Skip to main content

Glaucoma Risk Factors: Ethnicity and Glaucoma

  • Chapter
  • First Online:
The Glaucoma Book

Abstract

The diagnosis of glaucoma of primary open-angle glaucoma requires the evaluation of multiple ophthalmic characte­ristics. Additionally, it is usefully to identify accompanying demographic factors that suggest populations at risk for the disease. The risk of the development and/or the progression of glaucoma can be influenced by the patient’s race, age, family history of glaucoma, intraocular pressure, central corneal thickness, and presence of certain systemic diseases. Epidemiologic studies have enabled us to better understand those features that place a patient at increased risk for the development of glaucomatous optic neuropathy. Studies have also highlighted that racial differences not only exist in the prevalence and incidence of glaucoma but also in those ophthalmic features that are critical in glaucoma detection. Succeeding chapters will focus explicitly on the diagnosis and management of various forms of glaucoma. In this chapter, we describe how the results of various epidemiologic studies, particularly as they relate to race and ethnicity, maybe used in the evaluation of the individual patient.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 219.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 279.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Tielsch JM, Sommer A, Katz J, et al. Racial variations in the prevalence of primary open-angle glaucoma: the Baltimore Eye Survey. JAMA. 1991;226:369–374.

    Article  Google Scholar 

  2. Leske MC, Connell AM, Schachat AP, et al. The Barbados Eye Study: prevalence of open-angle glaucoma. Arch Ophthalmol. 1994;112:821–829.

    CAS  PubMed  Google Scholar 

  3. Mason RP, Kosoko O, Wilson MR, et al. National survey of the prevalence and risk factors of glaucoma in St Lucia, West Indies. Part 1: prevalence findings. Ophthalmology. 1989;96:1363–1368.

    CAS  PubMed  Google Scholar 

  4. Topouzis F, Wilson MR, Harris A, et al. Prevalence of open-angle glaucoma in Greece: the Thessaloniki Eye Study. Am J Ophthalmol. 2007;144(4):511–519.

    Article  PubMed  Google Scholar 

  5. Varma R, Ying-Lai M, Francis BA, et al. The Los Angeles Latino Eye Study: prevalence of open-angle glaucoma and ocular hypertension in Latinos. Ophthalmology. 2004;111:1439–1448.

    Article  PubMed  Google Scholar 

  6. Quigley HA, West SK, Rodriguez J, et al. The prevalence of glaucoma in a population-based study of Hispanic subjects: Proyecto VER. Arch Ophthalmol. 2001;119:1819–1826.

    CAS  PubMed  Google Scholar 

  7. Iwase A, Suzuki Y, Araie M, et al. The prevalence of primary open-angle glaucoma in Japanese: The Tajimi Study. Ophthalmology. 2004;111:1641–1648.

    PubMed  Google Scholar 

  8. Hu Z, Zhao ZL, Dong FT, et al. An epidemiologic investigation of glaucoma in Beijing and Shun-yi County. Chin J Ophthalmol. 1989;25:115–118.

    CAS  Google Scholar 

  9. Wensor MD, McCarty CA, Stanislavsky YL, et al. The prevalence of glaucoma in the Melbourne Visual Impairment Project. Ophthalmology. 1998;105:733–739.

    Article  CAS  PubMed  Google Scholar 

  10. Vijaya L, George R, Baskaran M, et al. Prevalence of primary open-angle glaucoma in an urban south Indian population and comparison with a rural population: The Chennai Glaucoma Study. Ophthalmology. 2008;115(4):648–654.

    Article  PubMed  Google Scholar 

  11. Mitchell P, Smith W, Attebo K, et al. Prevalence of open-angle glaucoma in Australia: The Blue Mountains Eye Study. Ophthalmology. 1996;103:1661–1669.

    CAS  PubMed  Google Scholar 

  12. Eye Diseases Prevalence Research Group. Prevalence of open-angle glaucoma among adults in the United States. Arch Ophthalmol. 2004;122:532–538.

    Article  Google Scholar 

  13. Friedman DS, Jampel HD, Munoz B, et al. The prevalence of open-angle glaucoma among blacks and white 73 years and older: The Salisbury Eye Evaluation Glaucoma Study. Arch Ophthalmol. 2006;124:1625–1630.

