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Integration of Signaling Pathways Via Smad Proteins

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Smad Signal Transduction

Part of the book series: Proteins and Cell Regulation ((PROR,volume 5))

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Abstract

TGF-β ligands are involved in most aspects of embryonic development and post-natal homeostasis and numerous examples of crosstalk with other signaling pathways have been described. The Smad proteins are the most extensively characterized signal transducers downstream of the TGF-β superfamily of secreted growth factors. In most cases, Smad proteins have been shown to mediate this crosstalk via the formation of DNA-bound transcriptional complexes with transducers of other pathways, thereby modifying promoter selectivity and transcriptional output. We will examine the ability of Smads to integrate the signaling output of TGF-β ligands with other signaling pathways through direct interactions with other signal transducers

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Authors and Affiliations

  1. Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

    Etienne Labbé & Liliana Attisano

  2. Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada

    Liliana Attisano

Authors
  1. Etienne Labbé
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  2. Liliana Attisano
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  1. Leiden University Medical Center, Leiden, The Netherlands

    Peter ten Dijke

  2. Ludwig Institute for Cancer Research, Uppsala University, Sweden

    Carl-Henrik Heldin

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© 2006 Springer

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Labbé, E., Attisano, L. (2006). Integration of Signaling Pathways Via Smad Proteins. In: Dijke, P.t., Heldin, CH. (eds) Smad Signal Transduction. Proteins and Cell Regulation, vol 5. Springer, Dordrecht. https://doi.org/10.1007/1-4020-4709-6_15

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