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Red Blood Cell Substitutes: Past, Present, and Future

  • Conference paper
Artificial Oxygen Carrier

Part of the book series: Keio University International Symposia for Life Sciences and Medicine ((KEIO,volume 12))

Summary

Polyhemoglobin is already well into the final stages of clinical trials in humans. One has been approved for routine clinical use in South Africa. Perfluorochemicals are chemical oxygen carriers that are being actively developed with some in the advanced stages of clinical trials. Meanwhile, new generations of modified Hb are being developed that can modulate the effects of nitric oxide. Other systems are also being developed to include antioxidant properties for those clinical applications that may have potential problems related to oxygen radicals. Other products in advanced stages of animal testing are based on hemoglobin-lipid vesicles, heme-albumin and heme-lipid vesicles. A further development is the use of nanotechnology and biodegradable copolymers to prepare nano-dimension artificial red blood cells containing hemoglobin and complex enzyme systems.

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Authors and Affiliations

  1. Artificial Cells & Organs Research Centre, MSSS-FRSQ Research Group on Blood Substitutes in Transfusion Medicine, Faculty of Medicine, McGill University, 3655 Drummond Street, Montreal, Quebec, Canada, H3G 1Y6

    Thomas Ming Swi Chang

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  1. Thomas Ming Swi Chang
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Editors and Affiliations

  1. Division of General Thoracic Surgery, Department of Surgery School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan

    Koichi Kobayashi M.D., Ph.D. (Chief Professor of Surgery) & Hirohisa Horinouchi M.D., Ph.D. (Chief Professor of Surgery) & 

  2. Department of Polymer Chemistry, Waseda University, 3-4-1 Ohkubo, Shinjuku-ku, Tokyo, 169-8555, Japan

    Eishun Tsuchida Ph.D. (Professor Emeritus) (Professor Emeritus)

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© 2005 Springer-Verlag Tokyo

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Chang, T.M.S. (2005). Red Blood Cell Substitutes: Past, Present, and Future. In: Kobayashi, K., Tsuchida, E., Horinouchi, H. (eds) Artificial Oxygen Carrier. Keio University International Symposia for Life Sciences and Medicine, vol 12. Springer, Tokyo. https://doi.org/10.1007/4-431-26651-8_2

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  • DOI: https://doi.org/10.1007/4-431-26651-8_2

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-22074-9

  • Online ISBN: 978-4-431-26651-8

  • eBook Packages: MedicineMedicine (R0)

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