Skip to main content

Mediastinum

  • Chapter
Surgery
  • 302 Accesses

Abstract

The term mediastinum refers to the region of the body located between the two pleural spaces. It is derived from the Latin words medius (middle) and stare (to stand) and means literally “standing in the middle” Although this definition is anatomically descriptive, it belies the fact that the mediastinum is a complex and tightly knit package of structures immediately vital to the life of the individual—the central airways, the heart, and the great vessels. Also contained within the mediastinum are myriad other tissues, glands, and organs, including the esophagus, thymus, thoracic duct, vagus and phrenic nerves, and lymphatics. The mediastinum extends from the diaphragm to the thoracic inlet and is divided by anatomists into four regions that are defined by their relationship to the pericardium: superior, anterior, middle, and posterior. In this scheme, the middle compartment is equivalent to the pericardial sac and its contents. In contrast, as is discussed in more detail later in this chapter, thoracic surgeons generally divide the mediastinum into just three compartments: anterior, middle, and posterior. In this scheme, the anatomists’ superior compartment is divided between the anterior and middle compartments, and the esophagus is included in the middle rather than posterior compartment.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 219.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Pearse HE. Mediastinitis following cervical suppuration. Ann Surg 1938;108:588–611.

    Article  PubMed  CAS  Google Scholar 

  2. Estrera AS, Landay MJ, Grisham JM, et al. Descending necrotizing mediastinitis. Surg Gynecol Obstet 1983;157:545–552.

    PubMed  CAS  Google Scholar 

  3. Wheatley MJ, Stirling MC, Kirsh MM, et al. Descending necrotizing mediastinitis: transcervical drainage is not enough. Ann Thorac Surg 1990;49:780–784.

    PubMed  CAS  Google Scholar 

  4. Corsten MJ, Shamji FM, Odell PF, et al. Optimal treatment of descending necrotising mediastinitis. Thorax 1997;52:702–708.

    Article  PubMed  CAS  Google Scholar 

  5. Freeman RK, Vallieres E, Verrier ED, et al. Descending necrotizing mediastinitis: an analysis of the effects of serial surgical debridement on patient mortality. J Thorac Cardiovasc Surg 2000;119:260–267.

    Article  PubMed  CAS  Google Scholar 

  6. Marty-Ane CH, Alauzen M, Alric P, et al. Descending necrotizing mediastinitis. Advantage of mediastinal drainage with thoracotomy. J Thorac Cardiovasc Surg 1994;107:55–61.

    PubMed  CAS  Google Scholar 

  7. Moncada R, Warpeha R, Pickleman J, et al. Mediastinitis from odontogenic and deep cervical infection. Anatomic pathways of propagation. Chest 1978;73:497–500.

    Article  PubMed  CAS  Google Scholar 

  8. Kiernan PD, Hernandez A, Byrne WD, et al. Descending cervical mediastinitis. Ann Thorac Surg 1998;65:1483–1488.

    Article  PubMed  CAS  Google Scholar 

  9. Blomquist IK, Bayer AS. Life-threatening deep fascial space infections of the head and neck. Infect Dis Clin North Am 1988;2:237–264.

    PubMed  CAS  Google Scholar 

  10. Chow AW. Life-threatening infections of the head and neck. Clin Infect Dis 1992;14:991–1002.

    PubMed  CAS  Google Scholar 

  11. Roberts JR, Smythe WR, Weber RW, et al Thoracoscopic management of descending necrotizing mediastinitis. Chest 1997;112:850–854.

    Article  PubMed  CAS  Google Scholar 

  12. Laisaar T. Video-assisted thoracoscopic surgery in the management of acute purulent mediastinitis and pleural empyema. Thorac Cardiovasc Surg 1998;46:51–54.

    Article  PubMed  CAS  Google Scholar 

  13. Hang LW, Lien TC, Wang LS, et al. Hyperbaric oxygen as an adjunctive treatment for descending necrotizing mediastinitis: a case report. Chung Hua I Hsueh Tsa Chih 1997;60:52–56.

    PubMed  CAS  Google Scholar 

  14. Milton H. Mediastinal surgery. Lancet 1897;1:872–875.

    Article  Google Scholar 

  15. Gibbon JH. Application of a mechanical heart and lung apparatus to cardiac surgery. Minn Med 1954;37:171.

    PubMed  Google Scholar 

  16. Loop FD, Lytle BW, Cosgrove DM, et al. J. Maxwell Chamberlain Memorial Paper. Sternal wound complications after isolated coronary artery bypass grafting: early and late mortality, morbidity, and cost of care. Ann Thorac Surg 1990;49:179–186; discussion 186–187.

    PubMed  CAS  Google Scholar 

  17. Milano CA, Kesler K, Archibald N, et al. Mediastinitis after coronary artery bypass graft surgery. Risk factors and long-term survival. Circulation 1995;92:2245–2251.

    PubMed  CAS  Google Scholar 

  18. Farinas MC, Gald Peralta F, Bernal JM, et al. Suppurative mediastinitis after open-heart surgery: a case-control study covering a 7-year period in Santander, Spain. Clin Infect Dis 1995;20:272–279.

    PubMed  CAS  Google Scholar 

  19. El Oakley R, Paul E, Wong PS, et al. Mediastinitis in patients undergoing cardiopulmonary bypass: risk analysis and midterm results. J Cardiovasc Surg 1997;38:595–600.

    Google Scholar 

  20. Braxton JH, Marrin CA, McGrath PD, et al. Northern New England Cardiovascular Disease Study Group. Mediastinitis and long-term survival after coronary artery bypass graft surgery. Ann Thorac Surg 2000;70:2004–2007.

    Article  PubMed  CAS  Google Scholar 

  21. Taylor GJ, Mikell FL, Moses HW, et al. Determinants of hospital charges for coronary artery bypass surgery: the economic consequences of postoperative complications. Am J Cardiol 1990;65:309–313.

    Article  PubMed  CAS  Google Scholar 

  22. Abid Q, Nkere UU, Hasan A, et al. Mediastinitis in heart and lung transplantation: 15 years experience. Ann Thorac Surg 2003;75:1565–1571.

