Abstract
In humans we cannot create inbred lines, backcrosses, etc. Consequently, it is more difficult to study directly the correlation of phenotypes and genetic markers. We can proceed indirectly by noting that relatives frequently have more similar phenotypes than non-relatives, presumably because they have more similar genotypes. For studying human diseases, particularly convenient units are affected sib pairs (ASP), which are the subject of this chapter. We delay until Chap. 11 a discussion of the substantially more complex problem of pedigrees involving variable numbers and relationships of affecteds.
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© 2007 Springer Science + Business Media, LLC
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(2007). Mapping Qualitative Traits in Humans Using Affected Sib Pairs. In: The Statistics of Gene Mapping. Statistics for Biology and Health. Springer, New York, NY. https://doi.org/10.1007/978-0-387-49686-3_9
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DOI: https://doi.org/10.1007/978-0-387-49686-3_9
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-49684-9
Online ISBN: 978-0-387-49686-3
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