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Vascular Wall as Source of Stem Cells Able to Differentiate into Endothelial Cells

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Cell Biology and Translational Medicine, Volume 7

Part of the book series: Advances in Experimental Medicine and Biology ((CBTMED,volume 1237))

Abstract

The traditional view of the vascular biology is changed by the discovery of vascular progenitor cells in bone marrow or peripheral blood Further complexity is due to the findings that the vessel walls harbor progenitor and stem cells, called vascular wall-resident vascular stem cells (VW-VSCs), able to differentiate to mature vascular wall cells. These immature stem/progenitor cell populations and multipotent mesenchymal lineage participate in postnatal neovascularization and vascular wall remodeling. Further studies are necessary to deepen the knowledge on characterization and biology of VW-VSCs, in particular of endothelial progenitor cells (EPCs) in order to improve their use in clinical settings for regenerative approaches.

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Abbreviations

AC133:

CD133

Adv:

adventitial

BM:

bone marrow

CD:

cluster differentiation

c-kit:

proto-oncogene c-Kit

ECFCs:

endothelial colony-forming cells

EPCs:

endothelial progenitor cells

FOXF-1:

forkhead box F-1

HSCs:

hematopoietic stem cells

KLF4:

Krüppel-like transcription factors

PECAM-1:

platelet/endothelial cell adhesion molecule 1

Sca-1:

stem cells antigen-1

shh:

Sonic Hedgehog

SMCs:

smooth muscle cells

TGF-β:

transforming growth factor beta

VEGFR-2:

vascular endothelial growth factor-2

VW-EPCs:

vascular wall-endothelial progenitor cells

VW-HPCs:

vascular wall- hematopoietic progenitor cells

VWMSCs:

vascular wall-mesenchymal cells

VW-PCs:

vascular wall-progenitor cells

VW-VSCs:

vascular wall-resident vascular stem cells

Wnt:

Wingless-related integration

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Authors and Affiliations

  1. Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy

    Roberto Tamma, Simona Ruggieri, Tiziana Annese & Domenico Ribatti

Authors
  1. Roberto Tamma
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  2. Simona Ruggieri
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  3. Tiziana Annese
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  4. Domenico Ribatti
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Corresponding author

Correspondence to Domenico Ribatti .

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Editors and Affiliations

  1. Ottawa Hospital Research Institute, Ottawa, ON, Canada

    Kursad Turksen

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Tamma, R., Ruggieri, S., Annese, T., Ribatti, D. (2019). Vascular Wall as Source of Stem Cells Able to Differentiate into Endothelial Cells. In: Turksen, K. (eds) Cell Biology and Translational Medicine, Volume 7. Advances in Experimental Medicine and Biology(), vol 1237. Springer, Cham. https://doi.org/10.1007/5584_2019_421

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