    Article  PubMed  Google Scholar 

  23. Baldwin RT, Radovancevic B, Sweeney MS, et al. Bacterial mediastinitis after heart transplantation. J Heart Lung Transplant 1992;11:545–549.

    PubMed  CAS  Google Scholar 

  24. Breatnach E, Nath PH, Delany DJ. The role of computed tomography in acute and subacute mediastinitis. Clin Radiol 1986;37:139–145.

    Article  PubMed  CAS  Google Scholar 

  25. Misawa Y, Fuse K, Hasegawa T. Infectious mediastinitis after cardiac operations: computed tomographic findings. Ann Thorac Surg 1998;65:622–624.

    Article  PubMed  CAS  Google Scholar 

  26. Jolles H, Henry DA, Roberson JP, et al. Mediastinitis following median sternotomy: CT findings. Radiology 1996;201:463–466.

    PubMed  CAS  Google Scholar 

  27. Browdie DA, Bernstein RV, Agnew R, et al. Diagnosis of poststernotomy infection: comparison of three means of assessment. Ann Thorac Surg 1991;51(2):290–292.

    Article  PubMed  CAS  Google Scholar 

  28. Bitkover CY, Gardlund B, Larsson SA, et al. Diagnosing sternal wound infections with 99mTc-labeled monoclonal granulocyte antibody scintigraphy. Ann Thorac Surg 1996;62:1412–1416;discussion 1416–1417.

    Article  PubMed  CAS  Google Scholar 

  29. Ferrazzi P, Allen R, Crupi G, et al. Reduction of infection after cardiac surgery: a clinical trial. Ann Thorac Surg 1986;42:321–325.

    PubMed  CAS  Google Scholar 

  30. Ehrenkranz NJ, Pfaff SJ. Mediastinitis complicating cardiac operations: evidence of postoperative causation. Rev Infect Dis 1991;13:803–814.

    PubMed  CAS  Google Scholar 

  31. Bitkover CY, Gardlund B. Mediastinitis after cardiovascular operations: a case-control study of risk factors. Ann Thorac Surg 1998;65:36–40.

    Article  PubMed  CAS  Google Scholar 

  32. Munoz P, Menasalvas A, Bernaldo de Quiros JC, et al. Postsurgical mediastinitis: a case-control study. Clin Infect Dis 1997;25:1060–1064.

    Article  PubMed  CAS  Google Scholar 

  33. Grover FL, Johnson RR, Marshall G, et al. Impact of mammary grafts on coronary bypass operative mortality and morbidity. Department of Veterans Affairs Cardiac Surgeons. Ann Thorac Surg 1994;57:559–568; discussion 568–569.

    Article  PubMed  CAS  Google Scholar 

  34. Lu JC, Grayson AD, Jha P, et al. Risk factors for sternal wound infection and mid-term survival following coronary artery bypass surgery. Eur J Cardiothorac Surg 2003;23:943–949.

    Article  PubMed  Google Scholar 

  35. Lust RM, Sun YS, Chitwood WR Jr. Internal mammary artery use. Sternal revascularization and experimental infection patterns. Circulation 1991;84:111285–111289.

    Google Scholar 

  36. Risk factors for deep sternal wound infection after sternotomy: a prospective, multicenter study [see comments]. J Thorac Cardiovasc Surg 1996;111:1200–1207.

    Google Scholar 

  37. Morykwas MJ, Argenta LC, Shelton-Brown EI, et al. Vacuum-assisted closure: a new method for wound control and treatment: animal studies and basic foundation. Ann Plast Surg 1997;38:553–562.

    Article  PubMed  CAS  Google Scholar 

  38. Song DH, Wu LC, Lohman RF, et al. Vacuum assisted closure for the treatment of sternal wounds: the bridge between debridement and definitive closure. Plast Reconstr Surg 2003;111:92–97.

    Article  PubMed  Google Scholar 

  39. Berg HF, Brands WG, van Geldorp TR, et al. Comparison between closed drainage techniques for the treatment of postoperative mediastinitis. Ann Thorac Surg 2000;70:924–929.

    Article  PubMed  CAS  Google Scholar 

  40. El Gamel A, Yonan NA, Hassan R, et al. Treatment of mediastinitis: early modified Robicsek closure and pectoralis major advancement flaps [see comments]. Ann Thorac Surg 1998;65:41–64; discussion 46–47.

    Article  PubMed  Google Scholar 

  41. Lopez-Monjardin H, de-la-Pena-Salcedo A, Mendoza-Munoz M, et al. Omentum flap versus pectoralis major flap in the treatment of mediastinitis. Plast Reconstr Surg 1998;101:1481–1485.

    Article  PubMed  CAS  Google Scholar 

  42. Jones G, Jurkiewicz MJ, Bostwick J, et al. Management of the infected median sternotomy wound with muscle flaps. The Emory 20-year experience. Ann Surg 1997;225:766–776; discussion 776–778.

    Article  PubMed  CAS  Google Scholar 

  43. Szerafin T, Vaszily M, Peterffy A. Granulated sugar treatment of severe mediastinitis after open-heart surgery. Scand J Thorac Cardiovasc Surg 1991;25:77–80.

    PubMed  CAS  Google Scholar 

  44. Kustal A, Ibrisim E, Catav Z, et al. Mediastinitis after open heart surgery. Analysis of risk factors and management. J Cardiovasc Surg 1991;32:38–41.

    Google Scholar 

  45. Domkowski PW, Smith ML, Gonyon DL Jr, et al. Evaluation of vacuum-assisted closure in the treatment of poststernotomy mediastinitis. J Thorac Cardiovasc Surg 2003;126:386–390.

    Article  PubMed  Google Scholar 

  46. Ringelman PR, Vander Kolk CA, Cameron D, et al. Long-term results of flap reconstruction in median sternotomy wound infections. Plast Reconstr Surg 1994;93:1208–1214; discussion 1215–1216.

