26(24S):68–86.
Geisler FH, Coleman WP, Dorsey FC, Grieco G, Poonian D. A multi-center trial of GM-1 ganglioside in acute spinal cord injury. Spine. 2001;26(24S):87–98.
Oleson CV, Burns AS, Ditunno JF, Geisler FH, Coleman WP. Prognostic value of pinprick preservation in motor complete, sensory incomplete spinal cord injury. Arch Phys Med Rehabil. 2005;86:988–992.
Fawcett JW, Curt A, Steeves JD, Coleman WP. Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: spontaneous recovery after spinal cord injury and statistical power needed for therapeutic clinical trials. Spinal Cord. 2007;45:190–205.
Steeves JD, Lammertse D, Curt A, Fawcett JW. Guidelines for the conduct of clinical trials for spinal cord injury (SCI) as developed by the ICCP panel: clinical trial outcome measures. Spinal Cord. 2007;45:206–221.
Tadie M, et al. Early care and treatment with a neuroprotective drug, gacyclidine, in patients with acute spinal cord injury. Rachis. 2003;15:363–376.
Pitts LH, Ross A, Chase GA, Faden AI. Treatment with thyrotropin-releasing hormone (TRH) in patients with traumatic spinal cord injuries. J Neurotrauma. 1995;12:235–243.
Petitjean ME, Pointillart V, Dixmerias F, et al. Medical treatment of spinal cord injury in the acute stage. Ann Fr Anesth Reanim. 1998;17:114–122.
Knoller N, Auerbach G, Fulga V, Zelig G. Clinical experience using incubated macrophages as a treatment for complete spinal cord injury: phase I study results. J Neurosurg Spine. 2005;3:173–181.
Segal JL, Hayes KC, Brunnemann SR, et al. Absorption characteristics of sustained-release 4-aminopyridine (fampridine SR) in patients with chronic spinal cord injury. J Clin Pharmacol. 2000;40:402–409.
Potter PJ, Hayes KC, Segal JL, et al. Randomized double-blind crossover trial of fampridine-SR (sustained release 4 aminopyridine) in patients with incomplete spinal cord injury. J Neurotrauma. 1998;10:837–849.
Cardenas DD, Ditunno J, Graziani V, et al. Phase 2 trial of sustained-release fampridine in chronic spinal cord injury. Spinal Cord. 2007;45(2):158–168.
Borgens RB, Blight AR, McGinnis ME. Functional recovery after spinal cord hemisection in Guinea pigs: the effects of applied electric fields. J Comp Neurol. 1990;296:634–653.
Borgens RB, Toombs JP, Blight AR, et al. Effects of applied electric fields on clinical cases of complete paraplegia in dogs. Restor Neurol Neurosci. 1993;5:305–322.
Borgens RB, Toombs JP, Breur G, et al. An imposed oscillating electrical field improves the recovery of function in neurologically complete paraplegic dogs. J Neurotrauma. 1999;16(7):639–657.
Shapiro S, Borgens R, Pascuzzi R, et al. Oscillating field stimulation for complete spinal cord injury in humans: a phase I trial. J Neurosurg Spine. 2005;2:3–10.
Walters BC, Coleman WP, Shapiro SA, Borgens RB, Geisler FH. Comparison of outcomes of oscillating field stimulation in AIS a patients to spontaneous recovery alone. Presented at the 24th Annual Meeting of the AANS/CNS Section on Disorders of the Spine and Peripheral Nerves, Orlando, Florida, March 1, 2008.
Fehlings MG, Tator CH. An evidence-based review of decompressive surgery in acute spinal cord injury: rationale, indications, and timing based on experimental and clinical studies. J Neurosurg. 1999;91(1 suppl):1–11.
Kirshblum S. New rehabilitation interventions in spinal cord injury. J Spinal Cord Med. 2004;27:342–350.
Gaunt RA, Prochazka A. Control of urinary bladder function with devices: successes and failures. Prog Brain Res. 2006;152:163–194.
Dunham CM, Cowley RA. Shock trauma/critical care handbook. Rockville, MD: Aspen Publishers; 1986.
Levine AM, editor. Acute spinal injury. Orthop Clin North Am. 1986;17:1–203.
Benzel EC, Tator CH, editors. Contemporary management of spinal cord injury. Park Ridge, IL: American Association of Neurological Surgeons; 1995.
Capen DA, Haye W. Comprehensive management of spine trauma. St. Louis: Mosby; 1998.
Levine AM, Eismont FJ, Garfin SR. Spine trauma. Philadelphia: Saunders; 1998.
International Standards for Neurological Classification of Spinal Cord Injury. Chicago: American Spinal Injury Association; 2000, reprinted 2002.
Reference Manual for the International Standards for Neurological Classification of Spinal Cord Injury. Chicago: American Spinal Injury Association; 2003.
Anderson KD. Targeting recovery: priorities of the spinal cord-injured population. J Neurotrauma. 2004;21(10):1371–1383.
Hamilton BB, Fuhrer MJ. Rehabilitation outcomes: analysis and measurement. Baltimore: Brooks; 1987.
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Geisler, F.H., Coleman, W.P. (2010). Spinal Cord Injuries. In: O’Donnell, J.M., Nácul, F.E. (eds) Surgical Intensive Care Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-77893-8_14
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