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Inorganic Fluorescent Nanomaterials

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Fluorescent Imaging in Medicinal Chemistry

Part of the book series: Topics in Medicinal Chemistry ((TMC,volume 34))

Abstract

Optical imaging is a noninvasive imaging technology to visualize the specific biological processes by detecting the emissive photons under external energy excitation. In particular, inorganic nanomaterials have attracted great attention as exogenous fluorescent probes for optical imaging due to their superiority in imaging sensitivity, systemic circulation, target specificity, and versatility in chemical design for theranostic purposes. This book chapter comprehensively summarizes the recent advances in inorganic fluorescent nanomaterials, including quantum dots, upconversion, metal nanoclusters, and carbon-based and silicon-based nanomaterials. It will be reviewed in detail the fluorescence mechanism of the nanomaterials based on their optical excitations, the current utility in high-resolution (preclinical) in vivo imaging, and the underlying issues for future clinical translations.

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Authors and Affiliations

  1. Department of NanoEngineering, University of California San Diego, La Jolla, CA, USA

    Taeho Kim & Jesse V. Jokerst

  2. Department of Biomedical Engineering, Michigan State University, East Lansing, MI, USA

    Taeho Kim

  3. Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, MI, USA

    Taeho Kim

  4. Materials Science Program, University of California San Diego, La Jolla, CA, USA

    Jesse V. Jokerst

  5. Department of Radiology, University of California San Diego, La Jolla, CA, USA

    Jesse V. Jokerst

Authors
  1. Taeho Kim
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  2. Jesse V. Jokerst
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Corresponding authors

Correspondence to Taeho Kim or Jesse V. Jokerst .

Editor information

Editors and Affiliations

  1. Stanford University, Stanford, CA, USA

    Zhen Cheng

Ethics declarations

Funding: This work was supported by the NIH R00 117048 and HL 137187.

Conflict of Interest: The authors declare that they have no conflicts of interest.

Ethical approval: This chapter does not contain any studies with human participants or animals performed by any of the authors.

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Kim, T., Jokerst, J.V. (2019). Inorganic Fluorescent Nanomaterials. In: Cheng, Z. (eds) Fluorescent Imaging in Medicinal Chemistry . Topics in Medicinal Chemistry, vol 34. Springer, Cham. https://doi.org/10.1007/7355_2019_85

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