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Radiofrequency Tumor Ablation in Children

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Tumor Ablation

Abstract

Percutaneous image-guided radiofrequency (RF) tumor ablation continues to gain momentum in adult patients as a viable and effective therapeutic option in the treatment of solid tumors in a variety of locations including the skeleton, liver, spleen, kidney, adrenal gland, and lung (1–6). In all these areas, the basic concept of RF tumor ablation is similar: localized and contained heat generation systematically induces focal coagulative necrosis and cell death. Cytotoxicity is best induced when regional temperatures reach and maintain 50° to 100°C. In children, RF tumor ablation has been used most widely in the treatment of osteoid osteoma. Percutaneous RF ablation (RFA) has fewer indications in the pediatric population, and hence, has been slower to evolve in the treatment of diseases of the liver, kidney, lung, and soft tissues.

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Author information

Authors and Affiliations

  1. Columbus Children’s Hospital, Ohio State University College of Medicine, Columbus, OH, USA

    William E. Shiels II DO (Associate Professor of Radiology and Chairman of Radiology)

  2. Harvard Medical School, Staff Radiologist, Children’s Hospital, Boston, MA, USA

    Stephen D. Brown MD (Instructor in Radiology)

Authors
  1. William E. Shiels II DO
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  2. Stephen D. Brown MD
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Editor information

Editors and Affiliations

  1. Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02115, USA

    Eric vanSonnenberg MD (Chief of Radiology, Interventional Radiologist) (Chief of Radiology, Interventional Radiologist)

  2. Brigham and Women’s Hospital Children’s Hospital, Boston, MA, 02115, USA

    Eric vanSonnenberg MD (Chief of Radiology, Interventional Radiologist) (Chief of Radiology, Interventional Radiologist)

  3. Boston, MA, 02115, USA

    William N. McMullen (Interventional Oncology Consultant) (Interventional Oncology Consultant)

  4. Department of Radiology, Ospedale Civile Busto Arsizio, 21052, Busto Arsizio, Italy

    Luigi Solbiati MD (Chairman) (Chairman)

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© 2005 Springer Science+Business Media, Inc.

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Shiels, W.E., Brown, S.D. (2005). Radiofrequency Tumor Ablation in Children. In: vanSonnenberg, E., McMullen, W.N., Solbiati, L., Livraghi, T., Müeller, P.R., Silverman, S.G. (eds) Tumor Ablation. Springer, New York, NY. https://doi.org/10.1007/0-387-28674-8_42

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  • DOI: https://doi.org/10.1007/0-387-28674-8_42

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-95539-1

  • Online ISBN: 978-0-387-28674-7

  • eBook Packages: MedicineMedicine (R0)

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