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A Mathematical Model of pHi Regulation in Central CO2 - Chemoreception

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Integration in Respiratory Control

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 605))

In CO2 chemosensitive neurons, an increase in CO2 (hypercapnia) leads to a maintained reduction in intracellular pH (pHi) while in non-chemosensitive neurons pHi recovery is observed. The precise mechanisms for the differential regulation of pHi recovery between these cell populations remain to be identified; however, studies have begun to explore the role of Na+/H+ exchange (NHE). Here, we compare the results of two different formulations of a mathematical model to begin to explore pHi regulation in central CO2 chemoreception.

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References

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Authors
  1. Juan M. Cordovez
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  2. Chris Clausen
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  3. Leon C. Moore
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  4. Irene C. Solomon
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Editor information

Editors and Affiliations

  1. University of Calgary, 3330 Hospital Drive NW, Calgary, T2N 4N1, Canada

    Marc J. Poulin  & Richard J. A. Wilson  & 

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Cordovez, J.M., Clausen, C., Moore, L.C., Solomon, I.C. (2008). A Mathematical Model of pHi Regulation in Central CO2 - Chemoreception. In: Poulin, M.J., Wilson, R.J.A. (eds) Integration in Respiratory Control. Advances in Experimental Medicine and Biology, vol 605. Springer, New York, NY. https://doi.org/10.1007/978-0-387-73693-8_53

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