    Article  PubMed  Google Scholar 

  14. Klein BE, Klein R, Sponsel WE, et al. Prevalence of glaucoma: The Beaver Dam Eye Study. Ophthalmology. 1992;22:1499–1504.

    Google Scholar 

  15. He M, Foster P, Ge J, et al. Prevalence and clinical characteristics of glaucoma in adult Chinese: a population-based study in Liwan District, Guangzhou. Invest Ophthalmol Vis Sci. 2006;47:2782–2788.

    Article  PubMed  Google Scholar 

  16. Leske MC, Wu SY, Honkanen R, et al. Nine-year incidence of open-angle glaucoma in the Barbados Eye Studies. Ophthalmology. 2007;114:1058–1064.

    Article  PubMed  Google Scholar 

  17. Mukesh BN, McCarty A, Rait J, et al. Five-year incidence of open-angle glaucoma: The Visual Impairment Project. Ophthalmology. 2002;109:1047–1051.

    Article  PubMed  Google Scholar 

  18. deVoogd S, Ikram MK, Wolfs RC, et al. Incidence of open-angle glaucoma in a general elderly population: The Rotterdam Study. Ophthalmology. 2005;112:1487–1493.

    Article  Google Scholar 

  19. Mitchell P, Lee AJ, Rochtchina E, et al. 10-Year incidence and progression of open-angle glaucoma in an older population: the Blue Mountains Eye Study. Invest Ophthalmol Vis Sci 2006;47:E-Abstract 2342.

    Google Scholar 

  20. Sommer A, Tielsch JM, Katz J, et al. Relationship between intraocular pressure and primary open angle glaucoma among white and black Americans. The Baltimore Eye Survey. Arch Ophthalmol. 1991;109:1090–1095.

    CAS  PubMed  Google Scholar 

  21. Sommer A. Glaucoma: facts and fancies. Eye. 1996;10:295–301.

    PubMed  Google Scholar 

  22. Wormald RPL, Basauri E, Wright LA, et al. The African Caribbean eye survey: risk factors for glaucoma in a sample African Caribbean people living in London. Eye. 1994;8:315–320.

    PubMed  Google Scholar 

  23. Kass MA, Heuer DK, Higginbotham EJ, et al. The Ocular Hypertension Treatment Study: a randomized trail determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma. Arch Ophthalmol. 2002;120:701–713.

    PubMed  Google Scholar 

  24. Heijl A, Leske C, Bengtsson B, et al. Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial. Arch Ophthalmol. 2002;120:1268–1279.

    PubMed  Google Scholar 

  25. Collaborative Normal Tension Glaucoma Study Group. The effectiveness of intraocular pressure reduction in the treatment of normal-tension glaucoma. Am J Ophthalmol. 1998;126:498–505.

    Article  Google Scholar 

  26. The Advanced Glaucoma Intervention Study (AGIS): 7. The relationship between control of intraocular pressure and visual field deterioration. The AGIS Investigators. Am J Ophthalmol 2000;130:429–440.

    Article  Google Scholar 

  27. Coulehan JL, Helzlsouer KJ, Rogers KD, et al. Racial differences in intraocular tension and glaucoma surgery. Am J Epidemiol. 1980;111:759–768.

    CAS  PubMed  Google Scholar 

  28. Martin MJ, Sommer A, Gold EB, et al. Race and primary open-angle glaucoma. Am J Ophthalmol. 1985;99:383–387.

    CAS  PubMed  Google Scholar 

  29. David R, Livingston D, Luntz MH. Ocular hypertension: a comparative follow-up of black and white patients. Br J Ophthalmol. 1978;62:676–678.

    Article  CAS  PubMed  Google Scholar 

  30. Gordon MO, Kass MA. The Ocular Hypertension Treatment Study: design and baseline description of the participants. Arch Ophthalmol. 1999;117:573–583.

    CAS  PubMed  Google Scholar 

  31. Leske MC, Connell AM, Wu SY, et al. Risk factors for open-angle glaucoma. The Barbados Eye Study. Arch Ophthalmol. 1995;113:918–924.

    CAS  PubMed  Google Scholar 

  32. Wilson R, Richardson TM, Hertzmark E, et al. Race as a risk factor for progressive glaucomatous damage. Ann Ophthalmol. 1985;17:653–659.

