Conclusions
The application of modern MRI techniques to the assessment of MS patients has considerably improved our understanding of MS pathophysiology and has provided new objective metrics that might be useful to monitor disease evolution, either in natural history studies or in treatment trials. However, none of the quantitative MR-based techniques considered, taken in isolation, is able to provide a complete picture of the complexity of the MS process and this should call for the definition of aggregates of MR quantities, thought to reflect different aspects of MS pathology, to improve our ability to monitor the disease. At present, longitudinal natural history data collected in large samples of MS patients using structural, metabolic and functional MR techniques are needed to gain additional insight into MS pathobiology and on the actual value of modern MR technologies in the management of MS.
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Filippi, M., Rocca, M.A. (2005). Multiple Sclerosis: Other MR Techniques. In: Filippi, M., De Stefano, N., Dousset, V., McGowan, J.C. (eds) MR Imaging in White Matter Diseases of the Brain and Spinal Cord. Medical Radiology Diagnostic Imaging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27644-0_15
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