Skip to main content
SpringerLink
Log in

Heterogeneity in rheumatoid arthritis based on expression analysis: towards personalised medicine

  • Chapter
The Hereditary Basis of Rheumatic Diseases

Part of the book series: Progress in Inflammation Research ((PIR))

  • 536 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS et al (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315–324

    PubMed  CAS  Google Scholar 

  2. Arnett FC (1989) Revised criteria for the classification of rheumatoid arthritis. Bull Rheum Dis 38: 1–6

    PubMed  CAS  Google Scholar 

  3. Tak PP, Smeets TJ, Daha MR, Kluin PM, Meijers KA, Brand R, Meinders AE, Breedveld FC (1997) Analysis of the synovial cell infiltrate in early rheumatoid synovial tissue in relation to local disease activity. Arthritis Rheum 40: 217–225

    PubMed  CAS  Google Scholar 

  4. Klimiuk PA, Goronzy JJ, Bjor nJ, Beckenbaugh RD, Weyand CM (1997) Tissue cytokine patterns distinguish variants of rheumatoid synovitis. Am J Pathol 151: 1311–1319

    PubMed  CAS  Google Scholar 

  5. Ulfgren AK, Grondal L, Lindblad S, Khademi M, Johnell O, Klareskog L, Andersson U (2000) Interindividual and intra-articular variation of proinflammatory cytokines in patients with rheumatoid arthritis: potential implications for treatment. Ann Rheum Dis 59: 439–447

    Article  PubMed  CAS  Google Scholar 

  6. Takemura S, Braun A, Crowson C, Kurtin PJ, Cofield RH, O’Fallon WM, Goronzy JJ, Weyand CM (2001) Lymphoid neogenesis in rheumatoid synovitis. J Immunol 167:1072–1080

    PubMed  CAS  Google Scholar 

  7. Elliott MJ, Maini RN, Feldmann M, Kalden JR, Antoni C, Smolen JS, Leeb B, Breedveld FC, Macfarlane JD, Bijl H et al (1994) Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis. Lancet 344: 1105–1110

    Article  PubMed  CAS  Google Scholar 

  8. Elliott MJ, Maini RN, Feldmann M, Long-Fox A, Charles P, Katsikis P, Brennan FM, Walker J, Bijl H, Ghrayeb J et al (1993) Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha. Arthritis Rheum 36: 1681–1690

    PubMed  CAS  Google Scholar 

  9. Kremer JM, Westhovens R, Leon M, Di Giorgio E, Alten R, Steinfeld S, Russell A, Dougados M, Emery P, Nuamah IF et al (2003) Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig. N Engl J Med 349:1907–1915

    Article  PubMed  CAS  Google Scholar 

  10. Edwards JC, Szczepanski L, Szechinski J, Filipowicz-Sosnowska A, Emery P, Close DR, Stevens RM, Shaw T (2004) Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. N Engl J Med 350: 2572–2581

    Article  PubMed  CAS  Google Scholar 

  11. Schellekens GA, de Jong BA, van den Hoogen FH, van de Putte LB, van Venrooij WJ (1998) Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies. J Clin Invest 101: 273–281

    Article  PubMed  CAS  Google Scholar 

  12. van Zeben D, Hazes JM, Zwinderman AH, Cats A, van der Voort EA, Breedveld FC (1992) Clinical significance of rheumatoid factors in early rheumatoid arthritis: results of a follow up study. Ann Rheum Dis 51: 1029–1035

    Article  PubMed  Google Scholar 

  13. Rantapaa-Dahlqvist S, de Jong BA, Berglin E, Hallmans G, Wadell G, Stenlund H, Sundin U, van Venrooij WJ (2003) Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum 48: 2741–2749

    Article  PubMed  CAS  Google Scholar 

  14. Nielen MM, van Schaardenburg D, Reesink HW, van de Stadt RJ, van der Horst-Bruinsma IE, de Koning MH, Habibuw MR, Vandenbroucke JP, Dijkmans BA (2004) Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors. Arthritis Rheum 50: 380–386

