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Histopathologic and Ultrastructural Aspects of Atopic Eczema

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Handbook of Atopic Eczema

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References

  1. Agner T (1991) Skin susceptibility in uninvolved skin of hand eczema patients and healthy controls. Br J Dermatol 125:140–146

    CAS  PubMed  Google Scholar 

  2. Agner T (1991) Susceptibility of atopic dermatitis patients to irritant dermatitis caused by sodium lauryl sulphate. Acta Derm Venereol (Stockh) 71:296–300

    CAS  Google Scholar 

  3. Al-Jaberi H, Marks R (1984) Studies of the clinically uninvolved skin in patients with dermatitis. Br J Dermatol 111:437–443

    CAS  PubMed  Google Scholar 

  4. D’Amico G, Bianchi G, Bernasconi S et al (1998) Adhesion, transendothelial migration, and reverse transmigration of in vitro cultured dendritic cells. Blood 92:207–214

    CAS  PubMed  Google Scholar 

  5. Bleck O, Abeck D, Ring J et al (1999) Two ceramide subfractions detectable in Cer(AS) position by HPTLC in skin surface lipids of non-lesional skin of atopic eczema J Invest Dermatol 113:894 900

    Article  PubMed  Google Scholar 

  6. DiNardo A, Wertz P, Giannetti A et al (1998) Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Derm Venereol 78:27–30

    CAS  Google Scholar 

  7. Elias PM, Feingold KR, Fartasch M (2005) The epidermal lamellar body as a multifunctional secretory organelle. In: Elias PM, Feingold KR (ed) Skin barrier function. (in press)

    Google Scholar 

  8. Fartasch M (1997) The epidermal barrier in disorders of the skin. Microsc Res Techniq 38:361–372

    CAS  Google Scholar 

  9. Fartasch M (2004) The epidermal lamellar body: a fascinating secretory organelle. J Invest Dermatol 122:XI–XII

    Article  CAS  PubMed  Google Scholar 

  10. Fartasch M (2005) Atopic dermatitis and other skin disease. In: Maibach F (ed) Bioengineering of the skin: water and stratum corneum, 2, CRC Press, Boca Raton, pp 160–169

    Google Scholar 

  11. Fartasch M, Bassukas ID, Diepgen TL (1992) Disturbed extruding mechanism of lamellar bodies in dry noneczematous skin of atopics. Br J Dermatol 127:221

    CAS  PubMed  Google Scholar 

  12. Fartasch M, Diepgen TL, Hornstein OP (1989) Atopic dermatitis — ichthyosis vulgaris — hyperlinear palms — an ultrastructural study. Dermatologica 178:202–205

    CAS  PubMed  Google Scholar 

  13. Fartasch M, Bassukas ID, Diepgen TL (1993) Structural relationship between epidermal lipids, lamellar bodies and desmosomes in human epidermis: an ultrastructural study Br J Dermatol 128:1–9

    CAS  PubMed  Google Scholar 

  14. Finlay AY, Nicholls S, King CS, Marks R (1980) The dry non-eczematous skin associated with atopic eczema. Br J Dermatol 102:249–256

    Google Scholar 

  15. Frödin T, Helander P, Molin L, Skogh M (1988) Hydration of human stratum corneum studied in vivo by optothermal infrared spectrometry, electrical capacitance measurement, and evaporimetry Acta Derm Venereol (Stockh) 68:461–467

    Google Scholar 

  16. Hamid Q, Boguniewicz M, Leung DY (1994) Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis. J Clin Invest 94:870–876

    CAS  PubMed  Google Scholar 

  17. Hara J, Higuchi K, Okamoto R et al (2000) High-expression of sphingomyelin deacylase is an important determinant of ceramide deficiency leading to barrier disruption in atopic dermatitis. J Invest Dermatol 115:406–413

