Synonyms
Bead based assays; Cytometric bead immunoassay; Particle manipulation
Definition
Bead based microfluidic platforms may be used for either particle manipulation or bead based sensing especially in cytometric bead based immunoassays. Bead based microfluidic platforms are often geared to biomedical research and diagnostics particularly in protein diagnostics through immunosorbent assays. For instance, in bead based immunosorbent assays, antigen–antibody reactions are induced on the surface of the bead in the solution and then, the binding event of the antigen–antibody is monitored by fluorescent labeling of either a secondary antigen or antibody. These assays are used to detect biomolecules by utilizing specific ligand-receptor binding reactions. The ligand-receptor binding events may then be quantified by quantifying changes in bead properties using either optical or physical sensing mechanisms. In order to optimize bead based reactions, there has also been considerable interest...
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© 2008 Springer-Verlag
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Yang, S., Zahn, J. (2008). Bead Based Microfluidic Platforms. In: Li, D. (eds) Encyclopedia of Microfluidics and Nanofluidics. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-48998-8_67
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DOI: https://doi.org/10.1007/978-0-387-48998-8_67
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-32468-5
Online ISBN: 978-0-387-48998-8
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