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Fc Receptors for IgA

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Mucosal Immune Defense: Immunoglobulin A

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Immunoglobulin A (IgA) is, by far, the most abundant immunoglobulin produced in humans and is also the most heterogeneous (Kerr, 1990; Woof and Mestecky, 2005) (see Chapter 1). Human serum IgA, produced by plasma cells in the bone marrow, lymph nodes, and spleen, is mainly monomeric (mIgA) and constitutes ~15–20%of the total serum Ig pool. However, IgA predominates at the mucosa, as 80–90%of mucosal plasma cells produce this isotype (Brandtzaeg et al., 1999). In addition to IgA, mucosal plasma cells also express a small polypeptide called the joining chain (J-chain) that directs the assembly of dimers and larger polymers [collectively called polymeric IgA (pIgA)] (Johansen et al., 2000).

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  1. Institute of Marine Research, 5817, Bergen, Norway

    H. Craig Morton

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  1. University of Kentucky, 40536, Lexington, KY, USA

    Charlotte Slayton Kaetzel

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Morton, H.C. (2007). Fc Receptors for IgA. In: Kaetzel, C.S. (eds) Mucosal Immune Defense: Immunoglobulin A. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-72232-0_4

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