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Pancreas Biology, Pathology, and Tissue Engineering

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Strategies in Regenerative Medicine

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Authors and Affiliations

  1. School of Pharmacy & Biomolecular Sciences, University of Brighton, Cockcroft Building Lewes Road, Brighton BN2 4GJ, UK

    Wendy M. MacFarlane

Authors
  1. Wendy M. MacFarlane
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  2. Adrian J. Bone
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  3. Moira Harrison
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Corresponding author

Correspondence to Wendy M. MacFarlane .

Editor information

Editors and Affiliations

  1. School of Pharmacy &, Biomolecular Sciences, University of Brighton, Lewes Road, Brighton, BN2 4GJ, United Kingdom

    Matteo Santin

Additional information

Questions/Exercises

  1. 1.

    Describe the cell mechanisms leading to T1D.

  2. 2.

    Highlight the molecular mechanisms underpinning T2D and its possible links with T1D.

  3. 3.

    Describe the main histological features of the pancreas and their pathological alteration following T1D insurgence.

  4. 4.

    Highlight the main biochemical and cellular prerequisites in pancreas tissue engineering.

  5. 5.

    Present the main clinical procedure for pancreatic islet transplantation and alternative suggested protocols; a critical discussion of their advantages and disadvantages.

  6. 6.

    List the factors leading to β cell apoptosis following pancreatic islet transplantation and explore the main strategies adopted to prevent it.

  7. 7.

    Speculate on the physico-chemical and biocompatibility properties of an ideal biomaterial scaffold for pancreas tissue engineering.

  8. 8.

    Analyze the molecular and cell biology links between diabetes and other pathologies such as cardiovascular diseases.

  9. 9.

    Discuss in a critical manner the main protocols used for in vitro pancreatic islet regeneration.

  10. 10.

    Analyze the current limitations in using embryonic stem cells for pancreatic islet regeneration and indicate the future perspectives.

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MacFarlane, W.M., Bone, A.J., Harrison, M. (2009). Pancreas Biology, Pathology, and Tissue Engineering. In: Santin, M. (eds) Strategies in Regenerative Medicine. Springer, New York, NY. https://doi.org/10.1007/978-0-387-74660-9_8

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