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Zusammenfassung

Nur bei etwa 60% der Patienten kommen in den Blutbildern — und dann meist wenige — „hairy cells“ vor. Sie zeichnen sich durch die namensgebenden langen Ausläufer des meist weiten und unruhig gefärbten Zytoplasmas aus. Zusammen mit dem eher lockeren und oft weit gebuchteten Kern sind Hairy cells meist ohne weiteres zuzuordnen. Nukleolen sind nur sehr diskret erkennbar. Anisozytose, Monozytopenie und niedrige Retikulozytenzahlen stützen die Vermutung einer Haarzell-Leukämie (HZL).

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Literatur

  • Damasio E, Carella AM (ICGHCL) (1995) Treatment of HCL with 2-chlorodeoxyadenosine (2-CDA) in two different schedules. Blood (suppl):3230

    Google Scholar 

  • Dearden CE, Matutes E, Hilditch BL et al (1999) Long-term follow-up of patients with hairy cell leukaemia after treatment with pentostatin or cladribine Br J Haematol 106:515–519

    Article  PubMed  CAS  Google Scholar 

  • Flinn IW, Kopecky KJ, Foucar MK et al (2000) Long-term follow-up of remissions duration, mortality, and second malignancies in hairy cell leukaemia patients with pentostatin. Blood 96:2981–2986

    PubMed  CAS  Google Scholar 

  • Hagberg H, Lundholm L (2001) Rituximab, a clinical anti-CD20 monoclonal antibody in the treatment of hairy cell leukemia. Br J Haematol 115:609–611

    Article  PubMed  CAS  Google Scholar 

  • Hakimian D, Tallman MS, Kiley C, Peterson L (1993) Detection of minimal residual disease by immunostaining of bone marrow biopsies after 2-chlorodeoxyadenosine for hairy cell leukemia. Blood 82:1798–1802

    PubMed  CAS  Google Scholar 

  • Hoffmann MA, Janson D, Rose E et al (1997) Treatment of hairy cell leukemia with cladribine: response, toxicity and long-term follow-up. J Clin Oncol 15:1138–1142

    Google Scholar 

  • Kreitman RJ, Wilson WH, Bergeron K et al (2001) Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia. N Eng J Med 345:241–247

    Article  CAS  Google Scholar 

  • Meyer U, Strehl J, Gorschlüter M et al (2003) Advances in the treatment of hairy cell leukemia. Lancet Oncol 4:86–94

    Article  Google Scholar 

  • Nielsen B, Braide I (1992) Three years continuous low-dose interferon-alpha treatment of hairy-cell leukemia: Evaluation of response and maintenance dose. Eur J Haematol 49:174–179

    Article  PubMed  CAS  Google Scholar 

  • Saven A, Piro LD: Complete remissions in hairy cell leukemia with 2-chlorodeoxyadenosine after failure with 2′-deoxycoformycin. Ann Intern Med 119:278–283

    Google Scholar 

  • Seymour JF, Talpaz M, Kurzrock R (1995) Splenectomized patients have more rapid recovery of CD4+ lymphocytes following deoxycoformycin: Long-term follow-up of patients with hairy cell leukemia resistant to interferon. Blood (suppl):1391

    Google Scholar 

  • Smith II JW, Longo DL, Urba WJ et al (1991) Prolonged, continuous treatment of hairy cell leukemia patients with recombinant interferon-α 2a. Blood 78:1664–1671

    PubMed  Google Scholar 

  • Thaler J, Grunewald K, Gattringer C et al (1993) Long-term follow-up of patients with hairy cell leukemia treated with pentostatin: lymphocyte subpopulations and residual bone marrow infiltration. Br J Haematol 84:75–82

    Article  PubMed  CAS  Google Scholar 

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© 2006 Springer Medizin Verlag Heidelberg

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Pralle, H., Schmidt-Wolf, I. (2006). Haarzell-Leukämie. In: Schmoll, HJ., Höffken, K., Possinger, K. (eds) Kompendium Internistische Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-31303-6_174

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  • DOI: https://doi.org/10.1007/3-540-31303-6_174

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-20657-6

  • Online ISBN: 978-3-540-31303-8

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