    CAS  PubMed  Google Scholar 

  33. AGIS: The Advanced Glaucoma Intervention Study (AGIS): 3. Baseline characteristics of black and white patients. Ophthalmol 1998;105:1137–1145.

    Article  Google Scholar 

  34. Johnson M, Kass MA, Moses RA, et al. Increased corneal thickness stimulating elevated intraocular pressure. Arch Ophthalmol. 1978;96:664–665.

    CAS  PubMed  Google Scholar 

  35. Doughty MJ, Zaman ML. Human corneal thickness and its impact on intraocular pressure measures: a review and metaanalysis approach. Surv Ophthalmol. 2000;44:367–408.

    Article  CAS  PubMed  Google Scholar 

  36. Kniestedt C, Lin S, Choe J, et al. Clinical comparison of contour and applanation tonometry and their relationship to pachymetry. Arch Ophthalmol. 2005;123:1532–1537.

    Article  PubMed  Google Scholar 

  37. Brandt JD, Beiser JA, Kass MA, et al. Central Corneal thickness in the Ocular Hypertension Treatment Study (OHTS). Ophthalmology. 2001;108:1779–1788.

    Article  CAS  PubMed  Google Scholar 

  38. Ducker DK, Singh K, Lin SC, et al. Corneal thickness measurement in the management of primary open-angle glaucoma; a report by the American Academy of Ophthalmology. Ophthalmology. 2007;114:1779–1787.

    Article  Google Scholar 

  39. LaRosa FA, Gross RL, Orengo-Nania S. Central corneal thickness of caucasians and African Americans in glaucomatous and nonglaucomatous populations. Arch Ophthalmol. 2001;119:23–27.

    CAS  Google Scholar 

  40. Suzuki S, Suzuki Y, Iwase A, et al. Corneal thickness in an ophthalmologically normal Japanese population. Ophthalmology. 2005;112:1327–1336.

    Article  PubMed  Google Scholar 

  41. Lee ES, Kim CY, Ha SJ, et al. Central corneal thickness of Korean patients with glaucoma. Ophthalmology. 2007;114:927–930.

    Article  PubMed  Google Scholar 

  42. Gordon MO, Breiser JA, Brandt JD, et al. The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma. Arch Ophthalmol. 2002;120:714–720.

    PubMed  Google Scholar 

  43. Armaly MF, Krueger DE, Maunder L, et al. Biostatistical analysis of the collaborative glaucoma study. I. Summary report of the risk factors for glaucomatous visual-field defects. Arch Ophthalmol. 1980;98:2163–2171.

    CAS  PubMed  Google Scholar 

  44. Hart WM, Yablonski M, Kass MA, Becker B. Multivariate analysis of the risk of glaucomatous visual field loss. Arch Ophthalmol. 1979;97:1455–1458.

    PubMed  Google Scholar 

  45. Yablonski ME, Zimmerman TJ, Kass MA, Becker B. Prognostic significance of optic disc cupping in ocular hypertensive patients. Am J Ophthalmol. 1980;89:585–592.

    CAS  PubMed  Google Scholar 

  46. Chi T, Ritch R, Stickler D, et al. Racial differences in optic nerve head parameters. Arch Ophthalmol. 1989;107:836–839.

    CAS  PubMed  Google Scholar 

  47. Mansour AM. Racial variation of optic disc size. Ophthalmic Res. 1991;23:67–72.

    Article  CAS  PubMed  Google Scholar 

  48. Tsai CS, Zangwill L, Gonzalez C, et al. Ethnic differences in optic nerve head topography. J Glaucoma. 1995;4:248–257.

    CAS  PubMed  Google Scholar 

  49. Varma R, Tielsch JM, Qjuigley HA, et al. Race-, age-, gender-, and refractive error-related differences in normal optic disc. Arch Ophthalmol. 1994;112:1068–1076.

    CAS  PubMed  Google Scholar 

  50. Beck RW, Messner DK, Musch DC, et al. Is there a racial difference in physiologic cup size? Ophthalmology. 1985;92:873–876.

    CAS  PubMed  Google Scholar 

  51. Jonas JB, Gusek GC, Naumann GO. Optic disc, cup and neuroretinal rim size, configuration and correlations in normal eyes. Invest Ophthalmol Vis Sci. 1988;29:1151–1158.

    CAS  PubMed  Google Scholar 

  52. Caprioli J, Miller JM. Optic disc rim area is related to disc size in normal subjects. Arch Ophthalmol. 1987;105:1683–1685.

    CAS  PubMed  Google Scholar 

  53. Poinooswmy D, Fontana L, Wu JX, et al. Variations of nerve fiber layer thickness measurements with age and ethnicity by scanning laser polarimetry. Br J Ophthalmol. 1997;81:350–354.

    Article  Google Scholar 

  54. Tjon-Fo Sang MJ, Lemij HG. Retinal nerve fiber layer measurements in normal blacks subjects as determined with scanning laser polarimetry. Ophthalmology. 1998;105:78–81.

    Article  CAS  PubMed  Google Scholar 

  55. Racette L, Boden C, Kleinhandler SL. Differences in visual function and optic nerve structure between healthy eyes of blacks and whites. Arch Ophthalmol. 2005;123:1547–1553.

    Article  PubMed  Google Scholar 

  56. Mitchell P, Hourihan F, Sandbach J, et al. The relationship between glaucoma and myopia: the Blue Mountains Eye Study. Ophthalmology. 1999;106:2010–2015.

    Article  CAS  PubMed  Google Scholar 

  57. Wong TY, Klein BE, Klein R, et al. Refractive errors, intraocular pressure, and glaucoma in a white population. Ophthalmology. 2003;110:211–217.

    Article  PubMed  Google Scholar 

  58. Wu SY, Nemesure B, Leske MC. Barbados Eye Study Group. Refractive errors in black a black adult population: the Barbados Eye Study. Invest Ophthalmol Vis Sci. 1999;40:2179–2184.

    CAS  PubMed  Google Scholar 

  59. Suzuki Y, Iwase A, Araie M, et al. Risk factors for open-angle glaucoma in a Japanese population. The Tajimi Study. Ophthalmology. 2006;113:1613–1617.

    Article  PubMed  Google Scholar 

  60. Leske MC, Heijl A, Hussein M, et al. Factors for glaucoma progression and the effect of treatment: the Early Manifest Glaucoma Trial. Arch Ophthalmol. 2003;121(1):48–56.

    PubMed  Google Scholar 

  61. Jonas JB, Gusek GC, Naumann GO. Optic disk morphometry in high myopia. Graefes Arch Clin Exp Ophthalmol. 1998;226:587–590.

    Article  Google Scholar 

  62. Jonas JB, Nguyen XN, Gusek GC, Naumann GOH. Parapapillary chorioretinal atrophy in normal and glaucoma eyes. I. Morphometric date. Invest Ophthalmol Vis Sci. 1989;30:908.

    CAS  PubMed  Google Scholar 

  63. Primrose J. Early signs of glaucomatous disc. Br J Ophthalmol. 1971;55:820.

    Article  CAS  PubMed  Google Scholar 

  64. Wilensky JT, Kolker AE. Peripapillary changes in glaucoma. Am J Ophthalmol. 1976;81:341.

    CAS  PubMed  Google Scholar 

  65. Hoh S, Lim MC, Seah SK. Peripapillary retinal nerve fiber layer thickness variation in myopia. Ophthalmology. 2006;113:773–777.

    Article  PubMed  Google Scholar 

  66. Tielsch JM, Katz J, Quigley HA, et al. Diabetes, intraocular pressure, and primary open-angle glaucoma in the Baltimore Eye Survey. Ophthalmology. 1995;102:48–53.

    CAS  PubMed  Google Scholar 

  67. Leske MC, Wu S, Hennis A. Risk factors for incident open-angle glaucoma: the Barbados Eye Studies. Ophthalmology. 2008;115(1):85–93.

    Article  PubMed  Google Scholar 

  68. Chopra V, Varma R, Francia BA. Type 2 diabetes mellitus and the risk of open-angle glaucoma: the Los Angles Latino Eye Study. Ophthalmology. 2008;115(2):227–232.

    Article  PubMed  Google Scholar 

  69. European Glaucoma Prevention (EGPS) Group. Predictive factors for open-angle glaucoma among patients with ocular hypertension in the European Glaucoma Prevention Study. Ophthalmology. 2007;114:3–9.

