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Radiation-Induced Lung and Heart Toxicity

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Advances in Radiation Oncology in Lung Cancer

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

For many patients with lung cancer, thoracic radiation therapy (TRT) is an integral part of their treatment. The effect of TRT on normal structures is an important consideration when optimizing treatment plans for patients. This chapter will review radiation therapy (RT)-induced lung and heart injury including both the clinical and biological mechanisms for these toxicities. It will also analyze the variety of predictors of RT-induced lung and heart damage as well as methods to prevent and treat these toxicities.

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Acknowledgment

This work was supported by NIH Grant 2R201 CA69579-09.

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Authors and Affiliations

  1. Department of Radiation Oncology, University of North Carolina, Campus Box 7512, 101 Manning Drive, Chapel Hill, NC, 27514, USA

    Liyi Xie & Lawrence Marks

  2. Department of Radiation Oncology, Fudan University Shanghai Cancer Center, 200032, Shanghai, China

    Liyi Xie & Xiaoli Yu

  3. Radiation Oncology and Pathology, Department of Radiation Oncology, Duke University Medical Center, Box 3455, Durham, NC, 27710, USA

    Zeljko Vujaskovic

  4. Department of Radiation Oncology, Virginia Commonwealth University School of Medicine, 401 College Street, PO Box 980058, Richmond, VA, 23298-0058, USA

    Mitchell S. Anscher

  5. Landmark Medical Centre, 115 Cass Ave, Woonsocket, RI, 02895, USA

    Timothy D. Shafman

  6. 21st Century Oncology, Fort Myers, FL, USA

    Keith Miller

  7. Department of Radiation Oncology, University of Pennsylvania School of Medicine, 2 Donner Building, 3400 Spruce Street, Philadelphia, PA, 19104, USA

    Robert Prosnitz

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  1. Liyi Xie
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Correspondence to Lawrence Marks .

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  1. Institute of Lung Diseases, Institutski put 4, Sremska Kamenica, 21204, Serbia

    Branislav Jeremic

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Xie, L. et al. (2011). Radiation-Induced Lung and Heart Toxicity. In: Jeremic, B. (eds) Advances in Radiation Oncology in Lung Cancer. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2011_273

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