Skip to main content

The pharmacokinetics and pharmacodynamics of antimicrobial agents in intensive care unit patients as assessed by microdialysis

  • Conference paper
Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E.
  • 979 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Stahl N, Ungerstedt U, Nordstrom CH (2001) Brain energy metabolism during controlled Reduction of cerebral perfusion pressure in severe head injuries. Intensive Care Med 27:1215–1223

    Article  PubMed  CAS  Google Scholar 

  2. Joukhadar C, Stass H, Muller-Zellenberg U et al (2003) Penetration of moxifloxacin into healthy and inflamed subcutaneous adipose tissues in humans. Antimicrob Agents Chemother 47:3099–3103

    Article  PubMed  CAS  Google Scholar 

  3. Muller M, Stass H, Brunner M et al (1999) Penetration of moxifloxacin into peripheral compartments in humans. Antimicrob Agents Chemother 43:2345–2349

    PubMed  CAS  Google Scholar 

  4. Bellmann R, Kuchling G, Dehghanyar P et al (2004) Tissue pharmacokinetics of levofloxacin in human soft tissue infections. Br J Clin Pharmacol 57:563–568

    Article  PubMed  CAS  Google Scholar 

  5. Brunner M, Stabeta H, Moller JG et al (2002) Target site concentrations of ciprofloxacin after single intravenous and oral doses. Antimicrob Agents Chemother 46:3724–3730

    Article  PubMed  CAS  Google Scholar 

  6. Joukhadar C, Klein N, Frossard M et al (2001) Angioplasty increases target site concentrations of ciprofloxacin in patients with peripheral arterial occlusive disease. Clin Pharmacol Ther 70:532–539

    PubMed  CAS  Google Scholar 

  7. Muller M, Brunner M, Hollenstein U et al (1999) Penetration of ciprofloxacin into the interstitial space of inflamed foot lesions in non-insulin-dependent diabetes mellitus patients. Antimicrob Agents Chemother 43:2056–2058

    PubMed  CAS  Google Scholar 

  8. Liu P, Muller M, Grant M et al (2002) Interstitial tissue concentrations of cefpodoxime. J Antimicrob Chemother 50Suppl:19–22

    PubMed  CAS  Google Scholar 

  9. Huovinen P (1999) Antibiotic usage and the incidence of resistance. Clin Microbiol Infect 54:S12–S16

    Article  PubMed  Google Scholar 

  10. Joukhadar C, Frossard M, Mayer BX et al (2001) Impaired target site penetration of beta-lactams may account for therapeutic failure in patients with septic shock. Crit Care Med 29:385–391

    Article  PubMed  CAS  Google Scholar 

  11. Brunner M, Pernerstorfer T, Mayer BX et al (2000) Surgery and intensive care procedures affect the target site distribution of piperacillin. Crit Care Med 28:1754–1759

    Article  PubMed  CAS  Google Scholar 

  12. Tegeder I, Schmidtko A, Brautigam L et al (2002) Tissue distribution of imipenem in critically ill patients. Clin Pharmacol Ther 71:325–333

    Article  PubMed  CAS  Google Scholar 

  13. Joukhadar C, Klein N, Mayer BX et al (2002) Plasma and tissue pharmacokinetics of cefpirome in patients with sepsis. Crit Care Med 30:1478–1482

    Article  PubMed  CAS  Google Scholar 

  14. Joukhadar C, Klein N, Dittrich P et al (2003) Target site penetration of fosfomycin in critically ill patients. J Antimicrob Chemother 51:1247–1252

    Article  PubMed  CAS  Google Scholar 

  15. Zeitlinger MA, Dehghanyar P, Mayer BX et al (2003) Relevance of soft-tissue penetration by levofloxacin for target site bacterial killing in patients with sepsis. Antimicrob Agents Chemother 47:3548–3553

    Article  PubMed  CAS  Google Scholar 

  16. Delacher S, Derendorf H, Hollenstein U et al (2000) A combined in vivo pharmacokinetic-in vitro pharmacodynamic approach to simulate target site pharmacodynamics of antibiotics in humans. J Antimicrob Chemother 46:733–739

    Article  PubMed  CAS  Google Scholar 

  17. Zeitlinger MA, Marsik C, Georgopoulos A et al (2003) Target site bacterial killing of cefpirome and fosfomycin in critically ill patients. Int J Antimicrob Agents 21:562–567

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer-Verlag Italia

About this paper

Cite this paper

Kulemann, V., Joukhadar, C. (2005). The pharmacokinetics and pharmacodynamics of antimicrobial agents in intensive care unit patients as assessed by microdialysis. In: Gullo, A. (eds) Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E.. Springer, Milano. https://doi.org/10.1007/88-470-0351-2_17

Download citation

  • DOI: https://doi.org/10.1007/88-470-0351-2_17

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0288-3

  • Online ISBN: 978-88-470-0351-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics