Synonyms
Divalproex sodium.
Trade Names
Depacon; Depakene; Depakote.
Class and Category
Anticonvulsants.
Indications
Absence seizure, bipolar disorder, mania, migraine prophylaxis, myoclonic seizures, partial seiazure, tonic-clonic seizures.
Dosage
Initial dose 10–15 mg/kg/day; maximum of 60 mg/kg.day.
Contraindications
Encephalopathy, hepatic disease, pancreatitis.
Adverse Reactions
Hepatotoxicity, pancreatitis, hyponatremia, bone marrow suppression, hyperammonemia, Stevens-Johnson syndrome, fetal abnormalities.
Drug Interactions
Aspirin, nonsteroidal antiinflammaotry drugs, warfarin — increased risk of bleeding related to valproic acid's antiplatelet effect; Temololomide — increased risk of myelosuppression; Ethanol — central nervous system suppression; Lamotrigine — increased risk of hepatic toxicity; Carbamazepine, cimetidine, clarithromycin, lopinavir, mefloquine — possible increased valproic acid levels.
Mechanism of Action
Presumably increases brain concentrations of gamma-amino...
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References
McNamar JD (2001) Drugs effective in the therapy of the epilepsies. In: Hardman JG, Limbird LE (eds) Pharmacological basis of therapeutics. McGraw-Hill, New York, pp 521–47
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© 2004 Springer-Verlag
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(2004). Valproic acid. In: Moreland, L.W. (eds) Rheumatology and Immunology Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-29662-X_2697
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DOI: https://doi.org/10.1007/3-540-29662-X_2697
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-20625-5
Online ISBN: 978-3-540-29662-1
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