Pharmacokinetic & -dynamic Drug Information and Dosage Adjustment System Pharmdis

Abstract

Not only every patient is different, but also every drug. Drug dosage must be individualised, and adjusted to the patient’s organ func- tion (e.g. age, kidney) and severity of disease (e.g. intensive care, outpa- tient office). Within an European project, we are on the way to built up a drug information and dosage adjustment system. The essential compo- nents are available: the pharmacokinetic /-dynamic database NEPharm, calculation algorithms, a consensus on general pharmacokinetic concept, on dose adjustment rules, and on standard nomenclature (ATC code). A graphical user interface must be designed. The required components must be made interoperable, namely patient record, drug dictionary, phar- macokinetic /-dynamic database, calculation algorithms, graphical user interface. The dosage proposals made by the system must be clinically certified, and be compared to standard practice in an external environ- ment to evaluate clinical applicability and reliability. Special versions of the system will be designed for the needs of our software partners. The integrated system will be implemented to establish an internet-based centre of excellence for individualised drug therapy.