Synonyms
CC chemokine receptor-5.
Definition
A membrane protein that binds members of the CC chemokine family, including RANTES (CCL5) and macrophage inflammatory protein-1α/β.
Full Text
Expressed on activated Th1 T-lymphocytes, dendritic cells, monocytes, and NK cells, CCR5 is a membrane receptor for the CC chemokines RANTES (CCL5), macrophage inflammatory protein-1α (MIP-1α), and MIP-1β. Increased expression of CCR5 is observed on CNS lymphocytes in patients with inflammatory demyelinating disease. A mutation in CCR5 with an allele frequency of approximately 20% in Caucasians rendering the receptor inactive (Δ32) is associated with decreased severity of CNS inflammatory diseases including multiple sclerosis and also is protective against infection with HIV-1.
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References
Balashov KE, Rottman JB, Weiner HL, Hancock WW (1999) CCR5+ and CXCR3+ are increased in multiple sclerosis and their ligands MIP-1alfa and IP-10 are expressed in demyelinating brain lesions. Proc Nat Acad Sci 96:6873–8
Luster AD (1998) Chemokines – Chemotactic cytokines that mediate inflammation. N Engl J Med 338:436
Qin S, Rottman JB, Myers P, et al (1998) The chemokine receptors CXCR3 and CCR5 mark subsets of T-cells associated with certain inflammatory reactions. J Clin Invest 101:746
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© 2004 Springer-Verlag
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(2004). CCR5. In: Moreland, L.W. (eds) Rheumatology and Immunology Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29662-X_577
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DOI: https://doi.org/10.1007/3-540-29662-X_577
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-20625-5
Online ISBN: 978-3-540-29662-1
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