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Tumor Specificity and the Type of Cell Death Induced by Heterocycles

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Bioactive Heterocycles VI

Part of the book series: Topics in Heterocyclic Chemistry ((TOPICS,volume 15))

Abstract

Considering the presence of multiple types of cell death induced by chemicals, it is important to determine a definitive strategy for the exploration of new highly tumor-selective compounds. The screening of highly selective compounds should be performed before the identification of the type of cell death (either apoptosis, autophagy, or necrosis) and the cell death induction mechanism. The tumor specificities of heterocyclic compounds and the type of cell death induced by them are summarized.

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Authors and Affiliations

  1. Division of Pharmacology, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Sakado, 350-0283, Saitama, Japan

    Hiroshi Sakagami & Masaki Kobayashi

  2. Division of Basic Chemistry, Meikai University School of Dentistry, Sakado, 350-0283, Saitama, Japan

    Mariko Ishihara

  3. Division of Endodontics, Meikai University School of Dentistry, Sakado, 350-0283, Saitama, Japan

    Hirotaka Kikuchi & Yukio Nakamura

  4. Faculty of Pharmaceutical Sciences, Matsuyama University, Matsuyama, 790-8578, Ehime, Japan

    Masami Kawase

  5. Meiji Pharmaceutical University, Kiyose, 204-8588, Tokyo, Japan

    Noboru Motohashi

Authors
  1. Hiroshi Sakagami
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  2. Masaki Kobayashi
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  3. Mariko Ishihara
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  4. Hirotaka Kikuchi
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  5. Yukio Nakamura
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  6. Masami Kawase
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  7. Noboru Motohashi
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Correspondence to Hiroshi Sakagami .

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Noboru Motohashi

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Sakagami, H. et al. (2007). Tumor Specificity and the Type of Cell Death Induced by Heterocycles. In: Motohashi, N. (eds) Bioactive Heterocycles VI. Topics in Heterocyclic Chemistry, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7081_2007_103

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