    Article  CAS  PubMed  Google Scholar 

  18. Hou SYE, Mitra AK, White SH, Menon GK, Ghadially R, Elias PM (1991) Membrane structures in normal and essential fatty acid-deficient stratum corneum: characterization by ruthenium tetroxide staining and X-ray diffraction J Invest Dermatol 96:215–

    CAS  PubMed  Google Scholar 

  19. Imokawa G, Abe A, Jin K, Higaki Y, Kawashima M, Hidano A (1991) Decreased levels of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin? J Invest Dermatol 96:523–526

    CAS  PubMed  Google Scholar 

  20. Järvikallio A, Harvima IT, Naukkarinen A (2003) Mast cells, nerves and neuropeptides in atopic dermatitis and nummular eczema. Arch Dermatol Res 295:2–7

    PubMed  Google Scholar 

  21. Jensen JM, Folster-Holst R, Baranowsky A, Schunck M, Winoto-Morbach S, Neumann C, Schutze S, Proksch E (2004) Impaired sphingomyelinase activity and epidermal differentiation in atopic dermatitis. J Invest Dermatol 122: 1423–1431

    Article  CAS  PubMed  Google Scholar 

  22. Kiekens RCM, Thepen T, Oosting AI,.Bihari IC, Van de Winkel JGJ, Bruijnzeel-Koomen CAFM, Knol EFL (2001) Heterogeneity within tissue-specific macrophage and dendritic cell populations during cutaneous inflammation in atopic dermatitis. Br J Dermatol 145:957–965

    Article  CAS  PubMed  Google Scholar 

  23. Leung DYM, Boguniewicz M, Howell MD, Nomura I, Hamid QA (2004) New insights into atopic dermatitis. J Cin Invest 113:651–657

    CAS  Google Scholar 

  24. Léveque JL, Grove G, Rigal de J et al (1987) Biophysical characterization of facial dry skin J Soc Cosmet Chem 82: 171–177

    Google Scholar 

  25. Lever WF, Schaumberg-Lever G (eds) (1990) Histopathology of the skin. JB Lippincott, Philadelphia

    Google Scholar 

  26. Loffler H, Effendy I (1999) Skin susceptibility of atopic individuals. Contact Dermatitis 40:239–242

    CAS  PubMed  Google Scholar 

  27. Madison KC, Swartzendruber DC, Wertz PW, Downing DT (1987) Presence of intact intercellular lipid lamellae in the upper layers of the stratum corneum. J Invest Dermatol 88:714–718

    Article  CAS  PubMed  Google Scholar 

  28. Marks R, Nicholls S, King CS (1981) Studies on isolated corneocytes. Int J Cosmet Sci 3:251–256

    Google Scholar 

  29. Matsumoto M, Umemoto M, Sugiura H et al (1999) Difference in ceramide composition between “dry” and “normal” skin in patients with atopic dermatitis. Acta Derm Venereol 79:246–247

    CAS  PubMed  Google Scholar 

  30. Melnik B, Hollmann J, Hofmann U, Yuh M.-S, Plewig G (1990) Lipid composition of outer stratum corneum and nails in atopic and control subjects. Arch Dermatol Res 282:549–551

    Article  CAS  PubMed  Google Scholar 

  31. Murahata RJ, Crowe DM, Roheim JR (1986) The use of transepidermal water loss to measure and predict the irritation response to surfactants. Int J Cosmet Sci 8:225–228

    CAS  Google Scholar 

  32. Murata Y, Ogata J, Higaki Y et al (1996) Abnormal expression of sphingomyelin acylase in atopic dermatitis: an etiologic factor for ceramide deficiency? J Invest Dermatol 106:1242–1249

    Article  CAS  PubMed  Google Scholar 

  33. Novak N, Kraft S, Bieber T (2003) Unraveling the mission of Fc-epsilon-RI on antigen-presenting cells. J Allergy Clin Immunol 111:38–44

    Article  CAS  PubMed  Google Scholar 

  34. Ohnishi Y, Okino N, Ito M, Imayama S (1999) Ceramidase activity in bacterial skin ora as a possible cause of ceramide deficiency in atopic dermatitis. Clin Diagn Lab Immunol 6:101–104

    CAS  PubMed  Google Scholar 

  35. Piérard GE (1989) What do youmean by dry skin? Dermatologica, 179:1–2

    PubMed  Google Scholar 

  36. Pilgram GSK, Vissers DCJ, Meulen van der H, Pavel S, Lavrijsen SPM, Bouwstra JA, Korten HK (2001) Aberrant lipid organization in stratum corneum of patients with atopic dermatitis and lamellar ichthyosis. J Invest Dermatol 117:710–712

    Article  CAS  PubMed  Google Scholar 

  37. Proksch E, Elias P. M, Feingold KR (1990) Regulation of 3-hydroxy-3-methyl-glutaryl-coenzyme a reductase activity in murine epidermis J Clin Invest 85:874–882

    CAS  PubMed  Google Scholar 

  38. Sakurai K, Sugiura H, Matsumoto M et al (2002) Occurrence of patchy parakeratosis in normal-appearing skin in patients with active atopic dermatitis and in patients with healed atopic dermatitis: a cause of impaired barrier function of the atopic skin. J Dermatol Sci 30:37–42

    Article  PubMed  Google Scholar 

  39. Schäfer L, Kragballe K (1991) Abnormalities in epidermal lipidmetabolismin patients with atopic dermatitis J Invest Dermatol 96:10–15

    PubMed  Google Scholar 

  40. Semper AE, Heron K, Woollard AC, Kochan JP, Friedmann PS, Church MK, Reischl IG (2003) Surface expression of Fc epsilon RI on Langerhans cells of clinically uninvolved skin is associatedwith disease activity in atopic dermatitis, allergic asthma, and rhinitis. J Allergy Clin Immunol 112: 411–419

    Article  CAS  PubMed  Google Scholar 

  41. Swartzendruber DC, Wertz PW, Madison KC, Downing DT (1987) Evidence that the corneocyte has a chemically bound lipid envelope. J Invest Dermatol 88:709–713

    Article  CAS  PubMed  Google Scholar 

  42. Uehara M, Hayashi S (1981) Hyperlinear palms. Arch Dermatol 117:490–491

    CAS  PubMed  Google Scholar 

  43. Uehara M, Miyauchi H (1984) Themorphologic characteristics of dry skin in atopic dermatitis. Arch Dermatol 120:1186–1190

    CAS  PubMed  Google Scholar 

  44. Watanabe M, Tagami T, Horii I, Takahashi M, Kligman AM (1991) Functional analyses of the superficial stratum corneum in atopic xerosis. Arch Dermatol 127:1689–1692

    Article  CAS  PubMed  Google Scholar 

  45. Yamamoto A, Serizawa M, Ito M, Sato Y (1991) Stratum corneum lipid abnormalities in atopic dermatitis. Arch Dermatol Res 283:219–223

    Article  CAS  PubMed  Google Scholar 

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Authors
  1. M. Fartasch
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Editor information

Editors and Affiliations

  1. Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, Technische Universität München, Biedersteiner Straße 29, 80802, München, Germany

    Johannes Ring

  2. Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität, Frauenlobstraße 9-11, 80337, München, Germany

    Bernhard Przybilla

  3. Klinik und Poliklinik für Dermatologie, Heinrich-Heine-Universität, Moorenstraße 5, 40225, Düsseldorf, Germany

    Thomas Ruzicka

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© 2006 Springer-Verlag Berlin Heidelberg

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Fartasch, M. (2006). Histopathologic and Ultrastructural Aspects of Atopic Eczema. In: Ring, J., Przybilla, B., Ruzicka, T. (eds) Handbook of Atopic Eczema. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29856-8_20

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  • DOI: https://doi.org/10.1007/3-540-29856-8_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-23133-2

  • Online ISBN: 978-3-540-29856-4

  • eBook Packages: MedicineMedicine (R0)

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