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Chromatographic Chip Devices

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Encyclopedia of Microfluidics and Nanofluidics

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Synonyms

Micro gas and liquid chromatography; μGC; Micro-LC

Definition

Chromatography is one of the most widely used molecular separation techniques. The separation occurs because the compounds within a complex mixture distribute between two phases differently: liquid and stationary phases in the case of liquid chromatography (LC) and gas and stationary phases in the case of gas chromatography (GC). Chromatographic chip devices aim to miniaturize chromatographic systems with the goal not only of size reduction, but also of improved function.

Overview

During a chromatographic separation process, different components of a mixture go through the system at different rates. Repeated sorption/desorption processes that take place during the movement of the sample over the stationary bed determine the rates at which the components are transported. The smaller the affinity a molecule has for the stationary phase, the shorter the time spent in a column. In principle, chromatography can purify...

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References

  1. Terry SC, Jerman JH, Angell JB (1979) IEEE Tans Electron Devices 26:1880

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  2. Lambertus et al (2005) Anal Chem 77:7563

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  3. Lewis PR et al (2006) IEEE Sens J 6:784

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  4. Xie J, Miao YN, Shih J, Tai YC, Lee TD (2005) Anal Chem 77:6947

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  5. Geiser L, et al. (2007) J Chromatogr A 1140:140–146

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Further Reading –

  1. Eiceman GA, Gardea-Torresdey J, Dorman F, Overton E, Bhushan A, Dharmasena HP (2006) Anal Chem 78(12):3985

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  2. Gross GM, Reid VR, Synovec RE (2005) Curr Anal Chem 1(2):135

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  3. Eijkel JCT, van den Berg A (2006) Electrophoresis 27:677–685

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  4. Dittrich PS, Tachikawa K, Manz A (2006) Anal Chem 78:3887–3907

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  5. de Mello A (2002) Lab Chip 2:48N–54

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  6. Nanasek D, Franzke J, Manz A (2006) Nature 442:374–380

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Author information

Authors and Affiliations

  1. Chemistry, Materials Earth and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, USA

    Olgica Bakajin

Authors
  1. Olgica Bakajin
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Editor information

Editors and Affiliations

  1. Department of Mechanical Engineering, Vanderbilt University, VU Station B 351592, 2301 Vanderbilt Place, Nashville, TN, 37235-1592, USA

    Dongqing Li Prof.

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© 2008 Springer-Verlag

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Bakajin, O. (2008). Chromatographic Chip Devices. In: Li, D. (eds) Encyclopedia of Microfluidics and Nanofluidics. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-48998-8_224

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