    Article  PubMed  CAS  Google Scholar 

  47. Scully HE, Leclerc Y, Martin RD, et al. Comparison between antibiotic irrigation and mobilization of pectoral muscle flaps in treatment of deep sternal infections. J Thorac Cardiovasc Surg 1985;90:523–531.

    PubMed  CAS  Google Scholar 

  48. Oulmont N. Des Obliterations de la Veine Cava Superieure. Paris: Bailliere; 1855.

    Google Scholar 

  49. Osier W. On obliteration of the superior vena cava. Bull Johns Hopkins Hosp 1903;14:169–182.

    Google Scholar 

  50. Knox LB. Chronic mediastinitis. Am J Med Sci 1925;169:807–820.

    Article  Google Scholar 

  51. Mole TM, Glover J, Sheppard MN. Sclerosing mediastinitis: a report on 18 cases. Thorax 1995;50:280–283.

    Article  PubMed  CAS  Google Scholar 

  52. Sherrick AD, Brown LR, Harms GF, et al. The radiographic findings of fibrosing mediastinitis. Chest 1994;106:484–489.

    Article  PubMed  CAS  Google Scholar 

  53. Urschel HC Jr, Razzuk MA, Netto GJ, et al. Sclerosing mediastinitis: improved management with histoplasmosis titer and ketoconazole. Ann Thorac Surg 1990;50:215–221.

    Article  PubMed  Google Scholar 

  54. Dines DE, Payne WS, Bernatz PE, et al. Mediastinal granuloma and fibrosing mediastinitis. Chest 1979;75:320–324.

    Article  PubMed  CAS  Google Scholar 

  55. Dunn EJ, Ulicny KS, Wright CB, et al. Surgical implications of sclerosing mediastinitis: a report of six cases and review of the literature. Chest 1990;97:338–346.

    Article  PubMed  CAS  Google Scholar 

  56. Lagerstrom CF, Mitchell HG, Graham BS, et al. Chronic fibrosing mediastinitis and superior vena caval obstruction from blastomycosis. Ann Thorac Surg 1992;54:764–765.

    Article  PubMed  CAS  Google Scholar 

  57. Graham JR, Suby HI, LeCompte PR, et al. Fibrotic disorders associated with methysergide therapy for headache. N Engl J Med 1966;274:359–368.

    Article  PubMed  CAS  Google Scholar 

  58. Goodwin RA, Nickell JA, Des Prez RM. Mediastinal fibrosis complicating healed primary histoplasmosis and tuberculosis. Medicine (Baltimore) 1972;51:227–246.

    Article  PubMed  CAS  Google Scholar 

  59. Rabinowitz JG, Prater W, Silver J, et al. Mediastinal histoplasmosis. Mt Sinai J Med 1980;47:356–363.

    PubMed  CAS  Google Scholar 

  60. Rholl KS, Levitt RG, Glazer HS. Magnetic resonance imaging of fibrosing mediastinitis. AJR Am J Roentgenol 1985;145:255–259.

    PubMed  CAS  Google Scholar 

  61. Mathisen DJ, Grillo HC. Clinical manifestation of mediastinal fibrosis and histoplasmosis. Ann Thorac Surg 1992;54:1053–1057; discussion 1057–1058.

    Article  PubMed  CAS  Google Scholar 

  62. Hunter W. The history of an aneurysm of the aorta with some remarks on aneurysms in general. Med Obs Soc Phys Lond 1757;1:323.

    Google Scholar 

  63. Nieto AF, Doty DB. Superior vena cava obstruction: clinical syndrome, etiology, and treatment. Curr Probl Cancer 1986;10:441–484.

    Article  PubMed  CAS  Google Scholar 

  64. Ahmann FR. A reassessment of the clinical implications of the superior vena caval syndrome. J Clin Oncol 1984;2:961–969.

    PubMed  CAS  Google Scholar 

  65. Escalante CP. Causes and management of superior vena cava syndrome. Oncology 1993;7:61–68; discussion 71–72, 75–77.

    PubMed  CAS  Google Scholar 

  66. Wurschmidt F, Bunemann H, Heilmann HP. Small cell lung cancer with and without superior vena cava syndrome: a multivariate analysis of prognostic factors in 408 cases. Int J Radiat Oncol Biol Phys 1995;33:77–82.

    PubMed  CAS  Google Scholar 

  67. Goudevenos JA, Reid PG, Adams PC, et al. Pacemaker-induced superior vena cava syndrome: report of four cases and review of the literature. Pacing Clin Electrophysiol 1989;12:1890–1895.

    Article  PubMed  CAS  Google Scholar 

  68. Mazzetti H, Dussaut A, Tentori C, et al. Superior vena cava occlusion and/or syndrome related to pacemaker leads. Am Heart J 1993;125:831–837.

    Article  PubMed  CAS  Google Scholar 

  69. Kee ST, Kinoshita L, Razavi MK, et al. Superior vena cava syndrome: treatment with catheter-directed thrombolysis and endovascular stent placement. Radiology 1998;206:187–193.

    PubMed  CAS  Google Scholar 

  70. Chan RH, Dar AR, Yu E, et al. Superior vena cava obstruction in small-cell lung cancer. Int J Radiat Oncol Biol Phys 1997;38:513–520.

    PubMed  CAS  Google Scholar 

  71. Doty JR, Flores JH, Doty DB. Superior vena cava obstruction: bypass using spiral vein graft. Ann Thorac Surg 1999;67:1111–1116.

    Article  PubMed  CAS  Google Scholar 

  72. Ohri SK, Lawrence DR, Townsend ER. Homograft as a conduit for superior vena cava syndrome [see comments]. Ann Thorac Surg 1997;64:531–533.

    Article  PubMed  CAS  Google Scholar 

  73. Seelig MH, Oldenburg WA, Klingler PJ, et al. Superior vena cava syndrome caused by chronic hemodialysis catheters: autologous reconstruction with a pericardial tube graft. J Vasc Surg 1998;28:556–560.

    Article  PubMed  CAS  Google Scholar 

  74. Graham A, Anikin V, Curry R, et al. Subcutaneous jugulofemoral bypass: a simple surgical option for palliation of superior vena cava obstruction. J Cardiovasc Surg 1995;36:615–617.

