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Dynamic Nature of Tumour-Host Interactions Within the Tumor Microenvironment

  • Chapter
Integration/Interaction of Oncologic Growth

Part of the book series: Cancer Growth and Progression ((CAGP,volume 15))

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Abstract

The recent progress in tumor immunology exemplifies the successful application of modern biotechnology for the understanding of the complex natural or therapy-induced phenomenon of immune-mediated rejection of cancer. Tumor antigens recognized by T cells were identified and successfully utilized in active immunization trials for the induction of tumor-antigen specific T cells. This achievement has left, however, the clinicians and researchers perplexed by the paradoxical observation of the immunization-induced T cells can recognize tumor cells in standard assays but most often cannot induce tumor regression. In this presentation, we will argue that successful immunization is one of several steps required for tumor clearance but more work needs to be done to understand how T cells can localize and be effective at the receiving end within a tumor microenvironment in most cases not conducive to the execution of their effector function. In fact, metastatic melanoma stands out among human cancers because of its immune responsiveness. Yet, the reason(s) remain(s) unclear. We believe that the key to the understanding of this complex phenomenon relies on the real-time study of tumor/host interactions in the tumor microenvironment. Most likely, T cells induced by immunization can reach the tumor site but they are not capable of performing their effector function because they encounter a tumor microenvironment not conducive to T cell activation. In this chapter, we will review some of the basic approaches that may help solve this puzzle by studying directly human disease and its adaptation to treatment.

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Authors and Affiliations

  1. Department of Haematology, Oncology and Transfusion Medicine, Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany

    D. Nagorsen

  2. Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA

    F. M. Marincola

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  1. D. Nagorsen
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  1. Washington State University, Pullman, WA, USA

    Gary G. Meadows

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Nagorsen, D., Marincola, F.M. (2005). Dynamic Nature of Tumour-Host Interactions Within the Tumor Microenvironment. In: Meadows, G.G. (eds) Integration/Interaction of Oncologic Growth. Cancer Growth and Progression, vol 15. Springer, Dordrecht. https://doi.org/10.1007/1-4020-3414-8_10

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