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Pericytes, the Mural Cells of the Microvascular System

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Book cover Angiogenesis

Endothelial cells and pericytes regulate blood vessel formation, maturation and specification, all of which requires the orchestration of tightly regulated molecules. Communication between these two distinct vascular cell types occurs by direct cell contact and by paracrine signaling pathways. Pericytes and endotheslial cells are interdependent and defects in either can affect the vascular system. Loss of pericytes can lead to hyperdilated and hemorrhagic blood vessels, which lead to conditions such as edema, diabetic retinopathy, and even embryonic lethality. In tumors, although pericytes are less abundant and more loosely attached, pericyte dysfunction can result in increased endothelial cell apoptosis and metastatic spread, providing evidence that tumor pericytes are implicated in vessel maintenance, endothelial cell survival and potentially tumor dormancy. Based on their functional importance, pericytes present a complimentary target to endothelial cells in tumors. Therefore, combinatorial targeting of both cell types might have the potential to more efficiently diminish tumor vessels and halt subsequent tumor growth.

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Authors and Affiliations

  1. Department of Neurological Surgery, University of California, 94143, San Francisco, CA, USA

    Gabriele Bergers

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  1. Gabriele Bergers
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Editors and Affiliations

  1. Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA

    William D. Figg

  2. Department of Surgery Harvard Medical School and Vascular Biology Program, Children's Hospital Boston, Boston, MA, USA

    Judah Folkman

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Bergers, G. (2008). Pericytes, the Mural Cells of the Microvascular System. In: Figg, W.D., Folkman, J. (eds) Angiogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-71518-6_4

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  • DOI: https://doi.org/10.1007/978-0-387-71518-6_4

  • Publisher Name: Springer, Boston, MA

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