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Multi-objective Optimisation of Cancer Chemotherapy Using Evolutionary Algorithms

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Evolutionary Multi-Criterion Optimization (EMO 2001)

Part of the book series: Lecture Notes in Computer Science ((LNCS,volume 1993))

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Abstract

The main objectives of cancer treatment in general, and of cancer chemotherapy in particular, are to eradicate the tumour and to prolong the patient survival time. Traditionally, treatments are optimised with only one objective in mind. As a result of this, a particular patient may be treated in the wrong way if the decision about the most appropriate treatment objective was inadequate. To partially alleviate this problem, we show in this paper how the multi-objective approach to chemotherapy optimisation can be used. This approach provides the oncologist with versatile treatment strategies that can be applied in ambiguous cases. However, the conflicting nature of treatment objectives and the non-linearity of some of the constraints imposed on treatment schedules make it difficult to utilise traditional methods of multi-objective optimisation. Evolutionary Algorithms (EA), on the other hand, are often seen as the most suitable method for tackling the problems exhibiting such characteristics. Our present study proves this to be true and shows that EA are capable of finding solutions undetectable by other optimisation techniques.

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Author information

Authors and Affiliations

  1. School of Computer and Mathematical Sciences, The Robert Gordon University, St. Andrew Street, AB25 1HG, ABERDEEN, UK

    Andrei Petrovski & John McCall

Authors
  1. Andrei Petrovski
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  2. John McCall
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Editor information

Editors and Affiliations

  1. Department of Electrical Engineering Computer Engineering and Networks Laboratory, Swiss Federal Institute of Technology, ETH Zentrum, Gloriastrasse 35, 8092, Zurich, Switzerland

    Eckart Zitzler  & Lothar Thiele  & 

  2. Department of Mechanical Engineering Kanpur Genetic Algorithms Laboratory, Indian Institute of Technology, UP 208 016, Kanpur, India

    Kalyanmoy Deb

  3. Electrical Engineering Department,Computer Science Section Av.Instituto Politecnico Nacional No.2508, CINVESTAV-IPN, Col.San Pedro Zacatenco, 07300, Mexico City, Mexico

    Carlos Artemio Coello Coello

  4. Department of Computer Science, University of Reading, P.O.Box 225, Reading RG6 6AY, Whiteknights, UK

    David Corne

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© 2001 Springer-Verlag Berlin Heidelberg

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Petrovski, A., McCall, J. (2001). Multi-objective Optimisation of Cancer Chemotherapy Using Evolutionary Algorithms. In: Zitzler, E., Thiele, L., Deb, K., Coello Coello, C.A., Corne, D. (eds) Evolutionary Multi-Criterion Optimization. EMO 2001. Lecture Notes in Computer Science, vol 1993. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-44719-9_37

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  • DOI: https://doi.org/10.1007/3-540-44719-9_37

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-41745-3

  • Online ISBN: 978-3-540-44719-1

  • eBook Packages: Springer Book Archive

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