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Recent Advances of Asymmetric Catalysis in Flow for Drug Discovery

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Flow Chemistry in Drug Discovery

Part of the book series: Topics in Medicinal Chemistry ((TMC,volume 38))

Abstract

Enantioselective continuous-flow catalysis enables highly efficient synthesis of optically active compounds. The early examples of this field were mainly limited to homogeneous catalysis, and enantioselective heterogeneous flow catalysis remained challenging in terms of activity, selectivity, and lifetime. However, there have been continuous developments in recent years toward highly active and selective chiral heterogeneous catalysts. Besides, technology development enabled in-line workup and analysis of flow reactions to make the process more efficient. This review summarizes the recent achievements of enantioselective flow catalysis mainly focusing on chiral heterogeneous catalysts. Successful examples in recent 5 years are categorized and discussed based on the types of reactions, including transition metal catalysis, organocatalysis, and enzymatic reactions. Multistep-flow synthesis of optically active compounds using enantioselective catalysis is also discussed in the last chapter.

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Authors and Affiliations

  1. Department of Chemistry, School of Science, The University of Tokyo, Tokyo, Japan

    Yuki Saito & Shu Kobayashi

Authors
  1. Yuki Saito
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  2. Shu Kobayashi
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Corresponding author

Correspondence to Shu Kobayashi .

Editor information

Editors and Affiliations

  1. Discovery Chemistry, Janssen Pharmaceutical Companies of J&J, Janssen-Cilag, S.A., Toledo, Spain

    Jesus Alcazar

  2. Faculty of Chemistry, University of Castilla-La Mancha, Ciudad Real, Ciudad Real, Spain

    Antonio de la Hoz

  3. Faculty of Chemistry, University of Castilla-La Mancha, Ciudad Real, Spain

    Angel Díaz-Ortiz

Ethics declarations

Funding: This work was supported in part by a Grant-in-Aid for Scientific Research from Japan Society for the Promotion of Science (JSPS KAKENHI, Grant No. 19K15557) and Japan Science and Technology Agency (JST).

Ethical Approval: This chapter does not contain any studies with human participants or animals performed by any of the authors.

Informed Consent: Informed consent was obtained from all individual participants included in the study.

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Saito, Y., Kobayashi, S. (2021). Recent Advances of Asymmetric Catalysis in Flow for Drug Discovery. In: Alcazar, J., de la Hoz, A., Díaz-Ortiz, A. (eds) Flow Chemistry in Drug Discovery. Topics in Medicinal Chemistry, vol 38. Springer, Cham. https://doi.org/10.1007/7355_2021_128

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