    CAS  Google Scholar 

  75. Alimi YS, Gloviczki P, Vrtiska TJ, et al. Reconstruction of the superior vena cava: benefits of postoperative surveillance and secondary endovascular interventions. J Vasc Surg 1998;27:287–299;300–301.

    Article  PubMed  CAS  Google Scholar 

  76. Hochrein J, Bashore TM, O’Laughlin MP, et al. Percutaneous stenting of superior vena cava syndrome: a case report and review of the literature. Am J Med 1998;104:78–84.

    Article  PubMed  CAS  Google Scholar 

  77. Davis RW, Oldham HN, Sabiston DC. The mediastinum. In: Sabiston DC, Spencer FC, eds. Surgery of the Chest, Vol. 1. Philadelphia: Saunders; 1995:576–612.

    Google Scholar 

  78. Shields TW. Primary lesions of the mediastinum and their investigation and treatment. In: Shields TW, ed. General Thoracic Surgery, Vol. 2. Malvern, PA: Williams and Wilkins; 1994;1724–1769.

    Google Scholar 

  79. Davis RD Jr, Oldham HN Jr, Sabiston DC Jr. Primary cysts and neoplasms of the mediastinum: recent changes in clinical presentation, methods of diagnosis, management, and results. Ann Thorac Surg 1987;44:229–237.

    Article  PubMed  Google Scholar 

  80. Azarow KS, Pearl RH, Zurcher R, et al. Primary mediastinal masses. A comparison of adult and pediatric populations. J Thorac Cardiovasc Surg 1993;106:67–72.

    PubMed  CAS  Google Scholar 

  81. Massie RJ, Van Asperen PP, Mellis CM. A review of open biopsy for mediastinal masses. J Paediatr Child Health 1997;33:230–233.

    Article  PubMed  CAS  Google Scholar 

  82. Whooley BP, Urschel JD, Antkowiak JG, et al. Primary tumors of the mediastinum. J Surg Oncol 1999;70:95–99.

    Article  PubMed  CAS  Google Scholar 

  83. Nobuhara KK, Gorski YC, La Quaglia MP, et al. Bronchogenic cysts and esophageal duplications: common origins and treatment. J Pediatr Surg 1997;32:1408–1413.

    Article  PubMed  CAS  Google Scholar 

  84. Hunerbein M, Ghadimi BM, Haensch W, et al. Transesophageal biopsy of mediastinal and pulmonary tumors by means of endoscopic ultrasound guidance. J Thorac Cardiovasc Surg 1998;116:554–559.

    Article  PubMed  CAS  Google Scholar 

  85. Powers CN, Silverman JF, Geisinger KR, et al. Fine-needle aspiration biopsy of the mediastinum. A multi-institutional analysis. Am J Clin Pathol 1996;105:168–173.

    PubMed  CAS  Google Scholar 

  86. Singh HK, Silverman JF, Powers CN, et al. Diagnostic pitfalls in fine-needle aspiration biopsy of the mediastinum. Diagn Cytopathol 1997;17:121–126.

    Article  PubMed  CAS  Google Scholar 

  87. Shabb NS, Fahl M, Shabb B, et al. Fine-needle aspiration of the mediastinum: a clinical, radiologic, cytologic, and histologic study of 42 cases. Diagn Cytopathol 1998;19:428–436.

    Article  PubMed  CAS  Google Scholar 

  88. Gossot D, Toledo L, Fritsch S, et al. Mediastinoscopy versus thoracoscopy for mediastinal biopsy. Results of a prospective nonrandomized study. Chest 1996;110:1328–1331.

    Article  PubMed  CAS  Google Scholar 

  89. Blumberg D, Port JL, Weksler B, et al. Thymoma: a multivariate analysis of factors predicting survival. Ann Thorac Surg 1995;60:908–913;discussion 914.

    Article  PubMed  CAS  Google Scholar 

  90. Newman E, Shaha AR. Substernal goiter. J Surg Oncol 1995;60:207–212.

    Article  PubMed  CAS  Google Scholar 

  91. Moron JC, Singer JA, Sardi A. Retrosternal goiter: a 6-year institutional review. Am Surg 1998;64:889–893.

    PubMed  CAS  Google Scholar 

  92. Katlic MR, Grillo HC, Wang CA. Substernal goiter. Analysis of 80 patients from Massachusetts General Hospital. Am J Surg 1985;149:283–287.

    Article  PubMed  CAS  Google Scholar 

  93. Sanders LE, Rossi RL, Shahian DM, et al. Mediastinal goiters. The need for an aggressive approach. Arch Surg 1992;127:609–613.

    PubMed  CAS  Google Scholar 

  94. Moran CA, Suster S, Fishback N, et al. Extramedullar hematopoiesis presenting as posterior mediastinal mass: a study of four cases. Mod Pathol 1995;8:249–251.

    PubMed  CAS  Google Scholar 

  95. Gentry SE, Harris MA. Posterior mediastinal mass in a patient with chest pain. Chest 1995;107:1757–1759.

    Article  PubMed  CAS  Google Scholar 

  96. Akwari OE, Payne WS, Onofrio BM, et al. Dumbbell neurogenic tumors of the mediastinum. Diagnosis and management. Mayo Clin Proc 1978;53:353–358.

    PubMed  CAS  Google Scholar 

  97. Grillo HC, Ojemann RG, Scannell JG, et al. Combined approach to “dumbbell” intrathoracic and intraspinal neurogenic tumors. Ann Thorac Surg 1983;36:402–407.

    Article  PubMed  CAS  Google Scholar 

  98. Guglielmi M, De Bernardi B, Rizzo A, et al. Resection of primary tumor at diagnosis in stage IV-S neuroblastoma: does it affect the clinical course? J Clin Oncol 1996;14:1537–1544.

    PubMed  CAS  Google Scholar 

  99. Martinez DA, King DR, Ginn-Pease ME, et al. Resection of the primary tumor is appropriate for children with stage IV-S neuroblastoma: an analysis of 37 patients. J Pediatr Surg 1992;27:1016–1020; discussion 1020–1021.

    Article  PubMed  CAS  Google Scholar 

  100. Aoyama C, Qualman SJ, Reagan M, et al. Histopathologic features of composite ganglioneuroblastoma. Immunohistochemical distinction of the stromal component is related to prognosis. Cancer (St. Louis) 1990;65:255–264.

    Article  PubMed  CAS  Google Scholar 

  101. Guidetti D, Sabadini R, Bondavalli M, et al. Epidemiological study of myasthenia gravis in the province of Reggio Emilia, Italy. Eur J Epidemiol 1998;14:381–387.

    Article  PubMed  CAS  Google Scholar 

  102. Robertson NP, Deans J, Compston DA. Myasthenia gravis: a population-based epidemiological study in Cambridgeshire, England. J Neurol Neurosurg Psychiatry 1998;65:492–496.

    Article  PubMed  CAS  Google Scholar 

  103. Osserman KE, Genkins G. Studies in myasthenia gravis: review of a 20-year experience in over 1200 patients. Mt Sinai J Med 1971;38:497–537.

    PubMed  CAS  Google Scholar 

  104. Papatestas AE, Genkins G, Kornfeld P, et al. Effects of thymectomy in myasthenia gravis. Ann Surg 1987;206:79–88.

    Article  PubMed  CAS  Google Scholar 

  105. Cosi V, Romani A, Lombardi M, et al. Prognosis of myasthenia gravis: a retrospective study of 380 patients. J Neurol 1997;244:548–555.

    Article  PubMed  CAS  Google Scholar 

  106. Beekman R, Kuks JB, Oosterhuis HJ. Myasthenia gravis: diagnosis and follow-up of 100 consecutive patients. J Neurol 1997;244:112–118.

    Article  PubMed  CAS  Google Scholar 

  107. Walker MB. Treatment of myasthenia gravis with physostig-mine. Lancet 1934;1:1200–1201.

    Article  Google Scholar 

  108. Osserman KE, Teng P, Kaplan LI. Studies in myasthenia gravis: preliminary report on therapy with mestinon bromide. JAMA 1954;155:961.

    CAS  Google Scholar 

  109. Hoppe HH. Ein beitrag zur Kenntnis der bulbarparalyse. Berl Klin Wochenschr 1892;29:332–336.

    Google Scholar 

  110. Weigert C. Pathologisch-anatomischer beitrag zur erb’schen krankheit (myasthenia gravis). Neurol Centralbl 1901;13:597.

    Google Scholar 

  111. Sauerbruch DR, Roth D. Thymektomie bei einem Fall von Marbus Basedowi mit Myasthenie. Mitt Grenzgeb Med Chir 1913;25:746–765.

    Google Scholar 

  112. von Haberer A. Zur klinischen Bedeutung der Thymus Druse. Arch Klin Chir 1917;109:193.

    Google Scholar 

  113. Bell ET. Tumors of the thymus in myasthenia gravis. J Nerv Ment Dis 1917;45:130–143.

    Article  Google Scholar 

  114. Blalock A, Mason MF, Morgan HF, et al. Myasthenia gravis and tumors of the thymic region: report of a case in which the tumor was removed. Ann Surg 1939;110:544–561.

    Article  PubMed  CAS  Google Scholar 

  115. Blalock A. Thymectomy in the treatment of mysthenia gravis: report of 20 cases. J Thorac Cardiovasc Surg 1944;13:316.

    Google Scholar 

  116. Damjanovic M, Vidic-Dankovic B, Kosec D, et al. Thymus changes in experimentally induced myasthenia gravis. Autoimmunity 1993;15:201–207.

    Article  PubMed  CAS  Google Scholar 

  117. Spuler S, Marx A, Kirchner T, et al. Myogenesis in thymic transplants in the severe combined immunodeficient mouse model of myasthenia gravis. Differentiation of thymic myoid cells into striated muscle cells. Am J Pathol 1994;145:766–770.

    PubMed  CAS  Google Scholar 

  118. Moran CA, Suster S, Gil J, et al. Morphometric analysis of germinal centers in nonthymomatous patients with mysthenia gravis. Arch Pathol Lab Med 1990;114:689–691.

    PubMed  CAS  Google Scholar 

  119. Buckingham JM, Howard FM Jr, Bernatz PE, et al. The value of thymectomy in myasthenia gravis: a computer-assisted matched study. Ann Surg 1976;184:453–458.

    Article  PubMed  CAS  Google Scholar 

  120. Mantegazza R, Baggi F, Antozzi C, et al. Myasthenia gravis (MG): epidemiological data and prognostic factors. Ann N Y Acad Sci 2003;998:413–423.

    Article  PubMed  Google Scholar 

  121. Jaretzki AD, Penn AS, Younger DS, et al. “Maximal“ thymectomy for myasthenia gravis. Results. J Thorac Cardiovasc Surg 1988;95:747–757.

    PubMed  Google Scholar 

  122. Cooper JD, Al-Jilaihawa AN, Pearson FG, et al. An improved technique to facilitate transcervical thymectomy for myasthenia gravis. Ann Thorac Surg 1988;45:242–247.

    Article  PubMed  CAS  Google Scholar 

  123. Glinjongol C, Paiboonpol S. Outcome after transsternal radical thymectomy for myasthenia gravis: 14-year review at Ratchaburi Hospital. J Med Assoc Thai 2004;87:1304–1310.

    PubMed  Google Scholar 

  124. Roth T, Ackermann R, Stein R, et al. Thirteen years follow-up after radical transsternal thymectomy for myasthenia gravis. Do short-term results predict long-term outcome? Eur J Cardiothorac Surg 2002;21:664–670.

    Article  PubMed  CAS  Google Scholar 

  125. Masaoka A, Yamakawa Y, Niwa H, et al. Extended thymectomy for myasthenia gravis patients: a 20-year review. Ann Thorac Surg 1996;62:853–859.

    Article  PubMed  CAS  Google Scholar 

  126. Frist WH, Thirumalai S, Doehring CB, et al. Thymectomy for the myasthenia gravis patient: factors influencing outcome. Ann Thorac Surg 1994;57:334–338.

