Definition
Caspase 3 is an apoptosis-related cysteine protease, involved in the activation cascade of caspases that is responsible for apoptosis execution. At the onset it proteolytically cleaves poly(ADP-ribose) polymerase (Parp). It also cleaves and activates caspase 6, caspase 7 and caspase 9. It is a cytoplasmic protein that is widely expressed and forms a heterodimer of 17 kD (p17) and 12 kD (p12). The gene maps to 4q33.
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© 2001 Springer-Verlag
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(2001). Caspase 3. In: Schwab, M. (eds) Encyclopedic Reference of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-30683-8_241
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DOI: https://doi.org/10.1007/3-540-30683-8_241
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-66527-4
Online ISBN: 978-3-540-30683-2
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