    Article  PubMed  Google Scholar 

  15. Berglin E, Padyukov L, Sundin U, Hallmans G, Stenlund H, van Venrooij WJ, Klareskog L, Dahlqvist SR (2004) A combination of autoantibodies to cyclic citrullinated peptide (CCP) and HLA-DRB1 locus antigens is strongly associated with future onset of rheumatoid arthritis. Arthritis Res Ther 6: R303–R308

    Article  PubMed  CAS  Google Scholar 

  16. Van Gaalen FA, Linn-Rasker SP, van Venrooij WJ, de Jong BA, Breedveld FC, Verweij CL, Toes RE, Huizinga TW (2004) Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis: a prospective cohort study. Arthritis Rheum. 50: 709–715

    Article  PubMed  CAS  Google Scholar 

  17. Bongi SM, Manetti R, Melchiorre D, Turchini S, Boccaccini P, Vanni L, Maggi E (2004) Anti-cyclic citrullinated peptide antibodies are highly associated with severe bone lesions in rheumatoid arthritis anti-CCP and bone damage in RA. Autoimmunity 37: 495–501

    Article  PubMed  CAS  Google Scholar 

  18. Lindqvist E, Eberhardt K, Bendtzen K, Heinegard D, Saxne T (2005) Prognostic laboratory markers of joint damage in rheumatoid arthritis. Ann Rheum Dis 64: 196–201

    Article  PubMed  CAS  Google Scholar 

  19. Robinson WH, DiGennaro C, Hueber W, Haab BB, Kamachi M, Dean EJ, Fournel S, Fong D, Genovese MC, de Vegvar HE et al (2002) Autoantigen microarrays for multiplex characterization of autoantibody responses. Nat Med 8: 295–301

    Article  PubMed  CAS  Google Scholar 

  20. Drynda S, Ringel B, Kekow M, Kuhne C, Drynda A, Glocker MO, Thiesen HJ, Kekow J (2004) Proteome analysis reveals disease-associated marker proteins to differentiate RA patients from other inflammatory joint diseases with the potential to monitor anti-TNFalpha therapy. Pathol Res Pract 200: 165–171

    Article  PubMed  CAS  Google Scholar 

  21. Roth J, Vogl T, Sorg C, Sunderkotter C (2003) Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules. Trends Immunol 24: 155–158

    Article  PubMed  CAS  Google Scholar 

  22. Liao H, Wu J, Kuhn E, Chin W, Chang B, Jones MD, O’Neil S, Clauser KR, Karl J, Hasler F et al (2004) Use of mass spectrometry to identify protein biomarkers of disease severity in the synovial fluid and serum of patients with rheumatoid arthritis. Arthritis Rheum 50: 3792–3803

    Article  PubMed  CAS  Google Scholar 

  23. Alizadeh AA, Eisen MB, Davis RE, Ma C, Lossos IS, Rosenwald A, Boldrick JC, Sabet H, Tran T, Yu X et al (2000) Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 403: 503–511

    Article  PubMed  CAS  Google Scholar 

  24. van de Vijver MJ, He YD, van’t Veer LJ, Dai H, Hart AA, Voskuil DW, Schreiber GJ, Peterse JL, Roberts C, Marton MJ et al (2002) A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med 347: 1999–2009

    Article  PubMed  Google Scholar 

  25. Bovin LF, Rieneck K, Workman C, Nielsen H, Sorensen SF, Skjodt H, Florescu A, Brunak S, Bendtzen K (2004) Blood cell gene expression profiling in rheumatoid arthritis. Discriminative genes and effect of rheumatoid factor. Immunol Lett 93: 217–226

    Article  PubMed  CAS  Google Scholar 

  26. Olsen N, Sokka T, Seehorn CL, Kraft B, Maas K, Moore J, Aune TM (2004) A gene expression signature for recent onset rheumatoid arthritis in peripheral blood mononuclear cells. Ann Rheum Dis 63: 1387–1392

