Abstract
Nasopharyngeal carcinoma arises from the mucosa lining the nasopharynx. Although it is relatively uncommon worldwide, high incidence rates are observed in east and southeast Asia, North Africa, and the Middle East (Chang et al. 2021; Chen et al. 2019). Unlike other head and neck cancers, nasopharyngeal carcinoma tends to affect younger populations, peaking at approximately age 45–59 in high-risk populations (Chang et al. 2021). Radiation therapy remains the mainstay of treatment in these patients, resulting in excellent outcomes. Given the young ages of these patients at diagnosis and the high rates of tumor control, these patients are at risk for long-term toxicities from radiation therapy including xerostomia, swallowing dysfunction, endocrinopathies, cranial nerve deficits, hearing loss, and radiation necrosis. As such, it is imperative to consider how treatment outcomes can be improved in these patients. Delineation and coverage of microscopic disease within the clinical target volume (CTV) are crucial in head and neck radiation treatment planning. In this chapter, we discuss efforts to more accurately delineate target volumes in nasopharyngeal carcinoma.
References
Chang ET, Ye W, Zeng YX, Adami HO (2021) The evolving epidemiology of nasopharyngeal carcinoma. Cancer Epidemiol Biomarkers Prev 30:1035–1047
Chen YP, Chan ATC, Le QT, Blanchard P, Sun Y, Ma J (2019) Nasopharyngeal carcinoma. Lancet 394:64–80
Lee AW, Ng WT, Pan JJ et al (2018) International guideline for the delineation of the clinical target volumes (CTV) for nasopharyngeal carcinoma. Radiother Oncol 126:25–36
Lin L, Yao JJ, Zhou GQ (2016) The efficacy and toxicity of individualized intensity-modulated radiotherapy based on the tumor extension patterns of nasopharyngeal carcinoma. Oncotarget 7:20680–20690
RTOG Foundation (2023) NRG-alias protocol information. Available at: https://www.nrgoncology.org/Clinical-Trials/Protocol/nrg-hn001?filter=nrg-hn001
Sanford NN, Lau J, Lam MB et al (2019) Individualization of clinical target volume delineation based on stepwise spread of nasopharyngeal carcinoma: outcome of more than a decade of clinical experience. Int J Radiat Oncol Biol Phys 103(3):654–668
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Zhu, L.L., Chan, A.W. (2024). Individualized Clinical Target Volume Delineation in Nasopharyngeal Carcinoma. In: Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2023_473
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DOI: https://doi.org/10.1007/174_2023_473
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Publisher Name: Springer, Berlin, Heidelberg