    Article  PubMed  CAS  Google Scholar 

  127. Nussbaum MS, Rosenthal GJ, Samaha FJ, et al. Management of myasthenia gravis by extended thymectomy with anterior mediastinal dissection. Surgery (St. Louis) 1992;112:681–687; discussion 687–688.

    PubMed  CAS  Google Scholar 

  128. Mulder DG, Graves M, Herrmann C. Thymectomy for myasthenia gravis: recent observations and comparisons with past experience. Ann Thorac Surg 1989;48:551–555.

    Article  PubMed  CAS  Google Scholar 

  129. Shrager JB, Deeb ME, Mick R, et al. Transcervical thymectomy for myasthenia gravis achieves results comparable to thymectomy by sternotomy. Ann Thorac Surg 2002;74:320–326; discussion 326–327.

    Article  PubMed  Google Scholar 

  130. Calhoun RF, Ritter JH, Guthrie TJ, et al. Results of transcervical thymectomy for myasthenia gravis in 100 consecutive patients. Ann Surg 1999;230:555–559; discussion 559–561.

    Article  PubMed  CAS  Google Scholar 

  131. Bril V, Kojic J, Use WK, et al. Long-term clinical outcome after transcervical thymectomy for myasthenia gravis. Ann Thorac Surg 1998;65:1520–1522.

    Article  PubMed  CAS  Google Scholar 

  132. DeFilippi VJ, Richman DP, Ferguson MK. Transcervical thymectomy for myasthenia gravis. Ann Thorac Surg 1994;57:194–197.

    Article  PubMed  CAS  Google Scholar 

  133. Savcenko M, Wendt GK, Prince SL, et al. Video-assisted thymectomy for myasthenia gravis: an update of a single institution experience. Eur J Cardiothorac Surg 2002;22:978–983.

    Article  PubMed  Google Scholar 

  134. Mineo TC, Pompeo E, Lerut TE, et al. Thoracoscopic thymectomy in autoimmune myasthesia: results of left-sided approach. Ann Thorac Surg 2000;69:1537–1541.

    Article  PubMed  CAS  Google Scholar 

  135. Zielinski M, Kuzdzal J, Szlubowski A, et al. Comparison of late results of basic transsternal and extended transsternal thymectomies in the treatment of myasthenia gravis. Ann Thorac Surg 2004;78:253–258.

    Article  PubMed  Google Scholar 

  136. Rosai J, Levine GD. Tumors of the thymus. In: Atlas of Tumor Pathology. Second Series, Fascicle 13. Washington, DC: Armed Forces Institute of Pathology; 1976:99.

    Google Scholar 

  137. Marino M, Muller-Hermelink HK. Thymoma and thymic carcinoma. Relation of thymoma epithelial cells to the cortical and medullary differentiation of thymus. Virchows Arch A Pathol Anat Histopathol 1985;407:119–149.

    Article  PubMed  CAS  Google Scholar 

  138. Rosai J, Sobin LH. Histological typing of tumours of the thymus. In: International Histological Classification of Tumours. 2nd ed. New York: Springer; 1999.

    Google Scholar 

  139. Cowen D, Richaud P, Mornex F, et al. Thymoma: results of a multicentric retrospective series of 149 non-metastatic irradiated patients and review of the literature. FNCLCC trialists. Federation Nationale des Centres de Lutte Contre le Cancer. Radiother Oncol 1995;34:9–16.

    Article  PubMed  CAS  Google Scholar 

  140. Regnard JF, Magdeleinat P, Dromer C, et al. Prognostic factors and long-term results after thymoma resection: a series of 307 patients. J Thorac Cardiovasc Surg 1996;112:376–384.

    Article  PubMed  CAS  Google Scholar 

  141. Venuta F, Rendina EA, Pescarmona EO, et al. Multimodality treatment of thymoma: a prospective study. Ann Thorac Surg 1997;64:1585–1591; discussion 1591–1592.

    Article  PubMed  CAS  Google Scholar 

  142. Gripp S, Hilgers K, Wurm R, et al. Thymoma: prognostic factors and treatment outcomes. Cancer (Phila) 1998;83:1495–1503.

    Article  PubMed  CAS  Google Scholar 

  143. Kondo K, Monden Y. Thymoma and myasthenia gravis: a clinical study of 1089 patients from Japan. Ann Thorac Surg 2005;79:219–224.

    Article  PubMed  Google Scholar 

  144. Masaoka A, Monden Y, Nakahara K, et al. Follow-up study of thymomas with special reference to their clinical stages. Cancer (Phila) 1981;48:2485–2492.

    Article  PubMed  CAS  Google Scholar 

  145. Okumura M, Ohta M, Tateyama H, et al. The World Health Organization histologic classification system reflects the oncologic behavior of thymoma: a clinical study of 273 patients. Cancer 2002;94:624–632.

    Article  PubMed  Google Scholar 

  146. Kim DJ, Yang WI, Choi SS, et al. Prognostic and clinical relevance of the World Health Organization schema for the classification of thymic epithelial tumors: a clinicopathologic study of 108 patients and literature review. Chest 2005;127:755–761.

    Article  PubMed  Google Scholar 

  147. Nakagawa K, Asamura H, Matsuno Y, et al. Thymoma: a clinicopathologic study based on the new World Health Organization classification. J Thorac Cardiovasc Surg 2003;126:1134–1140.

    Article  PubMed  Google Scholar 

  148. Yagi K, Hirata T, Fukuse T, et al. Surgical treatment for invasive thymoma, especially when the superior vena cava is invaded. Ann Thorac Surg 1996;61:521–524.

    Article  PubMed  CAS  Google Scholar 

  149. Kim ES, Putnam JB, Komaki R, et al. Phase II study of a multi-disciplinary approach with induction chemotherapy, followed by surgical resection, radiation therapy, and consolidation chemotherapy for unresectable malignant thymomas: final report. Lung Cancer 2004;44:369–379.

    Article  PubMed  Google Scholar 

  150. Shin DM, Walsh GL, Komaki R, et al. A multidisciplinary approach to therapy for unresectable malignant thymoma. Ann Intern Med 1998;129:100–104.

