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Mouse Models of Pancreatic Exocrine Cancer

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Pancreatic Cancer

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Abstract:

Pancreatic ductal adenocarcinoma (PDA) is a common and lethal disease. Despite the prevalence of PDA, our understanding of the critical events underlying disease pathogenesis and therapeutic resistance is woefully inadequate. To accelerate progress, much effort has been directed at recapitulating PDA in suitable animal models. Early efforts to model PDA in rodents utilized chemical carcinogenesis, and although useful for certain applications, crucial limitations prevented their widespread utility. Traditional transgenic approaches also failed to produce accurate models of pancreatic cancer in mice, potentially due to the non-physiological control of gene expression. The advent of gene targeting in embryonic stem cells and a deeper understanding of the molecular and cellular events that occur during pancreatic neoplasia enabled the development of accurate models of pre-invasive and invasive PDA. Such models are now yielding fruitful information of direct relevance to patients with pancreatic cancer.

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    Michelle Lockley

  2. Cancer Research UK, Cambridge, UK

    David Tuveson

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Lockley, M., Tuveson, D. (2010). Mouse Models of Pancreatic Exocrine Cancer. In: Pancreatic Cancer. Springer, New York, NY. https://doi.org/10.1007/978-0-387-77498-5_20

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