Skip to main content
SpringerLink
Log in

Staphylococcus aureus and Atopic Eczema

  • Chapter
Handbook of Atopic Eczema

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 199.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Leyden JJ, Marples RR, Kligman AM (1974) Staphylococcus aureus in the lesions of atopic dermatitis. Br J Dermatol 90:525–530

    CAS  PubMed  Google Scholar 

  2. Mempel M, Lina G, Hojka M, Schnopp C, Seidl HP, Schafer T, Ring J, Vandenesch F, Abeck D (2003) High prevalence of superantigens associated with the egc locus in Staphylococcus aureus isolates from patients with atopic eczema. Eur J Clin Microbiol Infect Dis 22:306–309

    CAS  PubMed  Google Scholar 

  3. Zeisler J (1885) Note on the antiparasitic treatment of eczema. J Cutan Genito-Urinary Dis 13:507–511

    Google Scholar 

  4. Dahl, MV (1983) Staphylococcus aureus and atopic dermatitis. Arch Dermatol 119:840–846

    CAS  PubMed  Google Scholar 

  5. Aly R, Maibach HI, Shinefield HR (1977) Microbial flora of atopic dermatitis. Arch Dermatol 113:780–782

    Article  CAS  PubMed  Google Scholar 

  6. Hoeger PH, Lenz W, Boutonnier A, Fournier JM (1992) Staphylococcal skin colonization in children with atopic dermatitis: prevalence, persistence, transmission of toxigenic and nontoxigenic strains. J Infect Dis 165:1064–1068

    CAS  PubMed  Google Scholar 

  7. Leung D (2002) Role of Staphylococcus aureus in atopic dermatitis. In: Bieber TL (ed) Atopic dermatitis. Vol. 1. Marcel Dekker, New York, p 401–418

    Google Scholar 

  8. Mempel M, Schmidt T, Weidinger S, Schnopp C, Foster T, Ring J, Abeck D (1998) Role of Staphylococcus aureus surface-associated proteins in the attachment to cultured HaCaT keratinocytes in a new adhesion assay. J Invest Dermatol 111:452–456

    Article  CAS  PubMed  Google Scholar 

  9. Cho, SH, Strickland I, Boguniewic Mz, Leung DY (2001) Fibronectin and fibrinogen contribute to the enhanced binding of Staphylococcus aureus to atopic skin. J Allergy Clin Immunol 108:269–274

    CAS  PubMed  Google Scholar 

  10. Cho, SH, Strickland I, Tomkinson A, Fehringer AP, Gelfand EW, Leung DY (2001) Preferential binding of Staphylococcus aureus to skin sites of Th2-mediated inflammation in a murine model. J Invest Dermatol 116:658–663

    Article  CAS  PubMed  Google Scholar 

  11. Postlethwaite AE, Holness MA, Katai H, Raghow R (1992) Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin 4. J Clin Invest 90:1479–1485

    CAS  PubMed  Google Scholar 

  12. Wann ER, Gurusiddappa S, Hook M (2000) The fibronectin-binding MSCRAMM FnbpA of Staphylococcus aureus is a bifunctional protein that also binds to fibrinogen. J Biol Chem 275:13863–13871

    Article  CAS  PubMed  Google Scholar 

  13. Mempel M, Schnopp C, Hojka M, Fesq H, Weidinger S, Schaller M, Korting HC, Ring J, Abeck D (2002) Invasion of human keratinocytes by Staphylococcus aureus and intracellular bacterial persistence represent haemolysin-independent virulence mechanisms that are followed by features of necrotic and apoptotic keratinocyte cell death. Br J Dermatol 146:943–951

    Article  CAS  PubMed  Google Scholar 

  14. Walev I, Martin E, Jonas D, Mohamadzadeh M, Muller-Klieser W, Kunz L, Bhakdi S (1993) Staphylococcal alphatoxin kills human keratinocytes by permeabilizing the plasma membrane for monovalentions. Infect Immun 61:4972–4979

    CAS  PubMed  Google Scholar 

  15. Leung DY, Gately M, Trumble A, Ferguson B-Darnell, Schlievert PM, Picker LJ (1995) Bacterial superantigens induce T cell expression of the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen, via stimulation of interleukin 12 production. J Exp Med 181:747–753

