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Renal Cell Carcinoma

  • Chapter
Stereotactic Body Radiation Therapy

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

Renal cell carcinoma (RCC) is traditionally considered to be a “radioresistant” malignancy. Surgery has been the mainstay of treatment in the management of primary RCC, from open to laparoscopic and more recently robotic radical nephrectomy. For selected patients, nephron-sparing partial nephrectomy is performed. Other local therapy options include radiofrequency ablation (RFA), cryoablation, and other ablative procedures. Adjuvant radiotherapy after nephrectomy in high-risk patients has been shown to improve local control but not overall survival. These patients have high propensity for developing distant metastases which may explain the lack of survival benefits with adjuvant radiotherapy. In addition, it is also very difficult to deliver high dose radiation with conventional technique because of the radiation tolerance of normal tissues, especially the small bowels. With the approved use of various effective targeted agents, patients with high risk and metastatic RCC are now surviving longer and the role of local therapy for both primary and metastatic RCC has also become more important. Stereotactic radiosurgery (SRS) has been shown to be very effective in the management of RCC brain metastases. Extracranially, conventional radiotherapy has played an important role in the palliation of metastatic RCC associated symptoms such as pain. Stereotactic body radiation therapy (SBRT), a continuum of technological advances in SRS from intracranial to extracranial application, has now evolved to show promise in the local management of primary RCC, local recurrence, and various metastatic sites.

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Authors and Affiliations

  1. Department of Radiation Oncology, The Methodist Hospital, Cancer Center and Research Institute, 6565 Fannin, DB1-077, Houston, TX, 77030, USA

    Bin S. Teh, Angel I. Blanco, Bo Xu & E. Brian Butler

  2. Department of Radiology and Radiation Oncology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan

    Hiromichi Ishiyama

  3. Center for Urologic Oncology and Minimally Invasive Therapies, Urology Institute, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA

    Lee E. Ponsky

  4. Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, 44106, USA

    Simon S. Lo & Rodney J. Ellis

  5. Department of Internal Medicine, Division of Oncology, University of Texas Health Sciences Center, Houston, TX, 77030, USA

    Robert J. Amato

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  1. Bin S. Teh
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  2. Hiromichi Ishiyama
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  3. Angel I. Blanco
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  4. Lee E. Ponsky
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  5. Simon S. Lo
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  6. Bo Xu
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  7. E. Brian Butler
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  8. Robert J. Amato
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  9. Rodney J. Ellis
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Correspondence to Bin S. Teh .

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Editors and Affiliations

  1. , Department of Radiation Oncology, Case Western Reserve University, Euclid Avenue 11100, Cleveland, 44106, Ohio, USA

    Simon S. Lo

  2. , Department of Radiation Oncology, Weil Cornell Medical College, Fannin, Ste#DB1-077 6565, Houston, 77030, Texas, USA

    Bin S. Teh

  3. Cancer Institute, Department of Radiation Oncology, National University Hospital, Lower Kent Ridge Road 5, Singapore, 119074, Singapore

    Jiade J. Lu

  4. , Department of Radiation Oncology, University of Colorado, Aurora, 80045, Colorado, USA

    Tracey E. Schefter

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© 2012 Springer-Verlag Berlin Heidelberg

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Teh, B.S. et al. (2012). Renal Cell Carcinoma. In: Lo, S., Teh, B., Lu, J., Schefter, T. (eds) Stereotactic Body Radiation Therapy. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2012_706

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  • DOI: https://doi.org/10.1007/174_2012_706

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-25604-2

  • Online ISBN: 978-3-642-25605-9

  • eBook Packages: MedicineMedicine (R0)

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