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Scanning Probe Microscopy across Dimensions

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From Cells to Proteins: Imaging Nature across Dimensions

Part of the book series: NATO Security through Science Series ((NASTB))

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Abstract

Scanning probe microscopy offers interesting approaches to not only image but also manipulate samples in the micro- and nanoscale regime.

Atomic force microscopy became one of the most versatile microscopy methods in biology, since this type of microscopy works under ambient conditions and in many cases, no extensive sample preparation is necessary.

From imaging single living cells to large protein molecules and even more interestingly protein-protein interactions in real time, to micro- and nanoscale investigations of mechanical parameters such as viscoelasticity, atomic force microscopy has proved a useful technique.

Imaging biomolecules at atomic resolution is a dream which might come true within the next few years. A powerful new technique is magnetic resonance force microscopy, combining three-dimensional magnetic resonance imaging with the excellent force sensitivity of the atomic force microscope. This type of microscopy opens the possibility of performing scanning probe magnetic resonance imaging with a sensitivity more than 10 million times better than the sensitivity of the medical magnetic resonance imaging devices for visualizing of organs in the human body. This improved sensitivity extends magnetic resonance imaging into the nanometer realm.

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Author information

Authors and Affiliations

  1. Austrian Center of Competence for Tribology AC2T research GmbH, Viktor Kaplan-Straße 2, 2700, Wiener, Neustadt, Austria

    Ille C. Gebeshuber

  2. Institut für Allgemeine Physik, Technische Universität Wien, Wiedner Hauptstraße 8-10/E134, 1040, Vienna, Austria

    Ille C. Gebeshuber, Richard A. P. Smith, Hannspeter Winter & Friedrich Aumayr

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  1. Ille C. Gebeshuber
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  2. Richard A. P. Smith
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  3. Hannspeter Winter
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  4. Friedrich Aumayr
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Editor information

Editors and Affiliations

  1. CNR Institute of Biophysics, Pisa, Italy

    Valtere Evangelista , Laura Barsanti , Vincenzo Passarelli  & Paolo Gualtieri , ,  & 

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Gebeshuber, I.C., Smith, R.A.P., Winter, H., Aumayr, F. (2005). Scanning Probe Microscopy across Dimensions. In: Evangelista, V., Barsanti, L., Passarelli, V., Gualtieri, P. (eds) From Cells to Proteins: Imaging Nature across Dimensions. NATO Security through Science Series. Springer, Dordrecht . https://doi.org/10.1007/1-4020-3616-7_8

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