    CAS  PubMed  Google Scholar 

  16. Leung, DY, Harbeck R, Bina P, Reiser RF, Yang E, Norris DA, Hanifin JM, Sampson HA (1993) Presence of IgE antibodies to staphylococcal exotoxins on the skin of patients with atopic dermatitis. Evidence for a new group of allergens. J Clin Invest 92:1374–1380

    CAS  PubMed  Google Scholar 

  17. Bunikowski R, Mielke M, Skarabis H, Herz U, Bergmann RL, Wahn U, Renz H (1999) Prevalence and role of serum IgE antibodies to the Staphylococcus aureus-derived superantigens SEA and SEB in children with atopic dermatitis. J Allergy Clin Immunol 103:119–124

    Article  CAS  PubMed  Google Scholar 

  18. Nomura I, Tanaka K, Tomita H, Katsunuma T, Ohya Y, Ikeda N, Takeda T, Saito H, Akasawa A (1999) Evaluation of the staphylococcal exotoxins and their specific IgE in childhood atopic dermatitis. J Allergy Clin Immunol 104: 441–446

    Article  CAS  PubMed  Google Scholar 

  19. Lin YT, Shau WY, Wang LF, Yang YH, Hwang YW, Tsai MJ, Tsao PN, Chiang BL (2000) Comparison of serum specific IgE antibodies to staphylococcal enterotoxins between atopic children with and without atopic dermatitis. Allergy 55:641–646

    Article  CAS  PubMed  Google Scholar 

  20. Strange P, Skov L, Lisby S, Nielsen PL, Baadsgaard O (1996) Staphylococcal enterotoxin B applied on intact normal and intact atopic skin induces dermatitis. Arch Dermatol 132: 27–33

    Article  CAS  PubMed  Google Scholar 

  21. Skov L, Olsen JV, Giorno R, Schlievert PM, Baadsgaard O, Leung DY (2000) Application of Staphylococcal enterotoxin B on normal and atopic skin induces up-regulation of T cells by a superantigen-mediated mechanism. J Allergy Clin Immunol 105:820–826

    Article  CAS  PubMed  Google Scholar 

  22. Saloga J, Leung DY, Reardon C, Giorno RC, Born W, Gelfand EW (1996) Cutaneous exposure to the superantigen staphylococcal enterotoxin B elicits a T-cell-dependent inflammatory response. J Invest Dermatol 106:982–988

    Article  CAS  PubMed  Google Scholar 

  23. Neuber K, Loliger C, Kohler I, Ring J (1996) Preferential expression of T-cell receptor V beta-chains in atopic eczema. Acta Derm Venereol 76:214–218

    CAS  PubMed  Google Scholar 

  24. Hofer, MF, Harbeck RJ, Schlievert PM, Leung DY (1999) Staphylococcal toxins augment specific IgE responses by atopic patients exposed to allergen. J Invest Dermatol 112: 171–176

    Article  CAS  PubMed  Google Scholar 

  25. McFadden JP, Noble WC, Camp RD (1993) Superantigenic exotoxin-secreting potential of staphylococci isolated from atopic eczematous skin. Br J Dermatol 128:631–632

    CAS  PubMed  Google Scholar 

  26. Jappe U, Heuck D, Witte W, Gollnick H (1998) Superantigen production by Staphylococcus aureus in atopic dermatitis: no more than a coincidence? J Invest Dermatol 110: 844–846

    CAS  PubMed  Google Scholar 

  27. Peng HL, Novick RP, Kreiswirth B, Kornblum J, Schlievert P (1988) Cloning, characterization, sequencing of an accessory gene regulator (agr) in Staphylococcus aureus. J Bacteriol 170:4365–4372

    CAS  PubMed  Google Scholar 

  28. Smeltzer MS, Hart ME, Iandolo JJ (1993) Phenotypic characterization of xpr, a global regulator of extracellular virulence factors in Staphylococcus aureus. Infect Immun 61: 919–925

