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Microdialysis in traumatic brain injury — methodology and pathophysiology

  • Conference paper
Intracranial Pressure and Brain Monitoring XII

Part of the book series: Acta Neurochirurgica Supplementum ((NEUROCHIRURGICA,volume 95))

Summary

The application of clinical microdialysis to monitor changes in cerebral extracellular chemistry is now well established in several neurosurgical units worldwide. In neuro-intensive care the technique has been predominantly applied to patients with traumatic brain injury and subarachnoid haemorrhage. There is no doubt that microdialysis has increased and continues to increase our understanding of the pathophysiology of these conditions. Current studies are addressing the potential role of microdialysis as a clinical monitoring technique assisting in the management of patients on an intention to treat basis. This involves establishing the relationship between microdialysis and outcome, and the effect of therapeutic manoeuvres on the chemistry. This manuscript describes the place of microdialysis in traumatic brain injury in terms of the fundamental principles, methodology, pathophysiology and clinical application.

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Author information

Authors and Affiliations

  1. Academic Department of Neurosurgery and Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke’s Hospital, UK

    P. J. Hutchinson

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  1. P. J. Hutchinson
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Correspondence to P. J. Hutchinson .

Editor information

Editors and Affiliations

  1. Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China

    Wai S. Poon , Matthew T. V. Chan , Keith Y. C. Goh , Joseph M. K. Lam  & Stephanie C. P. Ng , , ,  & 

  2. Medical College of Virginia Commonwealth University, Virginia, USA

    Anthony Marmarou

  3. Academisch Ziekenhuis Dijkzigt, Erasmus University Rotterdam, Rotterdam, The Netherlands

    Cees J. J. Avezaat

  4. Addenbrooke’s Hospital, University of Cambridge, Cambridge, UK

    John D. Pickard , Marek Czosnyka  & Peter J. A. Hutchinson ,  & 

  5. School of Medicine, Nihon University, Tokyo, Japan

    Yoichi Katayama

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© 2005 Springer-Verlag

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Hutchinson, P.J. (2005). Microdialysis in traumatic brain injury — methodology and pathophysiology. In: Poon, W.S., et al. Intracranial Pressure and Brain Monitoring XII. Acta Neurochirurgica Supplementum, vol 95. Springer, Vienna. https://doi.org/10.1007/3-211-32318-X_91

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  • DOI: https://doi.org/10.1007/3-211-32318-X_91

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-24336-7

  • Online ISBN: 978-3-211-32318-2

  • eBook Packages: MedicineMedicine (R0)

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