    Article  Google Scholar 

  70. Leske MC, Wu SY, Nemesure B, et al. Incident open-angle glaucoma and blood pressure. Arch Ophthalmol. 2002;120:954–959.

    PubMed  Google Scholar 

  71. Tielsch JM, Katz J, Sommer A, et al. Hypertension, perfusion pressure, and primary open-angle glaucoma; a population based assessment. Arch Ophthalmol. 1995;113:216–221.

    CAS  PubMed  Google Scholar 

  72. Mitchell P, Lee AJ, Rochtchna E, et al. Open-angle glaucoma and systemic hypertension; the Blue Mountains Eye Study. J Glaucoma. 2004;13:319–326.

    Article  PubMed  Google Scholar 

Bibliography

  • Chopra, V., R. Varma, B.A. Francis, et al. 2008. Type 2 diabetes mellitus and the risk of open-angle glaucoma. The Los Angeles Latino Eye Study. Ophthalmology. 115: 227–232.

    Article  PubMed  Google Scholar 

  • Cotter SA, Varma R, Ying-Lai M, et al. Causes of low vision and blindness in adult latinos. The Los Angeles Latino Eye Study. Ophthalmology. 2006;113:1574–1582. www.nei.nih.gov/latinoeyestudy/.

    Google Scholar 

  • Doshi, V., M. Ying-Lai, S.P. Azen, et al. 2008. Sociodemographic, family history, and lifestyle risk factors for open-angle glaucoma and ocular hypertension The Los Angeles Latino Eye Study. Ophthalmology. 115: 639–647.

    Article  PubMed  Google Scholar 

  • Leske, M.C. 1983. The epidemiology of open-angle glaucoma: a review. Am J Epidemiol. 118: 166–191.

    CAS  PubMed  Google Scholar 

  • Memarzadeh, F., M. Ying-Lai, S.P. Azen, et al. 2008. Associations with intraocular pressure in Latinos: The Los Angeles Latino Eye Study. Am J Ophthalmol. 146: 69–76.

    Article  PubMed  Google Scholar 

  • Quigley, H.A., S. West, J. Rodriquez, et al. 2001. The prevalence of glaucoma in a population-based study of Hispanic subjects (Proyecto VER). Arch Ophthalmol. 119: 1819–1826.

    CAS  PubMed  Google Scholar 

  • Rodriguez J, Sanchez R, Munoz B, et al. Causes of blindness and visual impairment in a population-based sample of U.S. Hispanics. Ophthalmology. 2002;109:737–743.

    Google Scholar 

  • Tielsch, J.M., A. Sommer, J. Katz, et al. 1991. Racial variations in the prevalence of primary open-angle glaucoma. The Baltimore Eye Survey. JAMA. 266: 369–374.

    CAS  Google Scholar 

  • U.S. Census Bureau. (NP-T4-F) Projections of the total resident population by 5-year age groups, race and Hispanic origin with special age categories: middle series, 2025 to 2045. Available at: http://www.census.gov/population/projections/nation/summary/np-t4-f.pdf. Accessed February 4, 2004.

  • U.S. Census Bureau. Current population reports. Population projections of the United States by age, sex, race and Hispanic origin: 1995 to 2050. P25-1130. 1996. Available at: http://www.census.gov/prod/1/pop/p25-1130/p251130.pdf. Accessed February 4, 2004.

  • Varma, R., M. Ying-Lai, B.A. Francis, et al. 2004. Prevalence of open-angle glaucoma and ocular hypertension in Latinos: The Los Angeles Latino Eye Study. Ophthalmology. 111: 1439–1448.

    Article  PubMed  Google Scholar 

  • West, S.K., B. Munoz, R. Klein, et al. 2002. Risk factors for type II diabetes and diabetic retinopathy in a Mexican-American population; Proyecto VER. Am J Ophthalmol. 134: 390–398.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Wilson, M.R., Gallardo, M. (2010). Glaucoma Risk Factors: Ethnicity and Glaucoma. In: Schacknow, P., Samples, J. (eds) The Glaucoma Book. Springer, New York, NY. https://doi.org/10.1007/978-0-387-76700-0_10

Download citation

  • DOI: https://doi.org/10.1007/978-0-387-76700-0_10

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-76699-7

  • Online ISBN: 978-0-387-76700-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics