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Sweet Is the Memory of Past Troubles: NK Cells Remember

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Natural Killer Cells

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 395))

Abstract

Natural killer (NK) cells are important in host defense against tumors and microbial pathogens. Recent studies indicate that NK cells share many features with the adaptive immune system, and like B cells and T cells, NK cells can acquire immunological memory. Here, we review evidence for NK cell memory and the molecules involved in the generation and maintenance of these self-renewing NK cells that provide enhanced protection of the host.

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Acknowledgments

L.L.L. is an American Cancer Society Professor and funded by US National Institutes of Health grants AI066897 and AI068129. G. M-O was a Bisby Fellow of the Canadian Institutes of Health Research. An American Lung Association Senior Research Training Fellowship and University of California President’s Postdoctoral Fellowship funded D.W.H.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, 94143-0414, USA

    Deborah W. Hendricks, Gundula Min-Oo & Lewis L. Lanier

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  1. Deborah W. Hendricks
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  2. Gundula Min-Oo
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  3. Lewis L. Lanier
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Correspondence to Lewis L. Lanier .

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  1. Assistance Publique des Hôpitaux de Marseille, Marseille 05, France and Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université - INSERM - CNRS, Marseille 09, France

    Eric Vivier

  2. INSERM U 668, Pasteur Institute, Paris, Paris, France

    James Di Santo

  3. University of Genoa, Genova, Italy

    Alessandro Moretta

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Hendricks, D.W., Min-Oo, G., Lanier, L.L. (2015). Sweet Is the Memory of Past Troubles: NK Cells Remember. In: Vivier, E., Di Santo, J., Moretta, A. (eds) Natural Killer Cells. Current Topics in Microbiology and Immunology, vol 395. Springer, Cham. https://doi.org/10.1007/82_2015_447

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