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Carnitine O-octanoyltransferase

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Springer Handbook of Enzymes

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References

  1. Solberg, H.E.: Different carnitine acyltransferases in calf liver. Biochim. Biophys. Acta, 280, 422–433 (1972)

    PubMed  CAS  Google Scholar 

  2. Solberg, H.E.: Acyl group specificity of mitochondrial pools of carnitine acyltransferases. Biochim. Biophys. Acta, 360, 101–112 (1974)

    PubMed  CAS  Google Scholar 

  3. Markwell, M.A.K.; Tolbert, N.E.; Bieber, L.L.: Comparison of the carnitine acyltransferase activities from rat liver peroxisomes and microsomes. Arch. Biochem. Biophys., 176, 479–488 (1976)

    Article  CAS  Google Scholar 

  4. Saggerson, E.D.; Carpenter, C.A.: Malonyl CoA inhibition of carnitine acyltransferase activities: effects of thiol-group reagents. FEBS Lett., 137, 124–128 (1982)

    Article  PubMed  CAS  Google Scholar 

  5. Farrell, S.O.; Bieber, L.L.: Carnitine octanoyltransferase of mouse liver peroxisomes: properties and effect of hypolipidemic drugs. Arch. Biochem. Biophys., 222, 123–132 (1983)

    Article  PubMed  CAS  Google Scholar 

  6. Farrell, S.O.; Fiol, C.J.; Reddy, J.K.; Bieber, L.L.: Properties of purified carnitine acyltransferases of mouse liver peroxisomes. J. Biol. Chem., 259, 13089–13095 (1984)

    PubMed  CAS  Google Scholar 

  7. Bird, M.I.; Munday, L.A.; Saggerson, E.D.; Clark, J.B.: Carnitine acyltransferase activities in rat brain mitochondria. Bimodal distribution, kinetic constants, regulation by malonyl-CoA and developmental pattern. Biochem. J., 226, 323–330 (1985)

    PubMed  CAS  Google Scholar 

  8. Healy, M.J.; Kerner, J.; Bieber, L.L.: Enzymes of carnitine acylation. Is overt carnitine palmitoyltransferase of liver peroxisomal carnitine octanoyltransferase?. Biochem. J., 249, 231–237 (1988)

    PubMed  CAS  Google Scholar 

  9. Lilly, K.; Bugaisky, G.E.; Umeda, P.K.; Bieber, L.L.: The medium-chain carnitine acyltransferase activity associated with rat liver microsomes is mal-onyl-CoA sensitive. Arch. Biochem. Biophys., 280, 167–174 (1990)

    Article  PubMed  CAS  Google Scholar 

  10. Nic A’Bhaird, N.; Ramsay, R.R.: Malonyl-CoA inhibition of peroxisomal carnitine octanoyltransferase. Biochem. J., 286, 637–640 (1992)

    CAS  Google Scholar 

  11. Chung, CD.; Bieber, L.L.: Properties of the medium chain/long chain carnitine acyltransferase purified from rat liver microsomes. J. Biol. Chem., 268, 4519–4524 (1993)

    PubMed  CAS  Google Scholar 

  12. Pagot, Y.; Belin, J.M.: Involvement of carnitine acyltransferases in peroxisomal fatty acid metabolism by the yeast Pichia guilliermondii. Appl. Environ. Microbiol., 62, 3864–3867 (1996)

    PubMed  CAS  Google Scholar 

  13. Cronin, C.N.: The conserved serine-threonine-serine motif of the carnitine acyltransferases is involved in carnitine binding and transition-state stabilization: a site-directed mutagenesis study. Biochem. Biophys. Res. Commun., 238, 784–789 (1997)

    Article  PubMed  CAS  Google Scholar 

  14. Cronin, C.N.: cDNA cloning, recombinant expression, and site-directed mutagenesis of bovine liver carnitine octanoyltransferase. Arg505 binds the carboxylate group of carnitine. Eur. J. Biochem., 247, 1029–1037 (1997)

    Article  PubMed  CAS  Google Scholar 

  15. Caudevilla, C; Serra, D.; Miliar, A.; Codony, C; Asins, G.; Bach, M.; Hegardt, F.G.: Processing of carnitine octanoyltransferase pre-mRNAs by cis and trans-splicing. Adv. Exp. Med. Biol., 466, 95–102 (1999)

    Article  PubMed  CAS  Google Scholar 

  16. Ferdinandusse, S.; Mulders, J.; IJlst, L.; Denis, S.; Dacremont, G.; Waterham, H.R.; Wanders, R.J.A.: Molecular cloning and expression of human carni-tine octanoyltransferase: Evidence for its role in the peroxisomal β-oxida-tion of branched-chain fatty acids. Biochem. Biophys. Res. Commun., 263, 213–218 (1999)

    Article  PubMed  CAS  Google Scholar 

  17. Ramsay, R.R.; Gandour, R.D.: Selective modulation of carnitine long-chain acyltransferase activities: Kinetics, inhibitors, and active sites of COT and CPT-II. Adv. Exp. Med. Biol., 466, 103–109 (1999)

    PubMed  CAS  Google Scholar 

  18. Morillas, M.; Clotet, J.; Rubi, B.; Serra, D.; Arino, J.; Hegardt, F.G.; Asins, G.: Inhibition by etomoxir of rat liver carnitine octanoyltransferase is produced through the co-ordinate interaction with two histidine residues. Biochem. J., 351, 495–502 (2000)

    Article  PubMed  CAS  Google Scholar 

  19. Hegardt, F.G.; Bach, M.; Asins, G.; Caudevilla, C; Morillas, M.; Codony, C; Serra, D.: Post-transcriptional regulation of rat carnitine octanoyltransferase. Biochem. Soc. Trans., 29, 316–320 (2001)

    Article  PubMed  CAS  Google Scholar 

  20. Morillas, M.; Gomez-Puertas, P.; Roca, R.; Serra, D.; Asins, G.; Valencia, A.; Hegardt, F.G.: Structural model of the catalytic core of carnitine palmitoyl-transferase I and carnitine octanoyltransferase (COT). Mutation of CPT 1 histidine 473 and alanine 381 and COT alanine 238 impairs the catalytic activity. J. Biol. Chem., 276, 45001–45008 (2001)

    Article  PubMed  CAS  Google Scholar 

  21. Morillas, M.; Gomez-Puertas, P.; Rubi, B.; Clotet, J.; Arino, J.; Valencia, A.; Hegardt, F.G.; Serra, D.; Asins, G.: Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I. Mutational analysis of a malonyl-CoA affinity domain. J. Biol. Chem., 277, 11473–11480 (2002)

    Article  PubMed  CAS  Google Scholar 

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(2006). Carnitine O-octanoyltransferase. In: Schomburg, D., Schomburg, I., Chang, A. (eds) Springer Handbook of Enzymes. Springer Handbook of Enzymes, vol 30. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-37717-4_78

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