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Aluminofluoride Complexes in the Etiology of Alzheimer’s Disease

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Group 13 Chemistry II

Part of the book series: Structure and Bonding ((STRUCTURE,volume 104))

Abstract

The question of aluminum’s relevance to the etiology of Alzheimer’s disease cannot yet be adequately answered. The mechanisms of how aluminum could evoke the hallmarks of AD are not known. Reflecting many studies, which utilize aluminofluoride complexes in laboratory investigations, we suggest that these complexes may act as the initial signal stimulating impairment of homeostasis, degeneration, and death of the cells. Aluminum ions in the presence of fluoride can accelerate the aging and impair the functions of the nervous system. In respect to the etiology of Alzheimer’s disease, the long-term synergistic action of aluminum ions and fluorides may represent a hidden but serious and powerful risk factor for the development of this devastating threat to human civilization.

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Authors and Affiliations

  1. Faculty of Science, Department of Physiology and Developmental Physiology, Charles University Prague, Vinicna 7, 128 00, Prague 2, Czech Republic

    Anna Strunecká

  2. Department of Toxicology, Military Medical Academy, Simkova 878, 500 01, Hradec Kralove, Czech Republic

    Jiri Patočka

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  1. Anna Strunecká
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  2. Jiri Patočka
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Editors and Affiliations

  1. Institut für Anorganische Chemie der Universität Göttingen, Tammannstr. 4, 37077, Göttingen, Germany

    Herbert W. Roesky

  2. Department of Chemistry, University of Kentucky, Lexington, Kentucky, 40506 0055, USA

    David A. Atwood

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Strunecká, A., Patočka, J. (2002). Aluminofluoride Complexes in the Etiology of Alzheimer’s Disease. In: Roesky, H.W., Atwood, D.A. (eds) Group 13 Chemistry II. Structure and Bonding, vol 104. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-45425-X_5

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  • DOI: https://doi.org/10.1007/3-540-45425-X_5

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