    Article  PubMed  CAS  Google Scholar 

  27. van der Pouw Kraan TC, Van Gaalen FA, Kasperkovitz PV, Verbeet NL, Smeets TJ, Kraan MC, Fero M, Tak PP, Huizinga TW, Pieterman E et al (2003) Rheumatoid arthritis is a heterogeneous disease: Evidence for differences in the activation of the STAT-1 pathway between rheumatoid tissues. Arthritis Rheum 48: 2132–2145

    Article  PubMed  CAS  Google Scholar 

  28. van der Pouw Kraan TC, Van Gaalen FA, Huizinga TW, Pieterman E, Breedveld FC, Verweij CL (2003) Discovery of distinctive gene expression profiles in rheumatoid synovium using cDNA microarray technology: evidence for the existence of multiple pathways of tissue destruction and repair. Genes Immun 4: 187–196

    Article  PubMed  CAS  Google Scholar 

  29. Lehtonen A, Matikainen S, Julkunen I (1997) Interferons up-regulate STAT1, STAT2, and IRF family transcription factor gene expression in human peripheral blood mononuclear cells and macrophages. J Immunol 159: 794–803

    PubMed  CAS  Google Scholar 

  30. Tibshirani R, Hastie T, Narasimhan B, Chu G (2002) Diagnosis of multiple cancer types by shrunken centroids of gene expression. Proc Natl Acad Sci USA 99: 6567–6572

    Article  PubMed  CAS  Google Scholar 

  31. Chang HY, Chi JT, Dudoit S, Bondre C, van de R M, Botstein D, Brown PO (2002) Diversity, topographic differentiation, and positional memory in human fibroblasts. Proc Natl Acad Sci USA 99: 12877–12882

    Article  PubMed  CAS  Google Scholar 

  32. Smith RS, Smith TJ, Blieden TM, Phipps RP (1997) Fibroblasts as sentinel cells. Synthesis of chemokines and regulation of inflammation. Am J Pathol 151: 317–322

    PubMed  CAS  Google Scholar 

  33. Brouty-Boye D, Pottin-Clemenceau C, Doucet C, Jasmin C, Azzarone B (2000) Chemokines and CD40 expression in human fibroblasts. Eur J Immunol 30: 914–919

    Article  PubMed  CAS  Google Scholar 

  34. Hogaboam CM, Steinhauser ML, Chensue SW, Kunkel SL (1998) Novel roles for chemokines and fibroblasts in interstitial fibrosis. Kidney Int 54: 2152–2159

    Article  PubMed  CAS  Google Scholar 

  35. Firestein GS, Zvaifler NJ (2002) How important are T cells in chronic rheumatoid synovitis?: II. T cell-independent mechanisms from beginning to end. Arthritis Rheum 46:298–308

    Article  PubMed  CAS  Google Scholar 

  36. Kasperkovitz PV, Timmer TC, Smeets TJ, Verbeet NL, Tak PP, van Baarsen LG, Baltus B, Huizinga TW, Pieterman E, Fero M et al (2005) Fibroblast-like synoviocytes derived from patients with rheumatoid arthritis show the imprint of synovial tissue heterogeneity: Evidence of a link between an increased myofibroblast-like phenotype and high-inflammation synovitis. Arthritis Rheum 52: 430–441

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Molecular Cell Biology and Immunology, C270, VU Medical Centre, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands

    Cornelis L. Verweij & Tineke C. T. M. van der Pouw Kraan

Authors
  1. Cornelis L. Verweij
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tineke C. T. M. van der Pouw Kraan
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Section for Medical Inflammation Research, Department of Cell and Molecular Biology, Lund University, Solvegatan 19, I11 BMC, S-221 84, Lund, Sweden

    Rikard Holmdahl

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Birkhäuser Verlag Basel/Switzerland

About this chapter

Cite this chapter

Verweij, C.L., van der Pouw Kraan, T.C.T.M. (2006). Heterogeneity in rheumatoid arthritis based on expression analysis: towards personalised medicine. In: Holmdahl, R. (eds) The Hereditary Basis of Rheumatic Diseases. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7419-5_3

Download citation

  • DOI: https://doi.org/10.1007/3-7643-7419-5_3

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-7643-7201-9

  • Online ISBN: 978-3-7643-7419-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation