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The Skeleton and Musculature

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Fetal MRI

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

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Abstract

Based upon innovations in sequence technology, initial results demonstrate the ability of prenatal magnetic resonance imaging (MRI) to visualize the skeleton and muscles. Serving as an adjunct to ultrasonography (US), MRI may be useful in differentiating isolated from complex musculoskeletal abnormalities with potential impact on perinatal management.

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References

  • Applegate KE (2004) Can MR imaging be used to characterize fetal musculoskeletal development? Radiology 233:305–306

    Article  PubMed  Google Scholar 

  • Arlet V, Odent T, Aebi M (2003) Congenital scoliosis. Eur Spine J 12:456–463

    Article  PubMed  CAS  Google Scholar 

  • Bamberg C, Kalache KD (2004) Prenatal diagnosis of fetal growth restriction. Semin Fetal Neonatal Med 9:387–394

    Article  PubMed  Google Scholar 

  • Beals RK (2005) The distal arthrogryposes: a new classification of peripheral contractures. Clin Orthop Relat Res 435:203–210

    Article  PubMed  Google Scholar 

  • Brugger PC, Mittermayer C, Prayer D (2006) A new look at the fetus: thickslab T2-weighted sequences in fetal MRI. Eur J Radiol 57:182–186

    Article  PubMed  Google Scholar 

  • Brunelle F (2001) Fetal imaging in a new era. Ultrasound Obstet Gynecol 18:91–95

    Article  PubMed  CAS  Google Scholar 

  • Coakley FV, Glenn OA, Qayyum A, Barkovich AJ, Goldstein R, Filly RA (2004) Fetal MRI: a developing technique for the developing patient. AJR Am J Roentgenol 182:243–252

    Article  PubMed  Google Scholar 

  • Connolly SA, Jaramillo D, Hong JK, Shapiro F (2004) Skeletal development in fetal pig specimens: MR imaging of femur with histologic comparison. Radiology 233:505–514

    Article  PubMed  Google Scholar 

  • de Vries JI, Fong BF (2007) Changes in fetal motility as a result of congenital disorders: an overview. Ultrasound Obstet Gynecol 29:590–599

    Article  PubMed  Google Scholar 

  • Dugoff L, Thieme G, Hobbins JC (2000) Skeletal anomalies. Clin Perinatol 27:979–1005

    Article  PubMed  CAS  Google Scholar 

  • Garel C (2008a) Imaging the fetus: when does MRI really help? Pediatr Radiol 38(Suppl 3):S467–S470

    Article  PubMed  Google Scholar 

  • Garel C (2008b) Fetal MRI: what is the future? Ultrasound Obstet Gynecol 31:123–128

    Article  PubMed  CAS  Google Scholar 

  • Glenn OA, Barkovich AJ (2006a) Magnetic resonance imaging of the fetal brain and spine: an increasingly important tool in prenatal diagnosis, part 1. AJNR Am J Neuroradiol 27:1604–1611

    PubMed  CAS  Google Scholar 

  • Glenn OA, Barkovich J (2006b) Magnetic resonance imaging of the fetal brain and spine: an increasingly important tool in prenatal diagnosis: part 2. AJNR Am J Neuroradiol 27:1807–1814

    PubMed  CAS  Google Scholar 

  • Haak MC, van Vugt JM (2003) Pathophysiology of increased nuchal translucency: a review of the literature. Hum Reprod Update 9:175–184

    Article  PubMed  Google Scholar 

  • Keret D, Bronshtein M, Weintroub S (2005) Prenatal diagnosis of musculoskeletal anomalies. Clin Orthop Relat Res 434:8–15

    Article  PubMed  Google Scholar 

  • Kos M, Hafner T, Funduk-Kurjak B, Bozek T, Kurjak A (2002) Limb deformities and three-dimensional ultrasound. J Perinat Med 30:40–47

    Article  PubMed  Google Scholar 

  • Kubik-Huch RA, Wildermuth S, Cettuzzi L et al (2001) Fetus and uteroplacental unit: fast MR imaging with three-dimensional reconstruction and volumetry – feasibility study. Radiology 219:567–573

    PubMed  CAS  Google Scholar 

  • Levine D (2001) Three-dimensional fetal MR imaging: will it fulfill its promise? Radiology 219:313–315

    PubMed  CAS  Google Scholar 

  • Malinger G, Brugger PC, Prayer D (2006) Fetal MRI of the femur – preliminary results. Ultrasound Obstet Gynecol 27:593

    Google Scholar 

  • Mansfield P, Stehling MK, Ordidge RJ et al (1990) Echo planar imaging of the human fetus in utero at 0.5 T. Br J Radiol 63:833–841

    Article  PubMed  CAS  Google Scholar 

  • Morcuende JA, Weinstein SL (2003) Developmental skeletal anomalies. Birth Defects Res C Embryo Today 69:197–207

    Article  PubMed  CAS  Google Scholar 

  • Mortier GR (2001) The diagnosis of skeletal dysplasias: a multidisciplinary approach. Eur J Radiol 40:161–167

    Article  PubMed  CAS  Google Scholar 

  • Mulder EJ, Nikkels PG, Visser GH (2001) Fetal akinesia deformation sequence: behavioral development in a case of congenital myopathy. Ultrasound Obstet Gynecol 18:253–257

    Article  PubMed  CAS  Google Scholar 

  • Pagnotta G, Maffulli N, Aureli S, Maggi E, Mariani M, Yip KM (1996) Antenatal sonographic diagnosis of clubfoot: a six-year experience. Foot Ankle Surg 35:67–71

    Article  CAS  Google Scholar 

  • Paladini D, Greco E, Sglavo G, D‘Armiento MR, Penner I, Nappi C (2010) Congenital anomalies of upper extremities: prenatal ultrasound diagnosis, significance, and outcome. Am J Obstet Gynecol 202(596):e1–e10

    PubMed  Google Scholar 

  • Prayer D, Brugger PC (2007) Investigation of normal organ development with fetal MRI. Eur Radiol 17:2458–2471

    Article  PubMed  Google Scholar 

  • Pugash D, Brugger PC, Bettelheim D, Prayer D (2008) Prenatal ultrasound and fetal MRI: the comparative value of each modality in prenatal diagnosis. Eur J Radiol 68:214–226

    Article  PubMed  Google Scholar 

  • Robson CD, Barnewolt CE (2004) MR imaging of fetal head and neck anomalies. Neuroimaging Clin N Am 14:273–291

    Article  PubMed  Google Scholar 

  • Rossi A, Biancheri R, Cama A et al (2004) Imaging in spine and spinal cord malformations. Eur J Radiol 50:177–200

    Article  PubMed  Google Scholar 

  • Sekulic SR, Lukac DD, Naumovic NM (2005) The fetus cannot exercise like an stronaut: gravity loading is necessary for the physiological development during second half of pregnancy. Med Hypotheses 64:221–228

    Article  PubMed  Google Scholar 

  • Sentilhes L, Verspyck E, Patrier S, Eurin D, Lechevallier J, Marpeau L (2003) Amniotic band syndrome: pathogenesis, prenatal diagnosis and neonatal management. J Gynecol Obstet Biol Reprod (Paris) 32:693–704

    CAS  Google Scholar 

  • Sival DA, van Weerden TW, Vles JS, Timmer A, den Dunnen WF, Staal-Schreinemachers AL, Hoving EW, Sollie KM, Kranen-Mastenbroek VJ, Sauer PJ, Brouwer OF (2004) Neonatal loss of motor function in human spina bifida aperta. Pediatrics 114:427–434

    Article  PubMed  Google Scholar 

  • Smrcek JM, Germer U, Krokowski M, Berg C, Krapp M, Geipel A, Gembruch U (2003) Prenatal ultrasound diagnosis and management of body stalk anomaly: analysis of nine singleton and two multiple pregnancies. Ultrasound Obstet Gynecol 21:322–328

    Article  PubMed  CAS  Google Scholar 

  • Suri M (2005) Craniofacial syndromes. Semin Fetal Neonatal Med 10:243–257

    Article  PubMed  Google Scholar 

  • Trop I, Levine D (2001) Normal fetal anatomy as visualized with fast magnetic resonance imaging. Top Magn Reson Imaging 12:3–17

    Article  PubMed  CAS  Google Scholar 

  • von Kleist-Retzow JC, Cormier-Daire V, Viot G, Goldenberg A, Mardach B, Amiel J, Saada P, Dumez Y, Brunelle F, Saudubray JM, Chretien D, Rotig A, Rustin P, Munnich A, De Lonlay P (2003) Antenatal manifestations of mitochondrial respiratory chain deficiency. J Pediatr 143:208–212

    Article  Google Scholar 

  • Wax JR, Watson WJ, Miller RC, Ingardia CJ, Pinette MG, Cartin A, Grimes CK, Blackstone J (2008) Prenatal sonographic diagnosis of hemivertebrae: associations and outcomes. J Ultrasound Med 27:1023–1027

    PubMed  Google Scholar 

  • Witters I, Moerman P, Fryns JP (2002) Fetal akinesia deformation sequence: a study of 30 consecutive in utero diagnoses. Am J Med Genet 113:23–28

    Article  PubMed  Google Scholar 

  • Yfantis H, Nonaka D, Castellani R, Harman C, Sun CC (2002) Heterogeneity in fetal akinesia deformation sequence (FADS): autopsy confirmation in three 20–21-week fetuses. Prenat Diagn 22:42–47

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology/Division of Neuroradiology and Musculoskeletal Radiology, Medical University Vienna, Waehringer Guertel 18–20, A-1090, Vienna, Austria

    Stefan F. Nemec, Gregor Kasprian, Ursula Nemec & Daniela Prayer

  2. Center of Anatomy and Cell Biology, Integrative Morphology Group, Medical University Vienna, Waehringerstrasse 13, A-1090, Vienna, Austria

    Peter C. Brugger

  3. Medical Genetics Institute, Cedars Sinai Medical Center, 8700 Beverly Boulevard, PACT Suite 400, Los Angeles, CA, 90048, USA

    John M. Graham Jr.

Authors
  1. Stefan F. Nemec
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  2. Peter C. Brugger
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  3. Gregor Kasprian
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  4. Ursula Nemec
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  5. John M. Graham Jr.
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  6. Daniela Prayer
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Corresponding author

Correspondence to Stefan F. Nemec .

Editor information

Editors and Affiliations

  1. Klinik für Radiodiagnostik, Medizinische Universität Wien, Währinger Gürtel 18-20, Wien, 1090, Austria

    Daniela Prayer

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© 2010 Springer-Verlag Berlin Heidelberg

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Nemec, S.F., Brugger, P.C., Kasprian, G., Nemec, U., Graham, J.M., Prayer, D. (2010). The Skeleton and Musculature. In: Prayer, D. (eds) Fetal MRI. Medical Radiology(). Springer, Berlin, Heidelberg. https://doi.org/10.1007/174_2010_58

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  • DOI: https://doi.org/10.1007/174_2010_58

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-73270-9

  • Online ISBN: 978-3-540-73271-6

  • eBook Packages: MedicineMedicine (R0)

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