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Mycoplasma pneumoniae and Other Human Mycoplasmas

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Bacterial Infections of Humans

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Mycoplasmas are a class of fascinating wall-less bacteria that cause disease in humans, animals, and plants. They include species recognized as among the smallest known free-living cells. These microbes have very small genomes and unique genetic features. Their temporary classification as viruses and fastidious growth requirements set the stage early for the use of diagnostic techniques better suited to viral detection and for the well-known difficulties of diagnosing infections in the clinical laboratory. Systemic infections are well known in both immunocompetent and immunocompromised patients, but the host and bacterial factors that allow invasion from epithelial colonization sites are poorly understood. The focus of this chapter will be respiratory and extrapulmonary infections caused by Mycoplasma pneumoniae and genitourinary tract infections caused by M. hominis, M. genitalium, and Ureaplasma species. Some less common mycoplasma infections will also be addressed.

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References

  1. Nocard, E. and E.R. Roux, Le microbe de la peripneumonie. Ann. Inst. Pasteur (Paris), 1898. 12: 240–262.

    Google Scholar 

  2. Klieneberger, E., The natural occurrence of pleuropneumonia-like organisms in apparent symbiosis with Streptobacillus moniliformis and other bacteria. J. Pathol. Bacteriol., 1935. 40: 93–105.

    Article  Google Scholar 

  3. Dienes, L. and G. Edsall, Observations on the L-organisms of Klieneberger. Proc. Soc. Exp. Biol. Med., 1937. 36: 740–744.

    Google Scholar 

  4. Talkington, D.F., et al., Emerging from obscurity: understanding pulmonary and extrapulmonary syndromes, pathogenesis, and epidemiology of human Mycoplasma pneumoniae infections, in Emerging Infections, W.M. Scheld, W.A. Craig, and A.J.M. Hughes, Editors. 2001, American Society for Microbiology: Washington, DC. pp. 57–84.

    Google Scholar 

  5. Waites, K.B. and D.F. Talkington, Mycoplasma pneumoniae and its role as a human pathogen. Clin. Microbiol. Rev., 2004. 17(4): 697–728, table of contents.

    Article  PubMed  CAS  Google Scholar 

  6. Talkington, D.F., Mycoplasma and Ureaplasma in central nervous system disorders., in Infections of the central nervous system, M. Scheld, R. Whitley, and a.C. Marra, Editors. 2005, Lippincott, Williams & Wilkins: Philadelphia, PA. pp. 605–611.

    Google Scholar 

  7. Eaton, M.D., G. Meikeljohn, and W. Van Herick, Studies on the etiology of primary atypical pneumonia: A filterable agent transmissible to cotton rats, hamsters, and chick embryos. J. Exp. Med., 1944. 79: 649–668.

    Article  PubMed  CAS  Google Scholar 

  8. Chanock, R.M., et al., Serologic evidence of infection with Eaton agent in lower respiratory illness of childhood. N. Engl. J. Med., 1960. 262: 648–654.

    Google Scholar 

  9. Chanock, R.M., et al., Respiratory disease in volunteers infected with Eaton agent: A preliminary report. Proc. Natl. Acad. Sci. USA, 1961. 47: 887–890.

    Google Scholar 

  10. Marmion, B.P. and a.G.M. Goodburn, Effect of an inorganic gold salt on Eaton's primary atypical pneumonia agent and other observations. Nature, 1961. 189: 247–248.

    Article  PubMed  CAS  Google Scholar 

  11. Chanock, R.M., et al., Mycoplasma pneumoniae: proposed nomenclature for atypical pneumonia organism (Eaton agent). Science, 1963. 140: 662.

    Article  PubMed  CAS  Google Scholar 

  12. Feikin, D.R., et al., An outbreak of acute respiratory disease caused by Mycoplasma pneumoniae and adenovirus at a federal service training academy: new implications from an old scenario. Clin. Infect. Dis., 1999. 29(6): 1545–1550.

    Article  PubMed  CAS  Google Scholar 

  13. Meseguer, M.A., et al., Mycoplasma pneumoniae pericarditis and cardiac tamponade in a ten-year-old girl. Pediatr. Infect. Dis. J., 1996. 15: 829–831.

    Article  PubMed  CAS  Google Scholar 

  14. Foy, H.M., et al., Epidemiology of Mycoplasma pneumoniae infection in families. JAMA, 1966. 197(11): 859–66.

    Article  PubMed  CAS  Google Scholar 

  15. Marston, B.J., et al., Incidence of community-acquired pneumonia requiring hospitalization. Results of a population-based active surveillance study in Ohio. Arch. Intern. Med., 1997. 157: 1709–1718.

    Article  PubMed  CAS  Google Scholar 

  16. Benisch, B.M., A. Fayemi, M.A. Gerber, and J. Axelrod, Mycoplasmal pneumonia in a patient with rheumatic heart disease. Am. J. Clin. Pathol., 1972. 58: 343–348.

    PubMed  CAS  Google Scholar 

  17. Rawadi, G., and S. Roman-Roman, Mycoplasma membrane lipoproteins induce proinflammatory cytokines by a mechanism distinct from that of lipopolysaccharide. Infect. Immun., 1996. 64: 637–643.

    PubMed  CAS  Google Scholar 

  18. Seggev, J.S., G.V. Sedmak, and V.P. Kurup, Isotype specific antibody responses to acute Mycoplasma pneumoniae infection. Ann. Allergy Asthma Immunol., 1996. 77: 67–73.

    Article  PubMed  CAS  Google Scholar 

  19. Kenney, R.T., et al., Mycoplasma pericarditis: Evidence of invasive disease. Clin. Infect. Dis., 1993. 17(Suppl. 1): S58–S62.

    Article  PubMed  Google Scholar 

  20. Whyte, K.F., and G.R. Williams, Bronchiectasis after mycoplasma pneumonia. Thorax, 1984. 39: 390–391.

    Article  PubMed  CAS  Google Scholar 

  21. Said, M.H., et al., Mycoplasma pneumoniae-associated nephritis in children. Pediatr. Nephrol., 1999. 13: 39–44.

    Article  PubMed  CAS  Google Scholar 

  22. Brouard, J., et al., Mycoplasma pneumoniae respiratory infection in a child presenting with positive HIV 1 serology. Arch. Fr. Pediatr., 1989. 46: 155–156.

    PubMed  CAS  Google Scholar 

  23. Feizi, T., et al., Studies on an epidemic of respiratory disease caused by Mycoplasma pneumoniae. Br. Med. J., 1967. 1:457–460.

    Article  PubMed  CAS  Google Scholar 

  24. Root-Bernstein, R.S. and S.H. Hobbs, Homologies between mycoplasma adhesion peptide, CD4 and class II MHC proteins: a possible mechanism for HIV-mycoplasma synergism in AIDS. Res. Immunol., 1991. 142: 519–523.

    Article  PubMed  CAS  Google Scholar 

  25. Ponka, A., The occurrence and clinical picture of serologically verified Mycoplasma pneumoniae infections with emphasis on central nervous system, cardiac and joint manifestations. Ann. Clin. Res., 1979. 11(Suppl. 24): 1–60.

    PubMed  Google Scholar 

  26. Taylor-Robinson, D., et al., Isolation of Mycoplasma pneumoniae from the synovial fluid of a hypogammaglobulinaemic patient in a survey of patients with inflammatory polyarthritis. Ann. Rheum. Dis., 1978. 37: 180–182.

    Article  PubMed  CAS  Google Scholar 

  27. Weinstein, M.P. and C.B. Hall, Mycoplasma pneumoniae infection associated with migratory polyarthritis. Am. J. Dis. Child., 1974. 127: 125–126.

    PubMed  CAS  Google Scholar 

  28. Baseman, J.B. and J.G. Tully, Mycoplasmas: sophisticated, reemerging, and burdened by their notoriety. Emerg. Infect. Dis., 1997. 3: 21–32.

    Article  PubMed  CAS  Google Scholar 

  29. Chang, Y.T., Yang, Y.H., Chiang, B.L., The significance of a rapid cold hemagglutination test for detecting mycoplasma infections in children with asthma exacerbation. J. Microbiol. Immunol. Infect., 2006. 39(1): 28–32.

    PubMed  Google Scholar 

  30. Tully, J.G., et al., Enhanced isolation of Mycoplasma pneumoniae from throat washings with a newly modified culture medium. J. Infect. Dis., 1979. 139: 478–482.

    Article  PubMed  CAS  Google Scholar 

  31. Waites, K.B., D.F. Talkington, and a.C.M. Bebear, Mycoplasmas, in Manual of commercial methods in clinical microbiology., A.L. Truant, Editor. 2002, American Society for Microbiology: Washington, D.C. pp. 201–224.

    Google Scholar 

  32. Waites, K.B., et al., Laboratory diagnosis of mycoplasmal infections, in Cumitech 34 2001, Washington, D.C.

    Google Scholar 

  33. Ieven, M., et al., Detection of Mycoplasma pneumoniae by two polymerase chain reactions and role of M. pneumoniae in acute respiratory tract infections in pediatric patients. J. Infect. Dis., 1996. 173: 1445–1452.

    Article  PubMed  CAS  Google Scholar 

  34. Dorigo-Zetsma, J.W., et al., Demonstration by a nested PCR for Mycoplasma pneumoniae that M. pneumoniae load in the throat is higher in patients hospitalised for M. pneumoniae infection than in non-hospitalised subjects. J. Med. Microbiol., 1999. 48:1115–1122.

    Article  PubMed  CAS  Google Scholar 

  35. Thacker, W.L. and D.F. Talkington, Analysis of complement fixation and commercial enzyme immunoassays for detection of antibodies to Mycoplasma pneumoniae in human serum. Clin. Diagn. Lab Immunol., 2000. 7(5): 778–80.

    PubMed  CAS  Google Scholar 

  36. Talkington, D.F., et al., Analysis of eight commercial enzyme immunoassay tests for detection of antibodies to Mycoplasma pneumoniae in human serum. Clin. Diagn. Lab Immunol., 2004. 11(5): 862–867.

    PubMed  CAS  Google Scholar 

  37. Thacker, W.L. and D.F. Talkington, Comparison of two rapid commercial tests with complement fixation for serologic diagnosis of Mycoplasma pneumoniae infections. J. Clin. Microbiol., 1995. 33(5): 1212–1214.

    PubMed  CAS  Google Scholar 

  38. Alexander, T.S., et al., Performance of Meridian ImmunoCard Mycoplasma test in a multicenter clinical trial. J. Clin. Microbiol, 1996. 34: 1180–1183.

    PubMed  CAS  Google Scholar 

  39. Matas, L., et al., Evaluation of Meridian ImmunoCard Mycoplasma test for the detection of Mycoplasma pneumoniae specific IgM in paediatric patients. Scand. J. Infect. Dis., 1998. 30:289–293.

    Article  PubMed  CAS  Google Scholar 

  40. Waris, M.E., P. Toikka, T. Saarinen, S. Nikkari, O. Meurman, R. Vainionpaa, O. Ruuskanen and J. Mertsola, Diagnosis of Mycoplasma pneumoniae in children. J. Clin. Microbiol., 1998. 36: 3155–3159.

    PubMed  CAS  Google Scholar 

  41. Chamberlin, P., and A.A. Saeed, A study of the specific IgM antibody response in Mycoplasma pneumoniae in man. J. Hyg. (Cambridge), 1983. 90: 207–211.

    Article  Google Scholar 

  42. Biberfield, G., Antibody responses in Mycoplasma pneumoniae infection in relation to serum immunoglobulins, especially IgM. Acta Pathol. Microbiol. Scand., 1971. Sect. B 79: 620–634.

    Google Scholar 

  43. Vikerfors, T., G. Brodin, M. Grandien, L. Hirschberg, A. Krook, and C.A. and Petterson, Detection of specific IgM antibodies for the diagnosis of Mycoplasma pneumoniae infections: a clinical evaluation. Scand. J. Infect. Dis., 1988. 20: 601–610.

    Article  PubMed  CAS  Google Scholar 

  44. Gerstenecker, B. and E. Jacobs, Development of a capture-ELISA for the specific detection of Mycoplasma pneumoniae in patient’s material., in Rapid diagnosis of mycoplasmas., I. Kahane and a.A. Adoni, Editors. 1993, Plenum Press: New York, N.Y. pp. 195–205.

    Google Scholar 

  45. Kok, T.W., et al., Laboratory diagnosis of Mycoplasma pneumoniae infection. 1. Direct detection of antigen in respiratory exudates by enzyme immunoassay. Epidemiol. Infect., 1988. 101: 669–684.

    Article  PubMed  CAS  Google Scholar 

  46. Hirschberg, L. and T. Holme, ELISA for detection of Mycoplasma pneumoniae antigens using monoclonal antibodies. APMIS, 1991. 99: 475–481.

    Article  PubMed  CAS  Google Scholar 

  47. Bernet, C., et al., Detection of Mycoplasma pneumoniae by using the polymerase chain reaction. J. Clin. Microbiol., 1989. 27: 2492–2496.

    PubMed  CAS  Google Scholar 

  48. Daxboeck, F., R. Krause, and a.C. Wenisch, Laboratory diagnosis of Mycoplasma pneumoniae infection. Clin. Microbiol. Infect., 2003. 9: 263–273.

    Google Scholar 

  49. Loens, K., et al., Molecular diagnosis of Mycoplasma pneumoniae respiratory tract infections. J. Clin. Microbiol., 2003. 41:4915–4923.

    Article  PubMed  CAS  Google Scholar 

  50. Murdoch, D.R., Nucleic acid amplification tests for the diagnosis of pneumonia. Clin. Infect. Dis., 2003. 36: 1162–1170.

    Article  PubMed  CAS  Google Scholar 

  51. Waites, K.B., et al., In vitro susceptibilities to and bactericidal activities of garenoxacin (BMS-284756) and other antimicrobial agents against human mycoplasmas and ureaplasmas. Antimicrob. Agents Chemother., 2003. 47(1): 161–5.

    Article  PubMed  CAS  Google Scholar 

  52. Waites, K.B., D.M. Crabb, and L.B. Duffy, In vitro activities of ABT-773 and other antimicrobials against human mycoplasmas. Antimicrob. Agents Chemother., 2003. 47: 39–42.

    Article  PubMed  CAS  Google Scholar 

  53. Clyde, W.A., Jr., Mycoplasma pneumoniae infections of man, in The mycoplasmas. II. Human and animal mycoplasmas., J.G. Tully and a.R.F. Whitcomb, Editors. 1979, Academic Press: New York, N.Y. pp. 275–306.

    Google Scholar 

  54. Kenny, G.E. and a.F.D. Cartwright, Susceptibilities of Mycoplasma hominis, M. pneumoniae, and Ureaplasma urealyticum to GAR-936, dalfopristin, dirithromycin, evernimicin, gatifloxacin, linezolid, moxifloxacin, quinupristin- dalfopristin, and telithromycin compared to their susceptibilities to reference macrolides, tetracyclines, and quinolones. Antimicrob. Agents Chemother., 2001. 45:2604–2608.

    Article  PubMed  CAS  Google Scholar 

  55. Waites, K.B., D.M. Crabb, and L.B. Duffy, Inhibitory and bactericidal activities of gemifloxacin and other antimicrobials against Mycoplasma pneumoniae. Int. J. Antimicrob. Agents, 2003. 21: 574–577.

    Article  PubMed  CAS  Google Scholar 

  56. Bebear, C.M., et al., Comparative activities of telithromycin (HMR 3647), levofloxacin and other antimicrobial agents against human mycoplasmas. Antimicrob. Agents Chemother., 2000. 47: 1980–1982.

    Article  Google Scholar 

  57. Duffy, L.B., et al., Bactericidal activity of levofloxacin against Mycoplasma pneumoniae. J Antimicrob Chemother, 2003. 52(3): 527–8.

    Article  PubMed  CAS  Google Scholar 

  58. Bebear, C., et al., Potential improvements in therapeutic options for mycoplasmal respiratory infections. Clin. Infect. Dis., 1993. 17(Suppl. 1): S202–S207.

    Article  PubMed  Google Scholar 

  59. Bebear, C.M. and C. Bebear, Antimycoplasmal agents., in Molecular biology and pathogenicity of mycoplasmas., S. Razin and a.R. Herrmann, Editors. 2002, Kluwer Academic/Plenum Publishers: New York, N.Y. pp. 545–566.

    Chapter  Google Scholar 

  60. Niitu, Y., et al., Susceptibility of Mycoplasma pneumoniae to antibiotics in vitro. Jpn. J. Microbiol., 1974. 18: 149–155.

    PubMed  CAS  Google Scholar 

  61. Niitu, Y., et al., Resistance of Mycoplasma pneumoniae to erythromycin and other antibiotics. J. Pediatr., 1970. 76: 438–443.

    Article  PubMed  CAS  Google Scholar 

  62. Stopler, T., C.B. Gerichter, and a.D. Branski, Antibiotic-resistant mutants of Mycoplasma pneumoniae. Isr. J. Med. Sci., 1980. 16: 169–173.

    PubMed  CAS  Google Scholar 

  63. Marrie, T.J., Mycoplasma pneumoniae pneumonia requiring hospitalization, with emphasis on infection in the elderly. Arch. Intern. Med., 1993. 153: 488–494.

    Article  PubMed  CAS  Google Scholar 

  64. Rossi, O.V., V.L. Kinnula, H. Tuokko, and E. Huhti, Respiratory viral and Mycoplasma infections in patients hospitalized for acute asthma. Monaldi Arch. Chest Dis., 1994. 49: 107–111.

    PubMed  CAS  Google Scholar 

  65. Daian, C.M., A.H. Wolff, and L. Bielory, The role of atypical organisms in asthma. Allergy Asthma Proc., 2000. 21: 107–111.

    Article  PubMed  CAS  Google Scholar 

  66. Micillo, E., A. Bianco, D. D’Auria, G. Mazzarella, and G.F. Abbate, Respiratory infections and asthma. Allergy Asthma Proc., 2000. 55 (Suppl 61): 42–45.

    Google Scholar 

  67. Seggev, J.S., et al., Mycoplasma pneumoniae is a frequent cause of exacerbation of bronchial asthma in adults. Ann. Allergy, 1986. 57: 263–265.

    PubMed  CAS  Google Scholar 

  68. Terttu HH, L.M., Nokso-Koivisto J, Korhonen T, Raty R, He Q, Hovi T, Mertsola J, Bloigu A, Rytila P, Saikku P, Non-random distribution of pathogenic bacteria and viruses in induced sputum or pharyngeal secretions of adults with stable asthma. Thorax, 2006. March 3: Electronic preprint.

    Google Scholar 

  69. Gil, J.C., et al., Isolation of Mycoplasma pneumoniae from asthmatic patients. Ann. Allergy, 1993. 70: 23–25.

    PubMed  CAS  Google Scholar 

  70. Kraft, M., et al., Detection of Mycoplasma pneumoniae in the airways of adults with chronic asthma. Am. J. Respir. Crit. Care Med., 1998. 158: 998–1001.

    PubMed  CAS  Google Scholar 

  71. Yano, T., Y. Ichikawa, S. Komatu, S. Arai, and K. Oizumi, Association of Mycoplasma pneumoniae antigen with initial onset of bronchial asthma. Am. J. Respir. Crit. Care Med., 1994. 149: 1348–1353.

    PubMed  CAS  Google Scholar 

  72. Marc, E., et al., Reduced lung diffusion capacity after Mycoplasma pneumoniae pneumonia. Pediatr. Infect. Dis. J., 2000. 19: 706–710.

    Article  PubMed  CAS  Google Scholar 

  73. Sabato, A.R., et al., Mycoplasma pneumoniae: Acute illness, antibiotics, and subsequent pulmonary function. Arch. Dis. Child., 1984. 59: 1034–1037.

    Article  PubMed  CAS  Google Scholar 

  74. Mok, J.Y., P.R. Waugh, and a.H. Simpson, Mycoplasma pneumoniae infection. A follow-up study of 50 children with respiratory illness. Arch. Dis. Child., 1979. 54: 506–511.

    Article  PubMed  CAS  Google Scholar 

  75. Wongtim, S., and S. Mogmued, Methacholine inhalation challenge in patients with post Mycoplasma pneumoniae pneumonia. Asian Pac. J. Allergy Immunol., 1995. 13: 5–10.

    PubMed  CAS  Google Scholar 

  76. Chu, H.W., et al., Substance P and its receptor neurokinin 1 expression in asthmatic airways. J. Allergy Clin. Immunol., 2000. 106: 713–722.

    Article  PubMed  CAS  Google Scholar 

  77. Tipirneni, P., B.S. Moore, J.S. Hyde, and V. Schauf, IgE antibodies to Mycoplasma pneumoniae in asthma and other atopic diseases. Ann. Allergy, 1980. 45: 1–7.

    PubMed  CAS  Google Scholar 

  78. Bar Meir, E., et al., Mycoplasma-pneumoniae-induced thrombotic thrombocytopenic purpura. Acta Haematol., 2000. 103: 112–115.

    Article  PubMed  CAS  Google Scholar 

  79. Koletsky, R.J. and A.J. and Weinstein, Fulminant Mycoplasma pneumoniae infection. Report of a fatal case, and a review of the literature. Am. Rev. Respir: Dis., 1980. 122: 491–496.

    CAS  Google Scholar 

  80. Cassell, G.H. and a.B.C. Cole, Mycoplasmas as agents of human disease. N. Engl. J. Med., 1981. 304: 80–89.

    Google Scholar 

  81. Rautonen, J., M. Koskiniemi, and A. Vaheri, Prognostic factors in childhood acute encephalitis. Pediatr. Infect. Dis. J., 1991. 10: 441–446.

    Article  PubMed  CAS  Google Scholar 

  82. Bitnun A, F.-J.E., Petric M, et al, Acute childhood encephalitis and Mycoplasma pneumoniae. Clin. Infect. Dis., 2001. 32: 1674–1684.

    Article  PubMed  CAS  Google Scholar 

  83. Smith, R. and L. Eviatar, Neurologic manifestations of Mycoplasma pneumoniae infections: diverse spectrum of diseases. A report of six cases and review of the literature. Clin. Pediatr., 2000. 39: 195–201.

    Article  CAS  Google Scholar 

  84. Beskind, D.L. and S.M. Keim, Choreoathetotic movement disorder in a boy with Mycoplasma pneumoniae encephalitis. Ann. Emerg. Med., 1994. 23: 1375–1378.

    Article  PubMed  CAS  Google Scholar 

  85. Keegan, B.M., N.J. Lowry, and J.Y. Yager, Mycoplasma pneumoniae: a cause of coma in the absence of meningoencephalitis. Pediatr. Neurol., 1999. 21: 822–825.

    Article  PubMed  CAS  Google Scholar 

  86. Kikuchi, M., et al., Bickerstaff’s brainstem encephalitis associated with IgG anti-GQ1b antibody subsequent to Mycoplasma pneumoniae infection: favorable response to immunoadsorption therapy. J. Child Neurol., 1997. 12: 403–405.

    Article  PubMed  CAS  Google Scholar 

  87. Decaux, G., et al., Central nervous system complications of Mycoplasma pneumoniae. J. Neurol. Neurosurg. Psychiatr., 1980. 43: 883–887.

    Article  PubMed  CAS  Google Scholar 

  88. Nishimura, M., et al., Post-infectious encephalitis with anti-galactocerebroside antibody subsequent to Mycoplasma pneumoniae infection. J. Neurol. Sci., 1996. 140: 91–95.

    Article  PubMed  CAS  Google Scholar 

  89. Bencina D, D.P., Mueller-Premru M, et al, Intrathecal synthesis of specific antibodies in patients with invasion of the central nervous system by Mycoplasma pneumoniae. Eur. J. Clin. Microbiol. Infect. Dis., 2000. 19: 521–530.

    Article  PubMed  CAS  Google Scholar 

  90. Narita, M., et al., Survey of mycoplasmal bacteremia detected in children by polymerase chain reaction. Clin. Infect. Dis., 1996. 23: 522–525.

    Article  PubMed  CAS  Google Scholar 

  91. Narita, M., O. Itakura, T. Matsuzono, et al, Analysis of mycoplasmal central nervous system involvement by polymerase chain reaction. Pediatr. Infect. Dis. J., 1995. 14: 236–237.

    Article  PubMed  CAS  Google Scholar 

  92. Narita, M, S. Yamada, Two distinct patterns of central nervous system complications due to Mycoplasma pneumoniae infection (Letter). Clin. Infect. Dis., 2001. 33: 916–917.

    Article  PubMed  CAS  Google Scholar 

  93. Pfausler, B., et al., Post-infectious central and peripheral nervous system diseases complicating Mycoplasma pneumoniae infection. Report of three cases and review of the literature. Eur. J. Neurol., 2002. 9: 93–96.

    Article  PubMed  CAS  Google Scholar 

  94. Socan, M., I. Ravnik, D. Bencina, et al., Neurological symptoms in patients whose cerebrospinal fluid is culture- and/or polymerase chain reaction-positive for Mycoplasma pneumoniae. Clin. Infect. Dis., 2001. 32: E31–E33.

    Article  PubMed  CAS  Google Scholar 

  95. Hajjeh, R.A., R.D., P.R. Cieslak, A.N. Sofair,D. Passaro, J. Flood, J. Johnson, J.K. Hacker, W.J. Shieh, R.M. Hendry, S. Nikkari, S. Ladd-Wilson, J. Hadler, J. Rainbow, J.W. Tappero, C.W. Woods, L. Conn, S. Reagan, S. Zaki, and B.A. Perkins, Surveillance for unexplained deaths and critical illnesses due to possibly infectious causes, United States, 1995–1998. Emerg. Infect. Dis., 2002. 8(2): 145–53.

    Article  PubMed  Google Scholar 

  96. Farraj, R.S., et al., Mycoplasma-associated pericarditis. Mayo Clin. Proc., 1997. 72: 33–36.

    Article  PubMed  CAS  Google Scholar 

  97. Karjalainen, J., A loud third heart sound and asymptomatic myocarditis during Mycoplasma pneumoniae infection. Eur. Heart J., 1990. 11: 960–963.

    PubMed  CAS  Google Scholar 

  98. Ponka, A., Carditis associated with Mycoplasma pneumoniae infection. Acta Med. Scand., 1979. 206: 77–86.

    Article  PubMed  CAS  Google Scholar 

  99. Vitullo, B.B., S. O’Regan, J.P. de Chadarevian, and B.S. Kaplan, Mycoplasma pneumonia associated with acute glomerulonephritis. Nephron, 1978. 21: 284–288.

    Google Scholar 

  100. Kanayama, Y., et al., Mycoplasma pneumoniae pneumonia associated with IgA nephropathy. Scand. J. Infect. Dis., 1982. 14: 231–233.

    PubMed  CAS  Google Scholar 

  101. Pasternack, A., et al., Acute tubulointerstitial nephritis in a patient with Mycoplasma pneumoniae infection. Scand. J. Infect. Dis., 1979. 11: 85–87.

    CAS  Google Scholar 

  102. Schulman, P., T.C. Piemonte, and B. Singh, Acute renal failure, hemolytic anemia, and Mycoplasma pneumoniae. JAMA, 1980. 244: 1823–1824.

    Article  PubMed  CAS  Google Scholar 

  103. Von Bonsdorff, M., A. Ponka, and T. Tornroth, Mycoplasmal pneumonia associated with mesangiocapillary glomerulonephritis type II (dense deposit disease). Acta Med. Scand., 1984. 216: 427–429.

    Google Scholar 

  104. Agustin, E.T., V. Gill, and B.A. Cunha, Mycoplasma pneumoniae meningoencephalitis complicated by diplopia. Heart Lung, 1994. 23: 436–437.

    PubMed  CAS  Google Scholar 

  105. Hernandez, L.A., G.E. Urquhart, and W.C. Dick, Mycoplasma pneumoniae infection and arthritis in man. Br. Med. J., 1977. 2: 14–16.

    Article  PubMed  CAS  Google Scholar 

  106. Lambert, H., Syndrome with joint manifestations in association with Mycoplasma pneumoniae infection. Br. Med. J., 1968. iii:156–157.

    Article  Google Scholar 

  107. Taylor-Robinson, D., Mycoplasmal arthritis in man. Isr. J. Med. Sci., 1981. 17: 616–621.

    PubMed  CAS  Google Scholar 

  108. Davis, C.P., et al., Isolation of Mycoplasma pneumoniae from synovial fluid samples in a patient with pneumonia and polyarthritis. Arch. Intern. Med., 1988. 148: 969–970.

    Article  PubMed  CAS  Google Scholar 

  109. Poggio, T.V., N. Orlando, L. Galanternik, and S. Grinstein, Microbiology of acute arthropathies among children in Argentina: Mycoplasma pneumoniae and hominis and Ureaplasma urealyticum. Pediatr. Infect. Dis. J., 1998. 17: 304–308.

    Article  PubMed  CAS  Google Scholar 

  110. Levine, D.P. and A.M. Lerner, The clinical spectrum of Mycoplasma pneumoniae infections. Med. Clin. N. Am., 1978. 62: 961–978.

    PubMed  CAS  Google Scholar 

  111. Levy, M. and N.H. Shear, Mycoplasma pneumoniae infections and Stevens-Johnson syndrome. Report of eight cases and review of the literature. Clin. Pediatr., 1991. 30: 42–49.

    Article  CAS  Google Scholar 

  112. Stevens, D., et al., Mycoplasma pneumoniae infections in children. Arch. Dis. Child., 1978. 53: 38–42.

    Article  PubMed  CAS  Google Scholar 

  113. Fournier, S., S. Bastuji Garin, H. Mentec, J. Revuz, and J.C. Roujeau, Toxic epidermal necrolysis associated with Mycoplasma pneumoniae infection [letter]. Eur. J. Clin. Microbiol. Infect. Dis., 1995. 14: 558–559.

    Article  PubMed  CAS  Google Scholar 

  114. Nagayama, Y., N. Sakurai, and K. Yamamoto, Clinical observations of children with pleuropneumonia due to Mycoplasma pneumoniae. Ped. Pulmonol., 1990. 8: 182–187.

    Article  CAS  Google Scholar 

  115. Macfarlane, J., Mycoplasma pneumoniae infection, antibiotics and exanthema. Infection, 1980. 8: 119–120.

    Article  PubMed  CAS  Google Scholar 

  116. Foy, H.M., C.M. Nolan, and I.D. Allan, Epidemiologic aspects of M. pneumoniae disease complications: a review. Yale J. Biol. Med., 1983. 56: 469–473.

    PubMed  CAS  Google Scholar 

  117. Cherry, J.D., Anemia and mucocutaneous lesions due to Mycoplasma pneumoniae infections. Clin. Infect. Dis., 1993. 17(Suppl. 1): S47–S51.

    Article  PubMed  Google Scholar 

  118. el-Khatib, M. and A.M. Lerner, Myocarditis in Mycoplasma pneumoniae pneumonia. Occurrence with hemolytic anemia and extraordinary titers of cold isohemagglutinins. JAMA, 1975. 231: 493–494.

    Article  PubMed  CAS  Google Scholar 

  119. Simonian, N. and D. Janner, Pleural effusion, hepatitis and hemolytic anemia in a twelve-year-old male child. Pediatr. Infect. Dis. J., 1998. 17: 173–177.

    Article  PubMed  CAS  Google Scholar 

  120. Turtzo, D.F. and P.K. Ghatak, Acute hemolytic anemia with Mycoplasma pneumoniae pneumonia. JAMA, 1976. 236: 1140–1141.

    Article  PubMed  CAS  Google Scholar 

  121. Bar-Meir, E., H. Amital, Y. Levy, A. Kneller, Y. Bar-Dayan, and Y. Shoenfeld, Mycoplasma-pneumoniae-induced thrombotic thrombocytopenic purpura. Acta Haematol., 2000. 103: 112–115.

    Article  PubMed  CAS  Google Scholar 

  122. Stephan, J.L., et al., Aplastic anemia after Mycoplasma pneumoniae infection: a report of two cases. J. Pediatr. Hematol. Oncol., 1999. 21: 299–302.

    Article  PubMed  CAS  Google Scholar 

  123. Control, C.f.D., Outbreaks of Mycoplasma pneumoniae respiratory infection-Ohio, Texas, and New York, 1993. Morbid. Mortal. Weekly Rep., 1993. 42: 931–1039.

    Google Scholar 

  124. Milla, E., L. Zografos, and B. Piguet, Bilateral optic papillitis following Mycoplasma pneumoniae pneumonia. Ophthalmologica, 1998. 212: 344–346.

    Article  PubMed  CAS  Google Scholar 

  125. Salzman, M.B., et al., Ocular manifestations of Mycoplasma pneumoniae infection. Clin. Infect. Dis., 1992. 14: 1137–1139.

    Article  PubMed  CAS  Google Scholar 

  126. Murray, H.W., et al., The protean manifestations of Mycoplasma pneumoniae infection in adults. Am. J. Med., 1975. 58: 229–242.

    Article  PubMed  CAS  Google Scholar 

  127. Arav-Boger, R., et al., Cholestatic hepatitis as a main manifestation of Mycoplasma pneumoniae infection. J. Pediatr. Gastroenterol. Nutr., 1995. 21: 459–460.

    Article  PubMed  CAS  Google Scholar 

  128. Goulet, M., et al., Isolation of Mycoplasma pneumoniae from the human urogenital tract. J. Clin. Microbiol., 1995. 33: 2823–2825.

    PubMed  CAS  Google Scholar 

  129. Edwards, E.A., et al., A longitudinal study of Mycoplasma pneumoniae: infections in Navy recruits by isolation and seroepidemiology. Am. J. Epidemiol., 1976. 104: 556–562.

    PubMed  CAS  Google Scholar 

  130. Gray, G.C., et al., Respiratory diseases among U. S. military personnel: countering emerging threats. Emerg. Infect. Dis., 1999. 5: 379–385.

    Article  PubMed  CAS  Google Scholar 

  131. Gray, G.C., et al., Mycoplasma pneumoniae: a frequent cause of pneumonia among U. S. Marines in southern California. Mil. Med., 1997. 162: 524–526.

    PubMed  CAS  Google Scholar 

  132. Mogabgab, W.J., Mycoplasma pneumoniae and adenovirus respiratory illnesses in military and university personnel, 1959–1966. Am. Rev. Respir. Dis., 1968. 97: 345–379.

    Google Scholar 

  133. Fisher, B., B. Yu, D. Armstrong, and J. Magill, Outbreak of Mycoplasma pneumoniae infection among hospital personnel. Am. J. Med. Sci., 1978. 276: 205–209.

    Article  PubMed  CAS  Google Scholar 

  134. Kashiwagi, S., et al., An outbreak of Mycoplasma pneumoniae infections in a hospital in Japan. Kurume Med. J., 1985. 32: 293–296.

    Article  PubMed  CAS  Google Scholar 

  135. Kleemola, M., C. Jokinen, et al., Outbreak of Mycoplasma pneumoniae infection among hospital personnel studied by a nucleic acid hybridization test. J. Hosp. Infect., 1992. 21: 213–221.

    Article  PubMed  CAS  Google Scholar 

  136. Leibowitz, Z., P. Schvartzman, L. Epstein, I. Lis, and Y. Naot, An outbreak of Mycoplasma pneumoniae pneumonia in two kibbutzim: a clinical and epidemiologic study. Isr. J. Med. Sci., 1988. 24: 88–92.

    PubMed  CAS  Google Scholar 

  137. Muldoon, R.L., et al., An outbreak of Mycoplasma pneumoniae respiratory illness in a semi-closed religious commune. Ann. Emerg. Med., 1982. 11: 613–615.

    Article  PubMed  CAS  Google Scholar 

  138. Hyde, T.B., et al., Azithromycin prophylaxis during a hospital outbreak of Mycoplasma pneumoniae pneumonia. J Infect Dis, 2001. 183(6): 907–912.

    Article  PubMed  CAS  Google Scholar 

  139. Klausner, J.D., et al., Enhanced control of an outbreak of Mycoplasma pneumoniae pneumonia with azithromycin prophylaxis. J Infect Dis, 1998. 177(1): 161–166.

    Article  PubMed  CAS  Google Scholar 

  140. Sterner, G., et al., Acute respiratory illness with Mycoplasma pneumoniae: An outbreak in a home for children. Acta Paediatr. Scand, 1966. 55: 280–286.

    Article  PubMed  CAS  Google Scholar 

  141. Broome, C.V., et al., An explosive outbreak of Mycoplasma pneumoniae infection in a summer camp. Pediatrics, 1980. 66: 884–888.

    PubMed  CAS  Google Scholar 

  142. Gray, G.C., et al., Pneumonia hospitalizations in the US Navy and Marine Corps: rates and risk factors for 6,522 admissions, 1981–1991. Am. J. Epidemiol., 1994. 139: 793–802.

    PubMed  CAS  Google Scholar 

  143. Alexander, E.R., et al., Pneumonia due to Mycoplasma pneumoniae. Its incidence in the membership of a co-operative medical group. N. Engl. J. Med, 1966. 275: 131–136.

    Article  PubMed  CAS  Google Scholar 

  144. Foy, H.M., et al., Mycoplasma pneumoniae pneumonia in an urban area. Five years of surveillance. JAMA, 1970. 214:1666–1672.

    Article  PubMed  CAS  Google Scholar 

  145. Dorigo-Zetsma, J.W., et al., Results of molecular detection of Mycoplasma pneumoniae among patients with acute respiratory infection and in their household contacts reveals children as human reservoirs. J. Infect. Dis., 2001. 183: 675–678.

    Article  PubMed  CAS  Google Scholar 

  146. Balassanian, N. and F.C. Robbins, Mycoplasma pneumoniae infection in families. N. Engl. J. Med., 1967. 277: 719–725.

    CAS  Google Scholar 

  147. Biberfeld, G. and G. Sterner, A study of Mycoplasma pneumoniae infections in families. Scand. J. Infect. Dis., 1969. 1: 39–46.

    PubMed  CAS  Google Scholar 

  148. Foy, H.M., et al., Epidemiology of Mycoplasma pneumoniae infection in families. J. Am. Med. Assoc., 1966. 197: 859–866.

    Article  CAS  Google Scholar 

  149. Jensen, K.J., et al., Mycoplasma pneumoniae infections in children. An epidemiologic appraisal in families treated with oxytetracycline. Am. J. Epidemiol., 1967. 86: 419–432.

    PubMed  CAS  Google Scholar 

  150. Sande, M.A., F. Gadot, and R.P. and Wenzel, Point source epidemic of Mycoplasma pneumoniae infection in a prosthodontics laboratory. Am. Rev. Respir. Dis., 1975. 112: 213–217.

    PubMed  CAS  Google Scholar 

  151. Naftalin, J.M., et al., Letter: Mycoplasma pneumoniae septicemia. JAMA, 1974. 228(5): 565.

    Article  PubMed  CAS  Google Scholar 

  152. Foy, H.M., Infections caused by Mycoplasma pneumoniae and possible carrier state in different populations of patients. Clin. Infect. Dis., 1993. 17(Suppl. 1): S37–S46.

    Article  PubMed  Google Scholar 

  153. Krause, D.C., Mycoplasma pneumoniae cytadherence: organization and assembly of the attachment organelle. Trends Microbiol., 1998. 6: 15–18.

    Article  PubMed  CAS  Google Scholar 

  154. Tryon, V.V. and J.B. Baseman, Pathogenic determinants and mechanisms., in Mycoplasmas: molecular biology and pathogenesis., J. Maniloff, Editor. 1992, American Society for Microbiology: Washington, D.C. pp. 457–471.

    Google Scholar 

  155. Baseman, J.B., M. Lange, N.L. Criscimagna, J.A. Giron, and C.A. Thomas, Interplay between mycoplasmas and host target cells. Microb Pathog 1995. 19: 105–116.

    Article  PubMed  CAS  Google Scholar 

  156. Rottem, S., Invasion of mycoplasmas into and fusion with host cells., in Molecular biology and pathogenicity of mycoplasmas., S. Razin and R. Herrmann, Editors. 2002, Kluwer Academic/Plenum Publishers: New York, N.Y. 391–402.

    Chapter  Google Scholar 

  157. Rottem, S., Interaction of mycoplasmas with host cells. Physiol. Rev., 2003. 83: 417–432.

    PubMed  CAS  Google Scholar 

  158. Somerson, N.L., B.E. Walls, and R.M. Chanock, Hemolysin of Mycoplasma pneumoniae: tentative identification as a peroxide. Science, 1965. 150: 226–228.

    Article  PubMed  CAS  Google Scholar 

  159. Almagor, M., I. Kahane, and S. Yatziv, Role of superoxide anion in host cell injury induced by Mycoplasma pneumoniae infection. A study in normal and trisomy 21 cells. J. Clin. Investig., 1984. 73: 842–847.

    Article  PubMed  CAS  Google Scholar 

  160. Jacobs, E., et al., Immunological reaction of guinea-pigs following intranasal Mycoplasma pneumoniae infection and immunization with the 168 kDa adherence protein. J. Gen. Microbiol., 1988. 134: 473–479.

    PubMed  CAS  Google Scholar 

  161. Loos, M. and H. Brunner, Complement components (C1, C2, C3, C4) in bronchial secretions after intranasal infection of guinea pigs with Mycoplasma pneumoniae: dissociation of unspecific and specific defense mechanisms. Infect Immun, 1979. 25(2): 583–5.

    PubMed  CAS  Google Scholar 

  162. Waites, K.B., et al., Pathogenesis of Mycoplasma pneumoniae infections: adaptive immunity, innate immunity, cell biology, and virulence factors, in Community Acquired Pneumonia, N. Suttorp and R. Marre, Editors 2007, Birkhäuser Publishing: Basel, Switzerland, pp. 183–199.

    Google Scholar 

  163. Yang, J., et al., Cytokines in Mycoplasma pneumoniae infections. Cytokine Growth Factor Rev., 2004. 15(2–3): 157–168.

    Article  PubMed  CAS  Google Scholar 

  164. Carpenter, T., Corticosteroids in the treatment of severe mycoplasma encephalitis in children. Crit. Care Med., 2002. 30:925–927.

    Article  PubMed  Google Scholar 

  165. Gucuyener, K., et al., Methylprednisolone in neurologic complications of Mycoplasma pneumonia. Indian J. Pediatr., 2000. 67: 467–469.

    Article  PubMed  CAS  Google Scholar 

  166. Foy, H.M., Loop, J., Clarke, E.R., Mansy, A.W., Spence, W.F., Feigl, P., et al., Radiographic study of mycoplasma pneumoniae pneumonia. Am. Rev. Respir. Dis., 1973. 108: 469–474.

    PubMed  CAS  Google Scholar 

  167. Morozumi, M., Hasegawa, K., Kobayashi, R., Inoue, N., Iwata, S., Kuroki, H., et al., Emergence of macrolide-resistant Mycoplasma pneumoniae with a 23S rRNA gene mutation. Antimicrob. Agents Chemother., 2005. 49: 2302–2306.

    Article  PubMed  CAS  Google Scholar 

  168. Couch, R.B., Infection with artificially propagated Eaton agent (Mycoplasma pneumoniae): implications for development of attenuated vaccine for cold agglutinin-positive pneumonia. JAMA, 1964. 187: 442–447.

    PubMed  CAS  Google Scholar 

  169. Fernald, G.W. and W.A. Clyde, Jr., Protective effect of vaccines in experimental Mycoplasma pneumoniae disease. Infect. Immun., 1970. 1: 559–565.

    PubMed  CAS  Google Scholar 

  170. Clyde, W.A., Jr., Immunopathology of experimental Mycoplasma pneumoniae disease. Infect. Immun., 1971. 4: 757–763.

    PubMed  Google Scholar 

  171. Clyde, W.A., Jr., Mycoplasma pneumoniae pneumonia. Mil. Med., 1971. 136: 20–22.

    PubMed  Google Scholar 

  172. Fernald, G.W. and W.P. Glezen, Humoral and cellular immune responses to an inactivated Mycoplasma pneumoniae vaccine in children. J. Infect. Dis., 1973. 127: 498–504.

    Article  PubMed  CAS  Google Scholar 

  173. Yayoshi, M., E. Hayatsu, and M. Yoshioka, Protective effects of Mycoplasma pneumoniae live vaccine or its hyperimmune serum on the experimental infection in mice. Kansenshogaku Zasshi, 1989. 63: 684–691.

    PubMed  CAS  Google Scholar 

  174. Cimolai, N., et al., Definition and application of a histopathological scoring scheme for an animal model of acute Mycoplasma pneumoniae pulmonary infection. Microbiol. Immunol., 1992. 36: 465–478.

    PubMed  CAS  Google Scholar 

  175. Yayoshi, M., T. Sasaki, and M. Yoshioka, Relationship between an 85 kDa protein and the protective effects of Mycoplasma pneumoniae. Microbiol. Immunol., 1992. 36: 455–464.

    PubMed  CAS  Google Scholar 

  176. Barile, M.F., et al., Protection of immunized and previously infected chimpanzees challenged with Mycoplasma pneumoniae. Vaccine, 1994. 12: 707–714.

    Article  PubMed  CAS  Google Scholar 

  177. Franzoso, G., et al., Immunoblot analyses of chimpanzee sera after infection and after immunization and challenge with Mycoplasma pneumoniae. Infect. Immun., 1994. 62: 1008–1014.

    PubMed  CAS  Google Scholar 

  178. Cimolai, N., et al., Bases for the early immune response after rechallenge or component vaccination in an animal model of acute Mycoplasma pneumoniae pneumonitis. Vaccine, 1995. 13: 305–309.

    Article  PubMed  CAS  Google Scholar 

  179. Cimolai, N., et al., Mycoplasma pneumoniae reinfection and vaccination: protective oral vaccination and harmful immunoreactivity after re-infection and parenteral immunization. Vaccine, 1996. 14: 1479–1483.

    Article  PubMed  CAS  Google Scholar 

  180. Ellison, J.S., L.D. Olson, and M.F. Barile, Immunity and vaccine development, in Mycoplasmas: molecular biology and pathogenesis., J. Maniloff, et al., Editors. 1992, American Society for Microbiology: Washington, D.C. pp. 491–504.

    Google Scholar 

  181. Barile, M.F., et al., Superiority of the chimpanzee animal model to study the pathogenicity of known Mycoplasma pneumoniae and reputed mycoplasma pathogens. Isr. J. Med. Sci., 1987. 23:556–560.

    PubMed  CAS  Google Scholar 

  182. Steinberg, P., R.L. Horswood, and R.M. Chanock, Temperature-sensitive mutants of Mycoplasma pneumoniae. I. In vitro biologic properties. J. Infect. Dis., 1969. 120: 217–224.

    Article  PubMed  CAS  Google Scholar 

  183. Steinberg, P., et al., Temperature-sensitive mutants of Mycoplasma pneumoniae. II. Response of hamsters. J. Infect. Dis., 1971. 124: 179–187.

    Article  PubMed  CAS  Google Scholar 

  184. Brunner, H., et al., Decreased virulence and protective effect of genetically stable temperature sensitive mutants of Mycoplasma pneumoniae. Ann. N. Y. Acad. Sci., 1973. 225: 436–452.

    Article  Google Scholar 

  185. Greenberg, H., et al., Asymptomatic infection of adult volunteers with a temperature sensitive mutant of Mycoplasma pneumoniae. Proc. Natl. Acad. Sci. USA, 1974. 71: 4015–4019.

    Article  PubMed  CAS  Google Scholar 

  186. Brunner, H., Protective efficacy of Mycoplasma pneumoniae polysaccharides. Isr. J. Med. Sci., 1981. 17: 678–681.

    PubMed  CAS  Google Scholar 

  187. Brunner, H. and B. Prescott, Effect of Mycoplasma pneumoniae polysaccharides and glycolipids on prophylaxis of experimental disease. Semin. Infect. Dis., 1982. 4: 190–197.

    CAS  Google Scholar 

  188. Jacobs, E., et al., Host reactions to Mycoplasma pneumoniae infections in guinea-pigs preimmunized systemically with the adhesin of this pathogen. Microb. Pathog., 1988. 5: 259–265.

    Article  PubMed  CAS  Google Scholar 

  189. Kende, M., Antibody response of animals to Mycoplasma pneumoniae measured by latex agglutination. Appl Microbiol., 1969. 17: 275–279.

    PubMed  CAS  Google Scholar 

  190. Shepard, M.C., The recovery of pleuropneumonia-like organisms from Negro men with and without nongonococcal urethritis. Am. J. Syph. Gonorrhea Vener. Dis., 1954. 38: 113–124.

    PubMed  CAS  Google Scholar 

  191. Tully, J.G., D. Taylor-Robinson, D.L. Rose, R.M. Cole, and J.M. Bove Mycoplasma genitalium, a new species from the human urogenital tract. Int J Sys Bacteriol, 1983. 33: 387–396.

    Article  Google Scholar 

  192. Horowitz, S., B. Evinson, A. Borer, and J. Horowitz, Mycoplasma fermentans in rheumatoid arthritis and other inflammatory arthritides. J Rheumatol, 2000. 27: 2747–2753.

    PubMed  CAS  Google Scholar 

  193. Johnson, S., D. Sidebottom, F. Bruckner, and D. Collins, Identification of Mycoplasma fermentans in synovial fluid samples from arthritis patients with inflammatory disease. J Clin Microbiol, 2000. 38: 90–93.

    PubMed  CAS  Google Scholar 

  194. Blanchard, A., and C. Bebear, Mycoplasmas of humans, in Molecular biology and pathogenicity of Mycoplasmas, Kluwer, S.R.R. Herrmann, Editor. 2002, Academic Plenum Publishers: New York. pp. 45–71.

    Chapter  Google Scholar 

  195. Webster, D., H. Windsor, C. Ling, D. Windsor, and D. Pitcher, Chronic bronchitis in immunocompromised patients: association with a novel Mycoplasma species. Eur. J. Clin. Microbiol. Inf., 2003. 22: 530–534.

    Article  CAS  Google Scholar 

  196. Cassell, G.H., et al., Ureaplasma urealyticum intrauterine infection: role in prematurity and disease in newborns. Clin. Microbiol. Rev., 1993. 6(1): 69–87.

    PubMed  CAS  Google Scholar 

  197. Taylor-Robinson, D., K. Waites, and G. Cassell, Genital Mycoplasmas, in Atlas of Sexually Transmitted Diseases and AIDS, R.C. Ballard, S.A. Morse, K.K. Holmes, and A.A. Moreland Editor. 2003, Mosby: New York. pp. 127–139.

    Google Scholar 

  198. Robertson, J.A., and G.W. Stemke, Expanded serotyping scheme for Ureaplasma urealyticum strains isolated from humans. J. Clin. Microbiol., 1982. 15: 873–878.

    PubMed  CAS  Google Scholar 

  199. Harasawa, R., Genetic relationships among mycoplasmas based on the 16S-23S rRNA spacer sequence. Microbiol. Immunol., 1999. 43: 127–132.

    PubMed  CAS  Google Scholar 

  200. Kong, F., G. James, Z. Ma, S. Gordon, W. Bin, and G.L. Gilbert, Phylogenetic analysis of Ureaplasma urealyticum–support for the establishment of a new species, Ureaplasma parvum. Int. J. Syst. Bacteriol., 1999. 49 Pt 4: 1879–1889.

    Article  PubMed  CAS  Google Scholar 

  201. Kong, F., Z. Ma, G. James, S. Gordon, and G.L. Gilbert, Species identification and subtyping of Ureaplasma parvum and Ureaplasma urealyticum using PCR-based assays. J. Clin. Microbiol., 2000. 38: 1175–1179.

    PubMed  CAS  Google Scholar 

  202. Robertson, J.A., L.A. Howard, C.L. Zinner, and G.W. Stemke, Comparison of 16S rRNA genes within the T960 and parvo biovars of ureaplasmas isolated from humans. Int. J. Syst. Bacteriol., 1994. 44: 836–838.

    Article  PubMed  CAS  Google Scholar 

  203. Robertson, J.A., et al., Proposal of Ureaplasma parvum sp. nov. and emended description of Ureaplasma urealyticum (Shepard et al. 1974). Int. J. Syst. Evol. Microbiol., 2002. 52: 587–597.

    PubMed  Google Scholar 

  204. Robertson, J.A., A. Vekris, C. Bebear, and G.W. Stemke, Polymerase chain reaction using 16S rRNA gene sequences distinguishes the two biovars of Ureaplasma urealyticum. J. Clin. Microbiol., 1993. 31: 824–830.

    PubMed  CAS  Google Scholar 

  205. Kim, M., G. Kim, R. Romero, S.S. Shim, E.C. Kim, and B.H. Yoon, Biovar diversity of Ureaplasma urealyticum in amniotic fluid: distribution, intrauterine inflammatory response and pregnancy outcomes. J. Perinat. Med., 2003. 31: 146–152.

    Article  PubMed  Google Scholar 

  206. Deguchi, T., T. Yoshida, T. Miyazawa, M. Yasuda, M. Tamaki, H. Ishiko, and S. Maeda, Association of Ureaplasma urealyticum (biovar 2) with nongonococcal urethritis. Sex. Transm. Dis., 2004. 31: 192–195.

    Article  PubMed  Google Scholar 

  207. Yoshida, T., H. Ishiko, M. Yasuda, Y. Takahashi, Y. Nomura, Y. Kubota, M. Tamaki, S. Maeda, and T. Deguchi, Polymerase chain reaction-based subtyping of ureaplasma parvum and ureaplasma urealyticum in first-pass urine samples from men with or without urethritis. Sex. Transm. Dis., 2005. 32: 454–457.

    Article  PubMed  CAS  Google Scholar 

  208. Abele-Horn, M., C. Wolff, P. Dressel, F. Pfaff, and A. Zimmermann, Association of Ureaplasma urealyticum biovars with clinical outcome for neonates, obstetric patients, and gynecological patients with pelvic inflammatory disease. J. Clin. Microbiol., 1997. 35: 1199–1202.

    Google Scholar 

  209. Heggie, A.D., D. Bar-Shain, B. Boxerbaum, A.A. Fanaroff, M.A. O’Riordan, and J.A. Robertson, Identification and quantification of ureaplasmas colonizing the respiratory tract and assessment of their role in the development of chronic lung disease in preterm infants. Pediatr. Infect. Dis. J., 2001. 20: 854–859.

    Article  PubMed  CAS  Google Scholar 

  210. Katz, B., P. Patel, L. Duffy, R. Schelonka, R. Dimmitt, and K. Waites, Differential pathogenicity of Ureaplasma urealyticum and Ureaplasma parvum in preterm neonates with bronchopulmonary dysplasia. J. Clin. Microbiol., 2005. 43: 4852–4854.

    Google Scholar 

  211. Mallard, K., K. Schopfer, and T. Bodmer, Development of real-time PCR for the differential detection and quantification of Ureaplasma urealyticum and Ureaplasma parvum. J. Microbiol. Methods, 2005. 60: 13–19.

    Article  PubMed  CAS  Google Scholar 

  212. Cassell, G.H., K.B. Waites, and D.T. Crouse, Mycoplasmal Infections, in Infectious diseases of the Fetus and Newborn Infant, J.S. Remington, J.O. Klein, Editor. 2001, W.B. Saunders Co., Inc: Philadelphia. pp. 733–767.

    Google Scholar 

  213. Dallo, S.F. and J.B. Baseman, Intracellular DNA replication and long-term survival of pathogenic mycoplasmas. Microb. Pathog., 2000. 29: 301–309.

    Article  PubMed  CAS  Google Scholar 

  214. Taylor-Robinson, D., H.A. Davies, P. Sarathchandra, and P.M. Furr, Intracellular location of mycoplasmas in cultured cells demonstrated by immunocytochemistry and electron microscopy. Int J Exp Pathol, 1991. 72: 705–714.

    PubMed  CAS  Google Scholar 

  215. Boesen, T., N.U. Fedosova, M. Kjeldgaard, S. Birkelund, and G. Christiansen, Molecular design of Mycoplasma hominis Vaa adhesin. Protein Sci, 2001. 10: 2577–2586.

    Article  PubMed  CAS  Google Scholar 

  216. Henrich, B., K. Lang, A. Kitzerow, C. MacKenzie, and U. Hadding, Truncation as a novel form of variation of the p50 gene in Mycoplasma hominis. Microbiology, 1998. 144 (Pt 11):2979–2985.

    Article  PubMed  CAS  Google Scholar 

  217. Razin, S., D. Yogev and Y. Naot, Molecular biology and pathogenicity of mycoplasmas. Microbiol. Mol. Biol. Rev., 1998. 62: 1094–1156.

    PubMed  CAS  Google Scholar 

  218. Zhang, Q., and K.S. Wise, Molecular basis of size and antigenic variation of a Mycoplasma hominis adhesin encoded by divergent vaa genes. Infect. Immun., 1996. 64: 2737–2744.

    PubMed  CAS  Google Scholar 

  219. Zheng, X., L.J. Teng, H.L. Watson, J.I. Glass, A. Blanchard, and G.H. Cassell, Small repeating units within the Ureaplasma urealyticum MB antigen gene encode serovar specificity and are associated with antigen size variation. Infect. Immun., 1995. 63:891–898.

    PubMed  CAS  Google Scholar 

  220. Saada, A.B., Y. Terespolski, A. Adoni, and I. Kahane, Adherence of Ureaplasma urealyticum to human erythrocytes. Infect. Immun., 1991. 59: 467–469.

    PubMed  CAS  Google Scholar 

  221. Busolo, F., R. Zanchetta, and G. Bertoloni, Mycoplasmic localization patterns on spermatozoa from infertile men. Fertil. Steril., 1984. 42: 412–417.

    PubMed  CAS  Google Scholar 

  222. Shepard, M.C., and G.K. Masover, Special features of ureaplasmas, in The Mycoplasmas, M.F.Barile, S. Razin, Editor. 1979, Academic Press: New York. pp. 451–494.

    Google Scholar 

  223. Taylor-Robinson, D., P.M. Furr, and A.D. Webster,Ureaplasma urealyticum in the immunocompromised host. Pediatr. Infect. Dis. J., 1986. 5: S236–S238.

    Article  CAS  Google Scholar 

  224. Webster, A.D., P.M. Furr, N.C. Hughes-Jones, B.D. Gorick, and D. Taylor-Robinson, Critical dependence on antibody for defence against mycoplasma. Clin. Exp. Immunol., 1988. 71: 383–387.

    PubMed  CAS  Google Scholar 

  225. Smith, D.G., W.C. Russell, and D. Thirkell, Adherence of Ureaplasma urealyticum to human epithelial cells. Microbiology, 1994. 140 (Pt 10): 2893–2898.

    Article  PubMed  Google Scholar 

  226. Robertson, J.A., M.E. Stemler, and G.W. Stemke. , Immunoglobulin A protease activity of Ureaplasma urealyticum. J. Clin. Microbiol., 1984. 19: 255–258.

    PubMed  CAS  Google Scholar 

  227. Glass, J.I., E.J. Lefkowitz, J.S. Glass, C.R. Heiner, E.Y. Chen, and G.H. Cassell, The complete sequence of the mucosal pathogen Ureaplasma urealyticum. Nature, 2000. 407: 757–762.

    Article  PubMed  CAS  Google Scholar 

  228. De Silva, N.S., and P.A. Quinn, Characterization of phospholipase A1, A2, C activity in Ureaplasma urealyticum membranes. Mol. Cell. Biochem., 1999. 201: 159–167.

    Article  Google Scholar 

  229. De Silva, N.S., and P.A. Quinn, Endogenous activity of phospholipases A and C in Ureaplasma urealyticum. J. Clin. Microbiol., 1986. 23: 354–359.

    PubMed  Google Scholar 

  230. De Silva, N.S., and P.A. Quinn, Localization of endogenous activity of phospholipases A and C in Ureaplasma urealyticum. J. Clin. Microbiol., 1991. 29: 1498–1503.

    PubMed  Google Scholar 

  231. Gelfand, E.W., Unique susceptibility of patients with antibody deficiency to Mycoplasma infection. Clin. Infect. Dis., 1993. 17(Suppl. 1): S250–S253.

    PubMed  Google Scholar 

  232. Waites, K.B., B. Katz, and R.L. Schelonka, Mycoplasmas and ureaplasmas as neonatal pathogens. Clin. Microbiol. Rev., 2005. 18(4): 757–789.

    Article  PubMed  Google Scholar 

  233. Waites, K.B., D.T. Crouse, and G.H. Cassell, Systemic neonatal infection due to Ureaplasma urealyticum. Clin. Infect. Dis., 1993. 17 Suppl 1: S131–5.

    Article  PubMed  Google Scholar 

  234. Cassell, G.H., et al., Association of Ureaplasma urealyticum infection of the lower respiratory tract with chronic lung disease and death in very-low-birth-weight infants. Lancet, 1988. 2(8605):240–245.

    Article  PubMed  CAS  Google Scholar 

  235. Izraeli, S., Z. Samra, L. Sirota, P. Merlob, and S. Davidson, Genital mycoplasmas in preterm infants: prevalence and clinical significance. Eur. J. Pediatr., 1991. 150: 804–807.

    Article  PubMed  CAS  Google Scholar 

  236. Ollikainen, J., H. Hiekkaniemi, M. Korppi, H. Sarkkinen, and K. Heinonen., Ureaplasma urealyticum infection associated with acute respiratory insufficiency and death in premature infants. J. Pediatr., 1993. 122: 756–760.

    Article  PubMed  CAS  Google Scholar 

  237. Cassell, G.H., K.B. Waites, D.T. Crouse, P.T. Rudd, K.C. Canupp, S. Stagno, and G.R. Cutter,Association of Ureaplasma urealyticum infection of the lower respiratory tract with chronic lung disease and death in very-low-birth-weight infants. Lancet, 1988. 2: 240–245.

    Article  PubMed  CAS  Google Scholar 

  238. Foy, H.M., G.E. Kenny, E.M. Levinsohn, and J.T. Grayston, Acquisition of mycoplasmata and T-strains during infancy. J. Infect. Dis., 1970. 121: 579–587.

    Article  PubMed  CAS  Google Scholar 

  239. Waites, K.B., et al., Association of genital mycoplasmas with exudative vaginitis in a 10 year old: a case of misdiagnosis. Pediatrics, 1983. 71(2): 250–2.

    PubMed  CAS  Google Scholar 

  240. Hammerschlag, M.R., B. Doraiswamy, P. Cox, M. Cummings, and W.M. McCormack, Colonization of sexually abused children with genital mycoplasmas. Sex. Transm. Dis., 1987. 14: 23–25.

    Article  PubMed  CAS  Google Scholar 

  241. Waites, K.B., Y. Rikihisa, and D. Taylor-Robinson, Mycoplasma and ureaplasma, in Manual of clinical microbiology, P.R. Murray, et al., Editors. 2003, American Society for Microbiology: Washington, D.C. pp. 972–990.

    Google Scholar 

  242. Bebear, C.M., H. Renaudin, A. Charron, D. Gruson, M. Lefrancois, and C. Bebear, In vitro activity of trovafloxacin compared to those of five antimicrobials against mycoplasmas including Mycoplasma hominis and Ureaplasma urealyticum fluoroquinolone-resistant isolates that have been genetically characterized. Antimicrob. Agents Chemother., 2000. 44: 2557–2260.

    Article  PubMed  CAS  Google Scholar 

  243. Waites, K.B., et al., Comparative in vitro activities of investigational peptide deformylase inhibitor NVP LBM-415 and other agents against human mycoplasmas and ureaplasmas. Antimicrob. Agents Chemother., 2005. 49(6): 2541–2542.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA

    Deborah F. Talkington

  2. Department of Pathology, WP 230, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA

    Ken B. Waites

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  1. Deborah F. Talkington
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  2. Ken B. Waites
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Editors and Affiliations

  1. Rollins School of Public Health, Emory University, Clifton Road NE., 1518, Atlanta, 30322, U.S.A.

    Philip S. Brachman

  2. College of Medicine, Office of Faculty Affairs, Drexel University, Race Street 1505, Philadelphia, 19102, U.S.A.

    Elias Abrutyn

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Talkington, D.F., Waites, K.B. (2009). Mycoplasma pneumoniae and Other Human Mycoplasmas. In: Brachman, P., Abrutyn, E. (eds) Bacterial Infections of Humans. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-09843-2_25

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  • DOI: https://doi.org/10.1007/978-0-387-09843-2_25

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