    PubMed  CAS  Google Scholar 

  151. Rea F, Sartori F, Loy M, et al. Chemotherapy and operation for invasive thymoma. J Thorac Cardiovasc Surg 1993;106:543–549.

    PubMed  CAS  Google Scholar 

  152. Loehrer PJ Sr, Wang W, Johnson DH, et al. Eastern Cooperative Oncology Group phase II trial. Octreotide alone or with prednisone in patients with advanced thymoma and thymic carcinoma: an Eastern Cooperative Oncology Group phase II trial [erratum in J Clin Oncol 2004,22:2261]. J Clin Oncol 2004;22:293–299.

    Article  PubMed  CAS  Google Scholar 

  153. Palmieri G, Montella L, Martignetti A, et al. Somatostatin analogs and prednisone in advanced refractory thymic tumors. Cancer 2002;94:1414–1420.

    Article  PubMed  CAS  Google Scholar 

  154. Loehrer PJ Sr, Jiroutek M, Aisner S, et al. Combined etoposide, ifosfamide, and cisplatin in the treatment of patients with advanced thymoma and thymic carcinoma: an intergroup trial. Cancer 2001;91:2010–2015.

    Article  PubMed  CAS  Google Scholar 

  155. Highley MS, Underhill CR, Parnis FX, et al. Treatment of invasive thymoma with single-agent ifosfamide. J Clin Oncol 1999;17:2737–2744.

    PubMed  CAS  Google Scholar 

  156. Loehrer PJ Sr, Chen M, Kim K, et al. Cisplatin, doxorubicin, and cyclophosphamide plus thoracic radiation therapy for limited-stage unresectable thymoma: an intergroup trial. J Clin Oncol 1997;15:3093–3099.

    PubMed  CAS  Google Scholar 

  157. Giaccone G, Ardizzoni A, Kirkpatrick A, et al. Cisplatin and etoposide combination chemotherapy for locally advanced or metastatic thymoma. A phase II study of the European Organization for Research and Treatment of Cancer Lung Cancer Cooperative Group. J Clin Oncol 1996;14:814–820.

    PubMed  CAS  Google Scholar 

  158. Loehrer PJ Sr, Kim K, Aisner SC, et al. Cisplatin plus doxorubicin plus cyclophosphamide in metastatic or recurrent thymoma: final results of an intergroup trial. The Eastern Cooperative Oncology Group, Southwest Oncology Group, and Southeastern Cancer Study Group. J Clin Oncol 1994;12:1164–1168.

    PubMed  Google Scholar 

  159. Blumberg D, Burt ME, Bains MS, et al. Thymic carcinoma: current staging does not predict prognosis. J Thorac Cardiovasc Surg 1998;115:303–308; discussion 308–309.

    Article  PubMed  CAS  Google Scholar 

  160. Suster S, Moran CA. Thymic carcinoma: spectrum of differentiation and histologic types. Pathology 1998;30:111–122.

    Article  PubMed  CAS  Google Scholar 

  161. Quagliano PV. Thymic carcinoma: case reports and review. J Thorac Imaging 1996;11:66–74.

    Article  PubMed  CAS  Google Scholar 

  162. Satta J, Ahonen A, Parkkila S, et al. Multiple endocrine neoplas-tic-associated thymic carcinoid tumour in close relatives: octreotide scan as a new diagnostic and follow-up modality. Two case reports. Scand Cardiovasc J 1999;33:49–53.

    Article  PubMed  CAS  Google Scholar 

  163. de Montpreville VT, Macchiarini P, Dulmet E. Thymic neuroendocrine carcinoma (carcinoid): a clinicopathologic study of fourteen cases. J Thorac Cardiovasc Surg 1996;111:134–141.

    Article  PubMed  Google Scholar 

  164. Fukai I, Masaoka A, Fujii Y, et al. Thymic neuroendocrine tumor (thymic carcinoid): a clinicopathologic study in 15 patients. Ann Thorac Surg 1999;67:208–211.

    Article  PubMed  CAS  Google Scholar 

  165. Moran CA, Rosado-de-Christenson M, Suster S. Thymolipoma: clinicopathologic review of 33 cases [see comments]. Mod Pathol 1995;8:741–744.

    PubMed  CAS  Google Scholar 

  166. Moeller KH, Rosado-de-Christenson ML, Templeton PA. Mediastinal mature teratoma: imaging features. AJR Am J Roentgenol 1997;169:985–990.

    PubMed  CAS  Google Scholar 

  167. Lewis BD, Hurt RD, Payne WS, et al. Benign teratomas of the mediastinum. J Thorac Cardiovasc Surg 1983;86:727–731.

    PubMed  CAS  Google Scholar 

  168. Dulmet EM, Macchiarini P, Sue B, et al. Germ cell tumors of the mediastinum. A 30-year experience. Cancer (Phila) 1993;72:1894–1901.

    Article  PubMed  CAS  Google Scholar 

  169. Moran CA, Suster S. Primary germ cell tumors of the mediastinum: I. Analysis of 322 cases with special emphasis on teratomatous lesions and a proposal for histopathologic classification and clinical staging. Cancer (Phila) 1997;80:681–690.

    Article  PubMed  CAS  Google Scholar 

  170. Hejase MJ, Donohue JP, Foster RS, et al. Post-chemotherapy resection of nonseminomatous germ cell testicular tumors metastatic to the mediastinum. J Urol 1996;156:1345–1348.

    Article  PubMed  CAS  Google Scholar 

  171. Childs WJ, Goldstraw P, Nicholls JE, et al. Primary malignant mediastinal germ cell tumours: Improved prognosis with platinum-based chemotherapy and surgery. Br J Cancer 1993;67:1098–1101.

    PubMed  CAS  Google Scholar 

  172. Jyothirmayi R, Ramadas K, Jacob R, et al. Primary malignant germ cell tumours of the mediastinum—results of multimodal-ity treatment. Acta Oncol 1997;36:317–321.

    Article  PubMed  CAS  Google Scholar 

  173. Moran CA, Suster S, Przygodzki RM, et al. Primary germ cell tumors of the mediastinum: II. Mediastinal seminomas—a clinicopathologic and immunohistochemical study of 120 cases. Cancer (Phila) 1997;80:691–698.

    Article  PubMed  CAS  Google Scholar 

  174. Hidalgo M, Paz-Ares L, Rivera F, et al. Mediastinal nonseminomatous germ cell tumours (MNSGCT) treated with cisplatin-based combination chemotherapy. Ann Oncol 1997;8:555–559.

    Article  PubMed  CAS  Google Scholar 

  175. Moran CA, Suster S, Koss MN. Primary germ cell tumors of the mediastinum: III. Yolk sac tumor, embryonal carcinoma, choriocarcinoma, and combined nonteratomatous germ cell tumors of the mediastinum—a clinicopathologic and immunohistochemical study of 64 cases. Cancer (Phila) 1997;80:699–707.

    Article  PubMed  CAS  Google Scholar 

  176. Israel A, Bosl GJ, Golbey RB, et al. The results of chemotherapy for extragonadal germ-cell tumors in the cisplatin era: the Memorial Sloan-Kettering Cancer Center experience (1975 to 1982). J Clin Oncol 1985;3:1073–1078.

    PubMed  CAS  Google Scholar 

  177. Bebb GG, Grannis FW Jr, Paz IB, et al. Mediastinal germ cell tumor in a child with precocious puberty and Klinefelter syndrome. Ann Thorac Surg 1998;66:547–548.

    Article  PubMed  CAS  Google Scholar 

  178. Logothetis CJ, Samuels ML, Selig DE, et al. Chemotherapy of extragonadal germ cell tumors. J Clin Oncol 1985;3:316–325.

    PubMed  CAS  Google Scholar 

  179. Monig SP, Schmidt R, Krug B. Yolk sac tumor of the anterior mediastinum: the role of palliative surgery. Am Surg 1997;63:948–950.

    PubMed  CAS  Google Scholar 

  180. Hughes JH, Katz RL, Fonseca GA, et al. Fine-needle aspiration cytology of mediastinal non-Hodgkin’s nonlymphoblastic lymphoma. Cancer (Phila) 1998;84:26–35.

    Article  PubMed  CAS  Google Scholar 

  181. Okada Y, Mori H, Maeda T, et al. Congenital mediastinal bronchogenic cyst with malignant transformation: an autopsy report. Pathol Int 1996;46:594–600.

    Article  PubMed  CAS  Google Scholar 

  182. Bierhoff E, Pfeifer U. Malignant mesothelioma arising from a benign mediastinal mesothelial cyst. Gen Diagn Pathol 1996;142:59–62.

    PubMed  CAS  Google Scholar 

  183. Cioffi U, Bonavina L, De Simone M, et al. Presentation and surgical management of bronchogenic and esophageal duplication cysts in adults. Chest 1998;113:1492–1496.

    Article  PubMed  CAS  Google Scholar 

  184. Cuypers P, De Leyn P, Cappelle L, et al. Bronchogenic cysts: a review of 20 cases. Eur J Cardiothorac Surg 1996;10:393–396.

    Article  PubMed  CAS  Google Scholar 

  185. Ribet ME, Copin MC, Gosselin B. Bronchogenic cysts of the mediastinum. J Thorac Cardiovasc Surg 1995;109:1003–1010.

    Article  PubMed  CAS  Google Scholar 

  186. Aktogu S, Yuncu G, Halilcolar H, et al. Bronchogenic cysts: clinicopathological presentation and treatment. Eur Respir J 1996;9:2017–2021.

    Article  PubMed  CAS  Google Scholar 

  187. Demmy TL, Krasna MJ, Detterbeck FC, et al. Multicenter VATS experience with mediastinal tumors. Ann Thorac Surg 1998;66:187–192.

    Article  PubMed  CAS  Google Scholar 

  188. Tripp HF, Reames MK. Resection of a bronchogenic cyst involving the wall of the mainstem bronchus and repair utilizing a pedicled pericardial flap. Am Surg 1997;63:785–787.

    PubMed  CAS  Google Scholar 

  189. Wright CC, Cohen DM, Vegunta RK, et al. Intrathoracic cystic hygroma: a report of three cases. J Pediatr Surg 1996;31:1430–1432.

    Article  PubMed  CAS  Google Scholar 

  190. Chong KT, Ong CL. Cystic hygroma in adulthood. Singapore Med J 1997;38:261–262.

    PubMed  CAS  Google Scholar 

  191. Kim JH, Jun TG, Sung SW, et al. Giant lymph node hyperplasia (Castleman’s disease) in the chest. AnnThoracSurg 1995;59:1162–1165.

    CAS  Google Scholar 

  192. Bowne WB, Lewis JJ, Filippa DA, et al. The management of unicentric and multicentric Castleman’s disease: a report of 16 cases and a review of the literature. Cancer (Phila) 1999;85:706–717.

    Article  PubMed  CAS  Google Scholar 

  193. Shahidi H, Myers JL, Kvale PA. Castleman’s disease. Mayo Clin Proc 1995;70:969–977.

    Article  PubMed  CAS  Google Scholar 

  194. Pandya A, Baumgartner FJ, Nguyen D, et al. Thoracic Castle-man’s disease: implications for resection [letter; comment]. Ann Thorac Surg 1998;65:302–303.

    Article  PubMed  CAS  Google Scholar 

  195. Block MI. Mediastinal tumors. In: Pass HI, Carbone DP, Johnson DH, Minna JD, Turrisi AT, eds. Lung Cancer: Principles and Practice. 3rd edition. Philadelphia: Lippincott, Williams and Wilkins; 2005:894.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Block, M.I. (2008). Mediastinum. In: Norton, J.A., et al. Surgery. Springer, New York, NY. https://doi.org/10.1007/978-0-387-68113-9_76

Download citation

  • DOI: https://doi.org/10.1007/978-0-387-68113-9_76

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-30800-5

  • Online ISBN: 978-0-387-68113-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics