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Clinical Approaches to Skin Regeneration

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Strategies in Regenerative Medicine

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Acknowledgments

SEJ would like to thank the surgeons at the Queen Victoria Hospital, East Grinstead, UK for exposing this scientist to the world of surgery and opening up invaluable communications between scientists and surgeons. Special thanks to Nick Parkhouse; Phil Gilbert; Balj Dheansa; Tania Cubison; John Boorman; Sheraz Daya and Ken Lavery, all of whom have contributed directly or indirectly to this work.

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Authors and Affiliations

  1. School of Pharmacy and Biomolecular Sciences, University of Brighton, , Sussex, UK

    S. E. James

Authors
  1. S. E. James
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  2. S. Booth
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  3. P. Gilbert
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  4. I. Jones
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  5. R. Shevchenko
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Corresponding author

Correspondence to S. E. James .

Editor information

Editors and Affiliations

  1. School of Pharmacy &, Biomolecular Sciences, University of Brighton, Lewes Road, Brighton, BN2 4GJ, United Kingdom

    Matteo Santin

Additional information

Questions/Exercises

  1. 1.

    What are the main histological features of the dermis and their functions?

  2. 2.

    Describe the histological features characterizing the different depths of burn injury.

  3. 3.

    Present the biochemical and cellular basis leading to hypertrophic scarring.

  4. 4.

    Discuss the main pathological conditions leading to death in burned patients.

  5. 5.

    Critically assess the clinical performance and commercial viability of three typical dermal substitutes and highlight their common and distinct features.

  6. 6.

    Develop a comparative analysis between the clinical use and performance of acellular and cellular dermal substitutes.

  7. 7.

    Illustrate the split skin graft technique and highlight its advantages and limitations

  8. 8.

    Highlight the advances in, and limitations of, the in vitro skin cell expansion technique.

  9. 9.

    Explore the research and clinical outcome of autologous cell spray when applied with dermal substitutes.

  10. 10.

    Provide examples of neglected biomaterials which may lead to the manufacturing of highly performing dermal substitutes.

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James, S.E., Booth, S., Gilbert, P., Jones, I., Shevchenko, R. (2009). Clinical Approaches to Skin Regeneration. In: Santin, M. (eds) Strategies in Regenerative Medicine. Springer, New York, NY. https://doi.org/10.1007/978-0-387-74660-9_5

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