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The Role of Histone Modifications in Epigenetic Transitions During Normal and Perturbed Development

  • Conference paper
Book cover The Histone Code and Beyond

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 57))

Abstract

Epigenetic mechanisms control eukaryotic development beyond DNA-stored information. DNA methylation, histone modifications and variants, nucleosome remodeling and noncoding RNAs all contribute to the dynamic make-up of chromatin under distinct developmental options. In particular, the great diversity of covalent histone tail modifications has been proposed to be ideally suited for imparting epigenetic information. While most of the histone tail modifications represent transient marks at transcriptionally permissive chromatin, some modifications appear more robust at silent chromatin regions, where they index repressive epigenetic states with functions also outside transcriptional regulation. Under-representation of repressive histone marks could be indicative of epigenetic plasticity in stem, young and tumor cells, while committed and senescent (old) cells often display increased levels of these more stable modifications. Here, we discuss profiles of normal and aberrant histone lysine methylation patterns, as they occur during the transition of an embryonic to a differentiated cell or in controlled self-renewal vs pro-neoplastic or metastatic conditions. Elucidating these histone modification patterns promises to have important implications for novel advances in stem cell research, nuclear reprogramming and cancer, and may offer novel targets for the combat of tumor cells, potentially leading to new diagnostic and therapeutic avenues in human biology and disease.

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Authors and Affiliations

  1. Research Institute of Molecular Pathology (IMP), The Vienna Biocenter, Dr. Bohrgasse 7, 1030, Vienna, Austria

    S. Kubicek, G. Schotta, R. Sengupta, A. Kohlmaier, L. Perez-Burgos, Y. Linderson, J. H. A. Martens, R. J. O’Sullivan, B. D. Fodor, M. Yonezawa & T. Jenuwein

  2. The Rockefeller University, 1230 York Avenue, New York, NY, 10021, USA

    M. Lachner

  3. Friedrich Miescher Insitute for Biomedical Research (FMI), Novartis Research Foundation, Maulbeerstrsse 66, CH-4058, Basel, Switzerland

    A. H. F. M. Peters

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  1. S. Kubicek
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  2. G. Schotta
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  3. M. Lachner
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  4. R. Sengupta
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  5. A. Kohlmaier
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  7. Y. Linderson
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  8. J. H. A. Martens
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  9. R. J. O’Sullivan
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  10. B. D. Fodor
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  12. A. H. F. M. Peters
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  13. T. Jenuwein
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Editors and Affiliations

  1. Gene Expression and Regulation Program, The Wistar Institute, 3601 Spruce Street, Room 201, PA, 19104, Philadelphia, USA

    S. L. Berger

  2. CRBA Oncology, Nihon Schering, Kobe, Japan

    O. Nakanishi

  3. CRBA Oncology, Schering AG, Müllerstr. 178, 13342, Berlin, Germany

    B. Haendler

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Kubicek, S. et al. (2006). The Role of Histone Modifications in Epigenetic Transitions During Normal and Perturbed Development. In: Berger, S.L., Nakanishi, O., Haendler, B. (eds) The Histone Code and Beyond. Ernst Schering Research Foundation Workshop, vol 57. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-37633-X_1

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  • DOI: https://doi.org/10.1007/3-540-37633-X_1

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