    CAS  PubMed  Google Scholar 

  29. Cheung AL, and SJ Projan (1994) Cloning and sequencing of sarA of Staphylococcus aureus, a gene required for the expression of agr. J Bacteriol 176:4168–4172

    CAS  PubMed  Google Scholar 

  30. Jarraud S, Peyrat MA, Lim A, Tristan A, Bes M, Mougel C, Etienne J, Vandenesch F, Bonneville M, Lina G (2001) egc, a highly prevalent operon of enterotoxin gene, forms a putative nursery of superantigens in Staphylococcus aureus. J Immunol 166:669–677

    CAS  PubMed  Google Scholar 

  31. Mempel M, Voelcker V, Köllisch G, Plank C, Rad R, Gerhard M, Schnopp C, Fraunberge Pr, Walli AK, Ring J, Abeck D, Ollert M (2003) Toll-like receptor expression in human keratinocytes: nuclear factor kappaB controlled gene activation by Staphylococcus aureus is toll-like receptor 2 but not toll-like receptor 4 or platelet activating factor receptor dependent. J Invest Dermatol 121:1389–1396

    Article  CAS  PubMed  Google Scholar 

  32. Curry JL, Qin JZ, Bonish B, Carrick R, Bacon P, Panella J, Robinson J, Nickoloff BJ (2003) Innate immune-related receptors in normal and psoriatic skin. Arch Pathol Lab Med 127:178–186

    CAS  PubMed  Google Scholar 

  33. Frohm M, Agerberth B, Ahangari G, Stahle M-Backdahl, Liden S, Wigzell H, Gudmundsso GHn (1997) The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders. J Biol Chem 272:15258–15263

    Article  CAS  PubMed  Google Scholar 

  34. Harder J, Bartels J, Christophers E, Schroder JM (1997) A peptide antibiotic from human skin. Nature 387:861

    Article  CAS  PubMed  Google Scholar 

  35. Harder J, Siebert R, Zhang Y, Matthiesen P, Christophers E, Schlegelberger B, Schroder JM (1997) Mapping of the gene encoding human beta-defensin-2 (DEFB2) to chromosome region 8p22-p23.1. Genomics 46:472–475

    Article  CAS  PubMed  Google Scholar 

  36. Harder J, Bartels J, Christophers E, Schroder JM (2001) Isolation and characterization of human beta-defensin-3, a novel human inducible peptide antibiotic. J Biol Chem 276:5707–5713

    Article  CAS  PubMed  Google Scholar 

  37. Stolzenberg ED, Anderson GM, Ackermann MR, Whitlock RH, Zasloff M (1997) Epithelial antibiotic induced in states of disease. Proc Natl Acad Sci U S A 94:8686–8690

    Article  CAS  PubMed  Google Scholar 

  38. Hamid Q, Boguniewicz M, Leung DY (1994) Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis. J Clin Invest 94:870–876

    CAS  PubMed  Google Scholar 

  39. Ong PY, Ohtake T, Brandt C, Strickland I, Boguniewicz M, Ganz T, Gallo RL, Leung DY (2002) Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med 347:1151–1160

    Article  CAS  PubMed  Google Scholar 

  40. Nomura I, Goleva E, Howell MD, Hamid QA, Ong PY, Hall CF, Darst MA, Gao B, Boguniewicz M, Travers JB, Leung DY (2003) Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes. J Immunol 171:3262–3269

    CAS  PubMed  Google Scholar 

Download references

Authors
  1. M. Mempel
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, Technische Universität München, Biedersteiner Straße 29, 80802, München, Germany

    Johannes Ring

  2. Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität, Frauenlobstraße 9-11, 80337, München, Germany

    Bernhard Przybilla

  3. Klinik und Poliklinik für Dermatologie, Heinrich-Heine-Universität, Moorenstraße 5, 40225, Düsseldorf, Germany

    Thomas Ruzicka

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Mempel, M. (2006). Staphylococcus aureus and Atopic Eczema. In: Ring, J., Przybilla, B., Ruzicka, T. (eds) Handbook of Atopic Eczema. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29856-8_42

Download citation

  • DOI: https://doi.org/10.1007/3-540-29856-8_42

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-23133-2

  • Online ISBN: 978-3-540-29856-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation